{"formatVersion":"1.1","id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/zuclopenthixol-uses-dosage-side-effects","path":"/library/zuclopenthixol-uses-dosage-side-effects","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/zuclopenthixol-uses-dosage-side-effects","title":"Zuclopenthixol","family":"Library detail","description":"Zuclopenthixol is an antipsychotic drug used to treat positive symptoms of schizophrenia. Learn more about how it is used, interactions, and more.","language":"en-US","access":{"audience":"custom-shared-preview","indexable":true},"provenance":{"sourceUrl":"https://www.mentalhealth.com/library/zuclopenthixol-uses-dosage-side-effects","wordpressId":"254","contentCompleteness":"complete","dateScope":"original-source"},"authors":[{"@type":"Person","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/jenni-jacobsen#person","name":"Jenni Jacobsen, Ph.D.","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/jenni-jacobsen"}],"reviewer":{"@type":"Person","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/brittany-ferri#person","name":"Brittany Ferri, Ph.D.","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/brittany-ferri"},"dates":{"datePublished":"2022-11-22T19:00:00Z","dateModified":"2025-08-13T12:03:03Z","lastReviewed":"2022-11-23"},"content":{"html":"<nav class=\"breadcrumbs\" aria-label=\"Breadcrumb\"><ol><li><a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/\">Home</a></li><li><a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/library\">Library</a></li><li><a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/medications\">Medications</a></li><li><span aria-current=\"page\">Zuclopenthixol</span></li></ol></nav><div class=\"article-page article-standard\" data-library-standard><div class=\"article-main-grid\"><header class=\"article-heading\"><h1>Zuclopenthixol</h1><p class=\"article-inline-credits\"><span>Written by <a class=\"article-credit-person\" href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/jenni-jacobsen\"><img src=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/wordpress/97.jpg\" alt=\"\" width=\"22\" height=\"22\" loading=\"lazy\">Jenni Jacobsen, Ph.D.</a></span><span>Medically reviewed by <a class=\"article-credit-person\" href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/brittany-ferri\"><img src=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/wordpress/9737.jpeg\" alt=\"\" width=\"22\" height=\"22\" loading=\"lazy\">Brittany Ferri, Ph.D.</a></span></p><div class=\"article-dates\"><span>Published on <time datetime=\"2022-11-22T19:00:00Z\">November 22, 2022</time></span><span aria-hidden=\"true\"> · </span><span>Updated on <time datetime=\"2025-08-13T12:03:03Z\">August 13, 2025</time></span></div></header><div class=\"article-jumpbar\"></div><div class=\"article-layout\"><div class=\"article-reading\"><article class=\"prose\" id=\"article-content\"><div class=\"article-intro\" data-source-field=\"hero\"><p>Zuclopenthixol is an antipsychotic drug used to treat schizophrenia. It is important to take this medication exactly as prescribed, and report any side effects to your doctor, as some side effects can be serious</p></div><figure class=\"article-feature\"><img src=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/library/editorial-17226.webp\" alt=\"A woman reads a medicine label beside her phone at home.\" width=\"1200\" height=\"586\" loading=\"eager\" decoding=\"async\"></figure><section class=\"article-takeaways\" aria-labelledby=\"key-takeaways\"><h2 id=\"key-takeaways\">Key takeaways</h2><ul><li>Zuclopenthixol is an antipsychotic used for schizophrenia and some other psychotic symptoms.</li><li>Zuclopenthixol reduces dopamine activity and is available in oral and injectable formulations.</li><li>Side effects and interactions with other medicines require individualized prescribing and ongoing monitoring.</li></ul></section><h2 id=\"zuclopenthixol-brand-names\">Zuclopenthixol brand names</h2><p>Zuclopenthixol is not approved by the FDA for sale in the United States. It is available internationally under the following brand names:</p><ul><li>Clopixol</li><li>Clopixol Acuphase</li><li>Clopixol Concentrate</li><li>Cisordinol</li></ul><h2 id=\"what-is-zuclopenthixol-prescribed-for\">What is zuclopenthixol prescribed for?