{"formatVersion":"1.1","id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects","path":"/library/duloxetine-uses-dosage-side-effects","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects","title":"Duloxetine (Cymbalta)","family":"Library detail","description":"Duloxetine, commonly sold under the brand name Cymbalta, is an SNRI antidepressant medication used to treat a range of medical conditions. Find out more here.","language":"en-US","access":{"audience":"custom-shared-preview","indexable":true},"provenance":{"sourceUrl":"https://www.mentalhealth.com/library/duloxetine-uses-dosage-side-effects","wordpressId":"390","contentCompleteness":"complete","dateScope":"original-source"},"authors":[{"@type":"Person","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/naomi-carr#person","name":"Naomi Carr","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/naomi-carr"}],"reviewer":{"@type":"Person","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/morgan-blair#person","name":"Morgan Blair","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/morgan-blair"},"dates":{"datePublished":"2023-02-20T11:07:31Z","dateModified":"2025-11-23T10:42:49Z","lastReviewed":"2023-02-20"},"content":{"html":"

Duloxetine (Cymbalta)

Written by \"\"Naomi CarrMedically reviewed by \"\"Morgan Blair

Published on · Updated on

Duloxetine, also known as Cymbalta, is an antidepressant medication, classified as a serotonin-norepinephrine reuptake inhibitor (SNRI), primarily used in the treatment of depression and generalized anxiety disorder. Take this medication exactly as prescribed and consult with your doctor before starting any other medication (prescribed or over the counter) while on duloxetine, as adverse effects can occur.

\"A

Key takeaways

  • Duloxetine is an SNRI used for depression, generalized anxiety disorder, and some pain conditions.
  • Treatment requires monitoring for side effects, mood changes, and potentially dangerous medication interactions.
  • Abrupt discontinuation can cause withdrawal symptoms, so stopping treatment requires prescriber guidance.

Duloxetine brand names

    \n
  • Cymbalta
    • \n
  • Drizalma Sprinkle
    • \n

What is duloxetine prescribed for?

\nDuloxetine is prescribed for the treatment of major depressive disorder, generalized anxiety disorder, diabetic peripheral neuropathic pain, fibromyalgia, and chronic musculoskeletal pain [1].\nDuloxetine is not typically prescribed to those under the age of 18, as the safety and effectiveness of the medication in this age group has not been determined. Also, the risk of developing suicidal thoughts while on this medication is higher in younger age groups [2].\n

How does duloxetine work?

\nDuloxetine works by affecting serotonin, norepinephrine, and dopamine. It creates an increased concentration of these neurotransmitters in the brain, which helps to improve mood, thereby reducing the symptoms of depression and anxiety [3][4].\nDuloxetine also has an effect on noradrenergic and serotonergic neurons and is believed to prevent pain signals from reaching the brain, thus reducing pain and making it an effective treatment for certain physical conditions [3].\n

How is duloxetine usually taken?

\nDuloxetine is available as a delayed release capsule in 20mg, 30mg, and 60mg strengths, and as a sprinkle capsule in 20mg, 30mg, 40mg, and 60mg strengths.\n

The sprinkle capsule can be opened and poured onto a soft food, such as applesauce, which must then be swallowed without chewing. The regular capsule must be swallowed whole, without being broken, crushed, or chewed.

Your treatment may begin with one or two daily doses but will typically be maintained at just one dose per day.

For the treatment of major depressive disorder, you may initially be prescribed two daily doses of 20mg, which can then be increased up to 60mg, to be taken as one dose. The maximum dose that can be prescribed is 120mg per day, although 60mg is generally an effective dose.

For the treatment of generalized anxiety disorder, your dose will likely begin at 60mg, to be taken once per day. Again, the maximum dose is 120mg per day, although 60mg is generally effective [2][4].

For the treatment of diabetic peripheral neuropathic pain, fibromyalgia, and chronic musculoskeletal pain, the dose is typically started at 30mg once per day for one week, then increased to 60mg once per day. Higher doses are not advised for these medical conditions, due to increased risk of side effects [2].

\nThis medication should be taken as prescribed, without missing a dose. If a dose is missed, take the medication as soon as possible, or if it is close to the next dosage time, skip the missed dose. Never take duloxetine without proper medical advice, and never double your prescribed dose in one go, as this can have adverse effects and may increase the risk of side effects.\n

How long does duloxetine stay in your system?