</h2><p>As an antipsychotic medication, zuclopenthixol is most commonly prescribed in the treatment of <a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/schizophrenia\" class=\"article-inline-link\">schizophrenia</a>. It may also be used to treat symptoms of psychosis that occur during episodes of mania in <a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/bipolar-disorder\" class=\"article-inline-link\">bipolar disorder</a>. Zuclopenthixol is sometimes used to treat patients in psychiatric crises, but doctors use caution when prescribing zuclopenthixol for this purpose, as there is a lack of research assessing the safety and effectiveness of zuclopenthixol in psychiatric emergencies <sup><a href=\"#pubchem-compound-summary-cid-5311507-zuclopenthixol\" aria-label=\"Reference 1\" class=\"article-inline-link article-citation\">[1]</a></sup>.</p><h2 id=\"how-does-zuclopenthixol-work\">How does zuclopenthixol work?</h2><p>Zuclopenthixol works by blocking the activity of a brain chemical called dopamine, which is believed to be elevated in patients with schizophrenia. By reducing dopamine activity, zuclopenthixol and other antipsychotics are able to alleviate symptoms of psychosis <sup><a href=\"#pubchem-compound-summary-cid-5311507-zuclopenthixol\" aria-label=\"Reference 1\" class=\"article-inline-link article-citation\">[1]</a></sup>.</p><h2 id=\"how-is-zuclopenthixol-usually-taken\">How is zuclopenthixol usually taken?</h2><p>Zuclopenthixol is available as both an oral tablet and a depot injection. An injection of zuclopenthixol produces effects that last for two to three days <sup><a href=\"#zuclopenthixol-acetate-acute-schizophrenia-similar-serious-mental-illnesses\" aria-label=\"Reference 2\" class=\"article-inline-link article-citation\">[2]</a></sup>. The oral form of zuclopenthixol is available as a tablet that comes in various dosages. A doctor will determine the best dose for an individual patient. The lowest oral dose that produces effective results should be used.</p><h2 id=\"how-long-does-zuclopenthixol-stay-in-your-system\">How long does zuclopenthixol stay in your system?</h2><p>Zuclopenthixol has a relatively long half-life, of about 20 hours on average. This means that half of the initial concentration of the drug is cleared from the body within 20 hours <sup><a href=\"#pubchem-compound-summary-cid-5311507-zuclopenthixol\" aria-label=\"Reference 1\" class=\"article-inline-link article-citation\">[1]</a></sup>. Given that a drug is eliminated from the body within 4 to 5 half lives, you can expect zuclopenthixol to remain in the body for around 4 to 5 days.</p><h2 id=\"zuclopenthixol-side-effects\">Zuclopenthixol side effects</h2><p>Just like any prescription medication, there are potential side effects with zuclopenthixol. Some common side effects of this medication include <sup><a href=\"#zuclopenthixol-dihydrochloride-schizophrenia\" class=\"article-inline-link article-citation\" aria-label=\"Reference 3\">[3]</a></sup>:</p><ul><li>Drowsiness</li><li>Dizziness</li><li>Headache</li><li>Confusion</li><li>Tremor</li><li>Dry mouth</li><li>Blurred vision</li><li>Lightheadedness</li><li>Excessive salivation</li><li>Slowed movement</li><li>Involuntary muscle movements</li><li>Chills</li><li>Agitation or restlessness </li></ul><p>The side effects above are generally mild and will get better with time. If you experience any adverse reactions that are severe or do not improve, talk with your doctor. They may switch you to another medication with fewer adverse effects or adjust your dosage.</p><h2 id=\"zuclopenthixol-precautions\">Zuclopenthixol precautions</h2><p>It is important to work closely with your doctor while taking zuclopenthixol. The medication should be taken exactly as prescribed, and you should closely monitor side effects. <sup><a href=\"#pubchem-compound-summary-cid-5311507-zuclopenthixol\" aria-label=\"Reference 1\" class=\"article-inline-link article-citation\">[1]</a></sup>.</p><p>Another precaution to consider with this medication is that it has not been as well-researched as other antipsychotic medications, especially for the treatment of psychiatric emergencies <sup><a href=\"#pubchem-compound-summary-cid-5311507-zuclopenthixol\" aria-label=\"Reference 1\" class=\"article-inline-link article-citation\">[1]</a></sup>.</p><p>Some medical conditions may make it unsafe to take zuclopenthixol. These conditions include <sup><a href=\"#clopixol-200-mg-ml-solution-injection\" aria-label=\"Reference 4\" class=\"article-inline-link article-citation\">[4]</a></sup>:</p><ul><li>Liver or heart disease</li><li>Respiratory problems</li><li>Kidney failure</li><li>Epilepsy</li><li>Parkinson’s disease</li><li>Prostatic hypertrophy</li><li>Thyroid conditions </li></ul><p>Talk with your doctor if you have any of the above health conditions. Your dose may need to be altered, or you may need to be closely monitored for side effects. In some cases, your doctor will choose an alternative medication to zuclopenthixol if an existing medical condition makes it dangerous for you to take the drug.</p><p>You should avoid the use of alcohol while taking zuclopenthixol, as it can cause dangerous interaction effects with alcohol. Be sure to tell your doctor about any medications you are taking before beginning zuclopenthixol, as some medications can interact with it as well, making it less or overly effective <sup><a href=\"#pubchem-compound-summary-cid-5311507-zuclopenthixol\" aria-label=\"Reference 1\" class=\"article-inline-link article-citation\">[1]</a></sup>.</p><h2 id=\"zuclopenthixol-interactions\">Zuclopenthixol interactions</h2><p>Numerous medications can cause interaction effects when taken alongside zuclopenthixol. While the following list is not exhaustive, it contains some of the most common medications that are known to interact with zuclopenthixol <sup><a href=\"#clopixol-200-mg-ml-solution-injection\" aria-label=\"Reference 4\" class=\"article-inline-link article-citation\">[4]</a></sup>: </p><ul><li>Barbiturates</li><li>Any central nervous system depressant</li><li>General anesthetics</li><li>Atropine</li><li>Neuromuscular blocking agents</li><li>Antiparkinson drugs</li><li>Quinidine</li><li>Digoxin</li><li>Corticosteroids</li><li>Lithium</li><li>Sibutramine</li><li>Metoclopramide</li><li>Piperazine</li><li>Hydralazine</li><li>Doxazosin</li><li>Tricyclic antidepressants</li><li>Antipsychotics - Thioridazine</li><li>Antihistamines</li><li>Moxifloxacin</li><li>Antihypertensives - Guanethidine</li><li>Cisapride</li><li>Sotalol</li><li>Amiodarone</li><li>Dofetilide</li><li>Erythromycin</li></ul><p>Since the list above is not exhaustive, it’s critical to inform your doctor of all medications you are taking, so that they can determine if a potential interaction effect exists.</p><h2 id=\"what-to-do-if-you-overdose-on-zuclopenthixol\">What to do if you overdose on zuclopenthixol</h2><p>Zuclopenthixol should be taken exactly as prescribed by a doctor to reduce the risk of overdose. It’s also important to communicate with your doctor about other medications you are taking, as some medications can increase overdose risk when taken in combination with zuclopenthixol. </p><p>Some signs of a zuclopenthixol overdose include <sup><a href=\"#pubchem-compound-summary-cid-5311507-zuclopenthixol\" aria-label=\"Reference 1\" class=\"article-inline-link article-citation\">[1]</a></sup>:</p><ul><li>Convulsions</li><li>Dangerously low blood pressure</li><li>Extreme drowsiness</li><li>Shock</li><li>Either hyper or hypothermia</li><li>Extrapyramidal symptoms (tremor, muscle stiffness, involuntary muscle contraction)</li><li>Coma </li></ul><p>If you or someone you know has taken zuclopenthixol and are demonstrating overdose symptoms, seek immediate medical attention. It is critical to call 911 if a person has collapsed or is non-responsive after taking zuclopenthixol.</p><h2 id=\"faq\">FAQ</h2><h3 id=\"what-are-the-alternatives-to-zuclopenthixol\">What are the alternatives to zuclopenthixol?</h3><p>Zuclopenthixol is not FDA-approved for use in the United States, which means that an alternative medication will need to be chosen for patients seeking treatment of psychosis or schizophrenia. Zuclopenthixol is a typical or first generation antipsychotic drug. Other medications in this class include <a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/trifluoperazine-uses-dosage-side-effects\" class=\"article-inline-link\">trifluoperazine</a>, <a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/perphenazine-use-dosage-interactions-effects\" class=\"article-inline-link\">perphenazine</a>, prochlorperazine, acetophenazine, triflupromazine, <a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/antipsychotics\" class=\"article-inline-link\">mesoridazine</a>, <a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/haloperidol-uses-dosage-side-effects\" class=\"article-inline-link\">haloperidol</a>, <a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/antipsychotics\" class=\"article-inline-link\">thiothixene</a>, chlorprothixene, <a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/loxapine-uses-dosage-side-effects\" class=\"article-inline-link\">loxapine</a>, <a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/molindone-uses-side-effects-interactions\" class=\"article-inline-link\">molindone</a>, and <a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/antipsychotics\" class=\"article-inline-link\">pimozide</a> <sup><a href=\"#antipsychotic-medications\" aria-label=\"Reference 5\" class=\"article-inline-link article-citation\">[5]</a></sup>.