\nAfter you begin taking this medication, you may notice some improvements in your symptoms within the first week or two, but it will likely take several weeks, or up to three months of treatment, for duloxetine to take full effect, so it is important to continue taking it as prescribed to ensure it is effective [1].\n

After you stop taking duloxetine, it may take several days or weeks for the medication to entirely leave your system [2].

\nDo not suddenly stop taking duloxetine, even if you feel better, as this can have a serious impact on your physical and mental health and can cause an increase in symptoms of depression. If your doctor advises that it is safe to come off this medication, they will likely reduce your prescription slowly, to prevent adverse effects.\n

Duloxetine side effects

\nWhen you begin a new medication, you may experience some common side effects. They will likely reduce within the first week or two, but if they continue or become problematic, consult with your doctor immediately, as you may need a reduced dose or a change of medication.\nCommon side effects of duloxetine include [1][4]:\n

    \n
  • Abdominal pain, including nausea, vomiting, diarrhea, or constipation
    • \n
  • Changes in appetite or weight
    • \n
  • Sweating
    • \n
  • Restlessness
    • \n
  • Dry mouth
    • \n
  • Trouble sleeping
    • \n
  • Dizziness
    • \n
  • Headache
    • \n
  • Shaking
    • \n
  • Sexual dysfunction
    • \n

\nSerious side effects and allergic reactions to duloxetine are less common but may still occur. Contact your doctor immediately if you experience any of the following [2][4]:\n

    \n
  • Yellowing of the skin or eyes
    • \n
  • Dark urine
    • \n
  • Pain or swelling in the abdomen
    • \n
  • Unexplained or unusual bleeding
    • \n
  • Extreme fatigue
    • \n
  • Muscle pain, stiffness, or weakness
    • \n
  • Fever or flu-like symptoms
    • \n
  • Rapid or irregular heartbeat
    • \n
  • Difficulty breathing or swallowing
    • \n
  • Rash, hives, or blisters
    • \n
  • Swelling on any part of the face or body
    • \n
  • Changes in vision
    • \n
  • Seizures
    • \n
  • Changes in mental state, including hallucinations, delusions, agitation, aggression, mania, or suicidal thoughts
    • \n

Duloxetine precautions

\nDuloxetine can cause an increase in suicidal thoughts, particularly at the beginning of your treatment. This risk has been found to be higher in people under the age of 24 years old [2]. If you or your family notice any concerning changes in your mental state, or you experience any thoughts of harming yourself, contact your doctor or mental health professional immediately.\n

It is important that your doctor is aware of any past or present mental health conditions you have experienced, to enable safe monitoring of your condition while on this medication, or to decide if it is safe for you.

Your doctor may wish to screen you for bipolar disorder prior to starting duloxetine, as there is a risk of antidepressant medication prompting a manic episode in those with bipolar [1].

Discuss with your doctor all your past and present physical health conditions, as they may impact your ability to take this medication safely.

Ensure you tell your doctor if you have experienced any kidney, liver, or heart disease, seizures, serious stomach or blood conditions, glaucoma, or diabetes, as it may not be safe for you to take this medication because of potential side effects [2]. Alternatively, your doctor may wish to prescribe a lower dose and closely monitor your physical health during your treatment.

Discuss with your doctor if you are pregnant or planning to become pregnant, as there is a risk of premature birth if duloxetine is taken in the second and third trimester [1]. It is important that you are aware of the risks to you and your baby that may occur with and without medication, and can make an informed decision about your treatment.

Ensure your doctor is aware if you are breastfeeding, as duloxetine can be excreted in breast milk in small amounts, so there are risks to using this medication while breastfeeding. However, if medication is necessary for your treatment, it is advised to monitor your baby for any concerning changes in their mental or physical state [3].

Depending on your prescription and the length of time you have been on this treatment, you may experience withdrawal symptoms when coming off this medication [5]. Your doctor will likely reduce your prescription slowly to prevent this. Taking duloxetine exactly as prescribed by your doctor can also help to prevent withdrawal symptoms.

This medication can cause drowsiness and sedation, so it is important to avoid driving until you are aware of how duloxetine affects you and it is safe to do so.

\nTell your doctor about all medications you are currently taking, or plan to take (including vitamins and dietary supplements), as they may cause adverse reactions.\n

Duloxetine interactions

\nCertain antidepressant medications, called monoamine oxide inhibitors (MAOIs), should not be taken with duloxetine, due to the increased risk of serotonin syndrome. There should be a space of at least 14 days between doses of an MAOI and duloxetine [1].\n

Some medications may interact with duloxetine, impacting the effectiveness of your medication or increasing the risk of side effects. This includes amphetamines, anti-inflammatory medications, blood thinners, diuretics, medications for heart conditions, seizures, migraines, nausea, and chronic pain, sedatives, tranquilizers, and other mental health medications, including antidepressants and anti-anxiety medications [4].