</p></article><div class=\"article-endmatter\"><section class=\"article-sources\" id=\"references\" data-source-references=\"\" data-reference-list=\"\" data-reference-style=\"author-date-numbered\"><h2 id=\"references-2\">References</h2><ol>\n    <li id=\"pubchem-compound-summary-cid-5311507-zuclopenthixol\" data-reference-number=\"1\">National Center for Biotechnology Information. (2022). PubChem compound summary for CID 5311507, zuclopenthixol. Retrieved November 12, 2022 from <a href=\"https://pubchem.ncbi.nlm.nih.gov/compound/Zuclopenthixol\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">National Library of Medicine</a>.</li>\n    <li id=\"zuclopenthixol-acetate-acute-schizophrenia-similar-serious-mental-illnesses\" data-reference-number=\"2\">Jayakody, K., Gibson, R.C., Kumar, A., &amp; Gunadasa, S. (2012). Zuclopenthixol acetate for acute schizophrenia and similar serious mental illnesses. Cochrane Database of Systematic Reviews, 4. <a href=\"https://doi.org/10.1002/14651858.CD000525.pub3\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">Zuclopenthixol acetate for acute schizophrenia and similar serious mental illnesses</a></li>\n    <li id=\"zuclopenthixol-dihydrochloride-schizophrenia\" data-reference-number=\"3\">Bryan, E.J., Purcell, M.A., &amp; Kumar, A. (2017). Zuclopenthixol dihydrochloride for schizophrenia. Cochrane Database of Systematic Reviews, 11. doi: 10.1002/14651858.CD005474.pub2</li>\n    <li id=\"clopixol-200-mg-ml-solution-injection\" data-reference-number=\"4\">(2022). Clopixol 200 mg/ml solution for injection. Retrieved November 12, 2022 from <a href=\"https://www.medicines.org.uk/emc/product/6414/smpc#gref\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">Electronic Medicines Compendium</a></li>\n    <li id=\"antipsychotic-medications\" data-reference-number=\"5\">Chokhawala, K., &amp; Stevens, L. (2022). Antipsychotic medications. National Library of Medicine. Accessed November 12, 2022 from <a href=\"https://www.ncbi.nlm.nih.gov/books/NBK519503/#:~:text=The%20first%2Dgeneration%20antipsychotics%20work,cholinergic%2C%20and%20histaminergic%20blocking%20action\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">National Library of Medicine</a></li>\n</ol></section><section class=\"article-medical article-panel\"><h2 id=\"medical-content\">Medical Content</h2><p><a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/clinical-affairs\">The Clinical Affairs Team</a> at MentalHealth.com is a dedicated group of medical professionals with diverse and extensive clinical experience. They actively contribute to the development of content, products, and services, and meticulously review all medical material before publication to ensure accuracy and alignment with current research and conversations in mental health. For more information, please visit the <a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/publishing/editorial-policy\">Editorial Policy</a>.</p></section><section class=\"article-about article-panel\"><h2 id=\"about-mentalhealth-com\">About MentalHealth.com</h2><p>MentalHealth.com helps people understand themselves, build healthier relationships, and access the right care. We bring together mental health education, diagnostics, and care management to support well-being throughout every phase of life.</p><div class=\"article-contributors\"><section class=\"article-bio\"><img src=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/wordpress/97.jpg\" alt=\"\" width=\"64\" height=\"64\" loading=\"lazy\"><div><p class=\"article-bio-role\">Author</p><h3 id=\"jenni-jacobsen-ph-d\"><a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/jenni-jacobsen\">Jenni Jacobsen, Ph.D.</a></h3><p class=\"article-bio-credentials\">Ph.D., LSW, MSW</p><p>Jenni Jacobsen, Ph.D. is a licensed social worker, behavioral health consultant and medical reviewer. She holds a Ph.D. in clinical psychology.</p><dl><div><dt>Published</dt><dd><time datetime=\"2022-11-22T19:00:00Z\">November 22, 2022</time></dd></div><div><dt>Updated</dt><dd><time datetime=\"2025-08-13T12:03:03Z\">August 13, 2025</time></dd></div></dl></div></section><section class=\"article-bio\"><img src=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/wordpress/9737.jpeg\" alt=\"\" width=\"64\" height=\"64\" loading=\"lazy\"><div><p class=\"article-bio-role\">Medical Reviewer</p><h3 id=\"brittany-ferri-ph-d\"><a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/brittany-ferri\">Brittany Ferri, Ph.D.</a></h3><p class=\"article-bio-credentials\">OTR/L</p><p>Brittany Ferri, Ph.D., is a medical reviewer and subject matter expert in behavioral health, pediatrics, and telehealth.</p><dl><div><dt>Reviewed</dt><dd><time datetime=\"2022-11-23\">November 23, 2022</time></dd></div></dl></div></section></div></section><section class=\"article-expert article-expert-mobile\" aria-label=\"Subject matter expert\" data-expert-kind=\"related\"><p class=\"article-bio-role\">Subject matter expert</p><div class=\"article-expert-identity\"><img src=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/wordpress/3060.webp\" alt=\"\" width=\"64\" height=\"64\" loading=\"lazy\"><h2><a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/leila-khurshid\">Leila Khurshid, Pharm.D.</a></h2></div><p class=\"article-expert-focus\">Clinical pharmacy and medication</p><a class=\"profile-experience-link experience-button\" href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/leila-khurshid\">View experience</a></section><section class=\"article-topic-community article-topic-community-mobile\" aria-label=\"Related communities\"><img class=\"topic-community-banner\" src=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/library/editorial-17234.webp\" alt=\"\" width=\"48\" height=\"48\" loading=\"lazy\"><p class=\"topic-community-label\">Related communities</p><h2>Medications</h2><p>Explore questions and perspectives about psychiatric medications and the treatment experience.</p><a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/community/medications\">Explore community</a></section></div></div><aside class=\"article-sidebar\" tabindex=\"0\" data-bounded-rail=\"\" aria-label=\"Article navigation and related information\"><details class=\"article-contents\" open data-section-preview=\"3\" data-expanded=\"false\" data-scrolled-past=\"false\"><summary><strong>Table of contents</strong><span aria-hidden=\"true\"></span><small data-current-section=\"\">Choose a section</small></summary><nav aria-label=\"Article contents\"><ol id=\"article-section-list\"><li><a href=\"#zuclopenthixol-brand-names\" title=\"Zuclopenthixol brand names\" aria-label=\"Zuclopenthixol brand names\">Zuclopenthixol brand names</a></li><li><a href=\"#what-is-zuclopenthixol-prescribed-for\" title=\"What is zuclopenthixol prescribed for?\" aria-label=\"What is zuclopenthixol prescribed for?\">What is zuclopenthixol prescribed for?</a></li><li><a href=\"#how-does-zuclopenthixol-work\" title=\"How does zuclopenthixol work?\" aria-label=\"How does zuclopenthixol work?\">How does zuclopenthixol work?</a></li><li><a href=\"#how-is-zuclopenthixol-usually-taken\" title=\"How is zuclopenthixol usually taken?\" aria-label=\"How is zuclopenthixol usually taken?\">How is zuclopenthixol usually taken?</a></li><li><a href=\"#how-long-does-zuclopenthixol-stay-in-your-system\" title=\"How long does zuclopenthixol stay in your system?\" aria-label=\"How long does zuclopenthixol stay in your system?\">How long does zuclopenthixol stay in your system?</a></li><li><a href=\"#zuclopenthixol-side-effects\" title=\"Zuclopenthixol side effects\" aria-label=\"Zuclopenthixol side effects\">Zuclopenthixol side effects</a></li><li><a href=\"#zuclopenthixol-precautions\" title=\"Zuclopenthixol precautions\" aria-label=\"Zuclopenthixol precautions\">Zuclopenthixol precautions</a></li><li><a href=\"#zuclopenthixol-interactions\" title=\"Zuclopenthixol interactions\" aria-label=\"Zuclopenthixol interactions\">Zuclopenthixol interactions</a></li><li><a href=\"#what-to-do-if-you-overdose-on-zuclopenthixol\" title=\"What to do if you overdose on zuclopenthixol\" aria-label=\"What to do if you overdose on zuclopenthixol\">What to do if you overdose on zuclopenthixol</a></li><li><a href=\"#faq\" title=\"FAQ\" aria-label=\"FAQ\">FAQ</a></li></ol><button type=\"button\" class=\"article-sections-toggle\" data-sections-toggle aria-controls=\"article-section-list\" aria-expanded=\"false\">View more</button></nav></details><section class=\"article-expert\" aria-label=\"Subject matter expert\" data-expert-kind=\"related\"><p class=\"article-bio-role\">Subject matter expert</p><div class=\"article-expert-identity\"><img src=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/wordpress/3060.webp\" alt=\"\" width=\"64\" height=\"64\" loading=\"lazy\"><h2><a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/leila-khurshid\">Leila Khurshid, Pharm.D.