St John’s wort and tryptophan can also interact with duloxetine, potentially causing adverse effects.

\nAlways discuss your medications with your doctor before starting a new treatment.\n

Duloxetine storage

\nAlways keep all medications out of reach of children.\n

Store duloxetine in its original packaging, in airtight containers, and at room temperature (never above 86°F).

\nIf you need to dispose of medication that is out of date or no longer needed, contact a medical professional to ensure it is disposed of appropriately. Never flush medications down the toilet or throw them in the trash, as this can create unnecessary risks.\n

What to do if you overdose on duloxetine

\nIf you overdose on duloxetine, call a medical professional, or Poison Control on 1-800-222-1222, or in case of an emergency, call 911. Symptoms of a duloxetine overdose may include fast or irregular heartbeat, hallucinations, fever, seizure, vomiting, confusion, or coma.\n

Frequently asked questions about duloxetine

Does duloxetine cause weight gain?

\nDuloxetine has been found to cause weight loss in short-term use and is not generally considered to cause excessive weight gain [2]. Studies into the long-term use of duloxetine have found that it may cause slight weight gain, particularly in those with a low BMI prior to treatment, but suggests that it may improve low appetite, rather than the medication itself causing an increase in weight [6].\n

Does duloxetine cause withdrawal symptoms?

\nDepending on the dosage and length of treatment, duloxetine can cause withdrawal symptoms when discontinuing treatment, which may include dizziness, nausea, nightmares, and irritability [5].\n

The risk of withdrawal symptoms is higher if you suddenly stop taking duloxetine, so your doctor will gradually reduce your prescription if it is deemed safe to discontinue your treatment, as this can help to prevent withdrawal symptoms. Taking your medication exactly as prescribed by your doctor can also help to prevent unwanted effects [1].

References

    \n
  1. The College of Psychiatric and Neurologic Pharmacists (CPNP) and the National Alliance on Mental Illness (NAMI). (Updated 2016). Duloxetine (Cymbalta). NAMI. Retrieved from NAMI
    2. \n
  2. Eli Lilly and Company. (Revised 2008). Cymbalta (Duloxetine Hydrochloride) Capsules Medication Guide. Access FDA. Retrieved from U.S. Food and Drug Administration
    3. \n
  3. Dhaliwal, J.S., Spurling, B.C., & Molla, M. (2022). Duloxetine. In StatPearls [Internet]. Treasure Island, FL: StatPearls Publishing. Retrieved from National Library of Medicine
    4. \n
  4. American Society of Health-System Pharmacists, Inc. (Revised 2022). Duloxetine. MedlinePlus. Retrieved from MedlinePlus
    5. \n
  5. Perahia, D.G., Kajdasz, D.K., Desaiah, D., & Haddad, P.M. (2005). Symptoms Following Abrupt Discontinuation of Duloxetine Treatment in Patients with Major Depressive Disorder. Journal of Affective Disorders, 89(1-3), 207–212. Retrieved from Symptoms Following Abrupt Discontinuation of Duloxetine Treatment in Patients with…
    6. \n
  6. Wise, T.N., Perahia, D.G., Pangallo, B.A., Losin, W.G., & Wiltse, C.G. (2006). Effects of the Antidepressant Duloxetine on Body Weight: Analyses of 10 Clinical Studies. Primary Care Companion to the Journal of Clinical Psychiatry, 8(5), 269–278. Retrieved from Effects of the Antidepressant Duloxetine on Body Weight
    7. \n

Medical Content

The Clinical Affairs Team at MentalHealth.com is a dedicated group of medical professionals with diverse and extensive clinical experience. They actively contribute to the development of content, products, and services, and meticulously review all medical material before publication to ensure accuracy and alignment with current research and conversations in mental health. For more information, please visit the Editorial Policy.

About MentalHealth.com

MentalHealth.com helps people understand themselves, build healthier relationships, and access the right care. We bring together mental health education, diagnostics, and care management to support well-being throughout every phase of life.

\"\"

Author

Naomi Carr

Writer

Naomi Carr is a writer with a background in English Literature from Oxford Brookes University.

Published
Updated
\"\"

Medical Reviewer

Morgan Blair

MA, LPCC

Morgan Blair is a licensed therapist, writer and medical reviewer, holding a master’s degree in clinical mental health counseling from Northwestern University.