</a></h2></div><p class=\"article-expert-focus\">Clinical pharmacy and medication</p><a class=\"profile-experience-link experience-button\" href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/leila-khurshid\">View experience</a></section><section class=\"article-topic-community\" aria-label=\"Related communities\"><img class=\"topic-community-banner\" src=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/library/editorial-17234.webp\" alt=\"\" width=\"48\" height=\"48\" loading=\"lazy\"><p class=\"topic-community-label\">Related communities</p><h2>Medications</h2><p>Explore questions and perspectives about psychiatric medications and the treatment experience.</p><a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/community/medications\">Explore community</a></section></aside></div></div></div>","text":"HomeLibraryMedicationsZuclopenthixolZuclopenthixolWritten by Jenni Jacobsen, Ph.D.Medically reviewed by Brittany Ferri, Ph.D.Published on November 22, 2022 · Updated on August 13, 2025Zuclopenthixol is an antipsychotic drug used to treat schizophrenia. It is important to take this medication exactly as prescribed, and report any side effects to your doctor, as some side effects can be seriousKey takeawaysZuclopenthixol is an antipsychotic used for schizophrenia and some other psychotic symptoms.Zuclopenthixol reduces dopamine activity and is available in oral and injectable formulations.Side effects and interactions with other medicines require individualized prescribing and ongoing monitoring.Zuclopenthixol brand namesZuclopenthixol is not approved by the FDA for sale in the United States. It is available internationally under the following brand names:ClopixolClopixol AcuphaseClopixol ConcentrateCisordinolWhat is zuclopenthixol prescribed for?As an antipsychotic medication, zuclopenthixol is most commonly prescribed in the treatment of schizophrenia. It may also be used to treat symptoms of psychosis that occur during episodes of mania in bipolar disorder. Zuclopenthixol is sometimes used to treat patients in psychiatric crises, but doctors use caution when prescribing zuclopenthixol for this purpose, as there is a lack of research assessing the safety and effectiveness of zuclopenthixol in psychiatric emergencies [1].How does zuclopenthixol work?Zuclopenthixol works by blocking the activity of a brain chemical called dopamine, which is believed to be elevated in patients with schizophrenia. By reducing dopamine activity, zuclopenthixol and other antipsychotics are able to alleviate symptoms of psychosis [1].How is zuclopenthixol usually taken?Zuclopenthixol is available as both an oral tablet and a depot injection. An injection of zuclopenthixol produces effects that last for two to three days [2]. The oral form of zuclopenthixol is available as a tablet that comes in various dosages. A doctor will determine the best dose for an individual patient. The lowest oral dose that produces effective results should be used.How long does zuclopenthixol stay in your system?Zuclopenthixol has a relatively long half-life, of about 20 hours on average. This means that half of the initial concentration of the drug is cleared from the body within 20 hours [1]. Given that a drug is eliminated from the body within 4 to 5 half lives, you can expect zuclopenthixol to remain in the body for around 4 to 5 days.Zuclopenthixol side effectsJust like any prescription medication, there are potential side effects with zuclopenthixol. Some common side effects of this medication include [3]:DrowsinessDizzinessHeadacheConfusionTremorDry mouthBlurred visionLightheadednessExcessive salivationSlowed movementInvoluntary muscle movementsChillsAgitation or restlessness The side effects above are generally mild and will get better with time. If you experience any adverse reactions that are severe or do not improve, talk with your doctor. They may switch you to another medication with fewer adverse effects or adjust your dosage.Zuclopenthixol precautionsIt is important to work closely with your doctor while taking zuclopenthixol. The medication should be taken exactly as prescribed, and you should closely monitor side effects. [1].Another precaution to consider with this medication is that it has not been as well-researched as other antipsychotic medications, especially for the treatment of psychiatric emergencies [1].Some medical conditions may make it unsafe to take zuclopenthixol. These conditions include [4]:Liver or heart diseaseRespiratory problemsKidney failureEpilepsyParkinson’s diseaseProstatic hypertrophyThyroid conditions Talk with your doctor if you have any of the above health conditions. Your dose may need to be altered, or you may need to be closely monitored for side effects. In some cases, your doctor will choose an alternative medication to zuclopenthixol if an existing medical condition makes it dangerous for you to take the drug.You should avoid the use of alcohol while taking zuclopenthixol, as it can cause dangerous interaction effects with alcohol. Be sure to tell your doctor about any medications you are taking before beginning zuclopenthixol, as some medications can interact with it as well, making it less or overly effective [1].Zuclopenthixol interactionsNumerous medications can cause interaction effects when taken alongside zuclopenthixol. While the following list is not exhaustive, it contains some of the most common medications that are known to interact with zuclopenthixol [4]: BarbituratesAny central nervous system depressantGeneral anestheticsAtropineNeuromuscular blocking agentsAntiparkinson drugsQuinidineDigoxinCorticosteroidsLithiumSibutramineMetoclopramidePiperazineHydralazineDoxazosinTricyclic antidepressantsAntipsychotics - ThioridazineAntihistaminesMoxifloxacinAntihypertensives - GuanethidineCisaprideSotalolAmiodaroneDofetilideErythromycinSince the list above is not exhaustive, it’s critical to inform your doctor of all medications you are taking, so that they can determine if a potential interaction effect exists.What to do if you overdose on zuclopenthixolZuclopenthixol should be taken exactly as prescribed by a doctor to reduce the risk of overdose. It’s also important to communicate with your doctor about other medications you are taking, as some medications can increase overdose risk when taken in combination with zuclopenthixol. Some signs of a zuclopenthixol overdose include [1]:ConvulsionsDangerously low blood pressureExtreme drowsinessShockEither hyper or hypothermiaExtrapyramidal symptoms (tremor, muscle stiffness, involuntary muscle contraction)Coma If you or someone you know has taken zuclopenthixol and are demonstrating overdose symptoms, seek immediate medical attention. It is critical to call 911 if a person has collapsed or is non-responsive after taking zuclopenthixol.FAQWhat are the alternatives to zuclopenthixol?Zuclopenthixol is not FDA-approved for use in the United States, which means that an alternative medication will need to be chosen for patients seeking treatment of psychosis or schizophrenia. Zuclopenthixol is a typical or first generation antipsychotic drug. Other medications in this class include trifluoperazine, perphenazine, prochlorperazine, acetophenazine, triflupromazine, mesoridazine, haloperidol, thiothixene, chlorprothixene, loxapine, molindone, and pimozide [5].References National Center for Biotechnology Information. (2022). PubChem compound summary for CID 5311507, zuclopenthixol. Retrieved November 12, 2022 from National Library of Medicine. Jayakody, K., Gibson, R.C., Kumar, A., & Gunadasa, S. (2012). Zuclopenthixol acetate for acute schizophrenia and similar serious mental illnesses. Cochrane Database of Systematic Reviews, 4. Zuclopenthixol acetate for acute schizophrenia and similar serious mental illnesses Bryan, E.J., Purcell, M.A., & Kumar, A. (2017). Zuclopenthixol dihydrochloride for schizophrenia. Cochrane Database of Systematic Reviews, 11. doi: 10.1002/14651858.CD005474.pub2 (2022). Clopixol 200 mg/ml solution for injection. Retrieved November 12, 2022 from Electronic Medicines Compendium Chokhawala, K., & Stevens, L. (2022). Antipsychotic medications. National Library of Medicine. Accessed November 12, 2022 from National Library of Medicine Medical ContentThe Clinical Affairs Team at MentalHealth.com is a dedicated group of medical professionals with diverse and extensive clinical experience. They actively contribute to the development of content, products, and services, and meticulously review all medical material before publication to ensure accuracy and alignment with current research and conversations in mental health. For more information, please visit the Editorial Policy.About MentalHealth.comMentalHealth.com helps people understand themselves, build healthier relationships, and access the right care. We bring together mental health education, diagnostics, and care management to support well-being throughout every phase of life.AuthorJenni Jacobsen, Ph.D.Ph.D., LSW, MSWJenni Jacobsen, Ph.D. is a licensed social worker, behavioral health consultant and medical reviewer. She holds a Ph.D. in clinical psychology.PublishedNovember 22, 2022UpdatedAugust 13, 2025Medical ReviewerBrittany Ferri, Ph.D.OTR/LBrittany Ferri, Ph.D., is a medical reviewer and subject matter expert in behavioral health, pediatrics, and telehealth.ReviewedNovember 23, 2022Subject matter expertLeila Khurshid, Pharm.D.Clinical pharmacy and medicationView experienceRelated communitiesMedicationsExplore questions and perspectives about psychiatric medications and the treatment experience.Explore communityTable of contentsChoose a sectionZuclopenthixol brand namesWhat is zuclopenthixol prescribed for?How does zuclopenthixol work?How is zuclopenthixol usually taken?How long does zuclopenthixol stay in your system?Zuclopenthixol side effectsZuclopenthixol precautionsZuclopenthixol interactionsWhat to do if you overdose on zuclopenthixolFAQView moreSubject matter expertLeila Khurshid, Pharm.D.Clinical pharmacy and medicationView experienceRelated communitiesMedicationsExplore questions and perspectives about psychiatric medications and the treatment experience.Explore community","wordCount":1191},"schema":{"@context":"https://schema.org","@graph":[{"@type":"Organization","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/#organization","name":"MentalHealth.com","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/"},{"@type":"WebSite","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/#website","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/","name":"MentalHealth.com","inLanguage":"en-US","publisher":{"@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/#organization"}},{"@type":"BreadcrumbList","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/zuclopenthixol-uses-dosage-side-effects#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://mentalhealth-v2.workspace-454808.chatgpt.site/"},{"@type":"ListItem","position":2,"name":"Library","item":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library"},{"@type":"ListItem","position":3,"name":"Medications","item":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/medications"},{"@type":"ListItem","position":4,"name":"Zuclopenthixol","item":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/zuclopenthixol-uses-dosage-side-effects"}]},{"@type":"ImageObject","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/zuclopenthixol-uses-dosage-side-effects#primaryimage","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/library/editorial-17226.webp","contentUrl":"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/library/editorial-17226.webp","width":1200,"height":586,"encodingFormat":"image/webp","caption":"A woman reads a medicine label beside her phone at home."},{"@type":"Person","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/jenni-jacobsen#person","name":"Jenni Jacobsen, Ph.D.","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/jenni-jacobsen","jobTitle":"Ph.D., LSW, MSW","image":"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/wordpress/97.jpg"},{"@type":"Person","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/brittany-ferri#person","name":"Brittany Ferri, Ph.D.","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/brittany-ferri","jobTitle":"OTR/L","image":"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/wordpress/9737.jpeg","sameAs":["https://www.linkedin.com/in/brittanyferri/"]},{"@type":"Article","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/zuclopenthixol-uses-dosage-side-effects#article","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/zuclopenthixol-uses-dosage-side-effects","headline":"Zuclopenthixol","description":"Zuclopenthixol is an antipsychotic drug used to treat positive symptoms of schizophrenia. 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(2022). PubChem compound summary for CID 5311507, zuclopenthixol. Retrieved November 12, 2022 from National Library of Medicine.","links":[{"url":"https://pubchem.ncbi.nlm.nih.gov/compound/Zuclopenthixol","label":"National Library of Medicine"}],"url":"https://pubchem.ncbi.nlm.nih.gov/compound/Zuclopenthixol"},{"number":2,"id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/zuclopenthixol-uses-dosage-side-effects#zuclopenthixol-acetate-acute-schizophrenia-similar-serious-mental-illnesses","text":"Jayakody, K., Gibson, R.C., Kumar, A., & Gunadasa, S. (2012). Zuclopenthixol acetate for acute schizophrenia and similar serious mental illnesses. Cochrane Database of Systematic Reviews, 4. 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