Reviewed

Subject matter expert

\"\"

Leila Khurshid, Pharm.D.

Clinical pharmacy and medication

View experience
\"\"

Related communities

Medications

Explore questions and perspectives about psychiatric medications and the treatment experience.

Explore community
","text":"HomeLibraryMedicationsDuloxetine (Cymbalta)Duloxetine (Cymbalta)Written by Naomi CarrMedically reviewed by Morgan BlairPublished on February 20, 2023 · Updated on November 23, 2025Duloxetine, also known as Cymbalta, is an antidepressant medication, classified as a serotonin-norepinephrine reuptake inhibitor (SNRI), primarily used in the treatment of depression and generalized anxiety disorder. Take this medication exactly as prescribed and consult with your doctor before starting any other medication (prescribed or over the counter) while on duloxetine, as adverse effects can occur.Key takeawaysDuloxetine is an SNRI used for depression, generalized anxiety disorder, and some pain conditions.Treatment requires monitoring for side effects, mood changes, and potentially dangerous medication interactions.Abrupt discontinuation can cause withdrawal symptoms, so stopping treatment requires prescriber guidance.Duloxetine brand names Cymbalta Drizalma Sprinkle What is duloxetine prescribed for? Duloxetine is prescribed for the treatment of major depressive disorder, generalized anxiety disorder, diabetic peripheral neuropathic pain, fibromyalgia, and chronic musculoskeletal pain [1]. Duloxetine is not typically prescribed to those under the age of 18, as the safety and effectiveness of the medication in this age group has not been determined. Also, the risk of developing suicidal thoughts while on this medication is higher in younger age groups [2]. How does duloxetine work? Duloxetine works by affecting serotonin, norepinephrine, and dopamine. It creates an increased concentration of these neurotransmitters in the brain, which helps to improve mood, thereby reducing the symptoms of depression and anxiety [3][4]. Duloxetine also has an effect on noradrenergic and serotonergic neurons and is believed to prevent pain signals from reaching the brain, thus reducing pain and making it an effective treatment for certain physical conditions [3]. How is duloxetine usually taken? Duloxetine is available as a delayed release capsule in 20mg, 30mg, and 60mg strengths, and as a sprinkle capsule in 20mg, 30mg, 40mg, and 60mg strengths. The sprinkle capsule can be opened and poured onto a soft food, such as applesauce, which must then be swallowed without chewing. The regular capsule must be swallowed whole, without being broken, crushed, or chewed.Your treatment may begin with one or two daily doses but will typically be maintained at just one dose per day.For the treatment of major depressive disorder, you may initially be prescribed two daily doses of 20mg, which can then be increased up to 60mg, to be taken as one dose. The maximum dose that can be prescribed is 120mg per day, although 60mg is generally an effective dose.For the treatment of generalized anxiety disorder, your dose will likely begin at 60mg, to be taken once per day. Again, the maximum dose is 120mg per day, although 60mg is generally effective [2][4].For the treatment of diabetic peripheral neuropathic pain, fibromyalgia, and chronic musculoskeletal pain, the dose is typically started at 30mg once per day for one week, then increased to 60mg once per day. Higher doses are not advised for these medical conditions, due to increased risk of side effects [2]. This medication should be taken as prescribed, without missing a dose. If a dose is missed, take the medication as soon as possible, or if it is close to the next dosage time, skip the missed dose. Never take duloxetine without proper medical advice, and never double your prescribed dose in one go, as this can have adverse effects and may increase the risk of side effects. How long does duloxetine stay in your system? After you begin taking this medication, you may notice some improvements in your symptoms within the first week or two, but it will likely take several weeks, or up to three months of treatment, for duloxetine to take full effect, so it is important to continue taking it as prescribed to ensure it is effective [1]. After you stop taking duloxetine, it may take several days or weeks for the medication to entirely leave your system [2]. Do not suddenly stop taking duloxetine, even if you feel better, as this can have a serious impact on your physical and mental health and can cause an increase in symptoms of depression. If your doctor advises that it is safe to come off this medication, they will likely reduce your prescription slowly, to prevent adverse effects. Duloxetine side effects When you begin a new medication, you may experience some common side effects. They will likely reduce within the first week or two, but if they continue or become problematic, consult with your doctor immediately, as you may need a reduced dose or a change of medication. Common side effects of duloxetine include [1][4]: Abdominal pain, including nausea, vomiting, diarrhea, or constipation Changes in appetite or weight Sweating Restlessness Dry mouth Trouble sleeping Dizziness Headache Shaking Sexual dysfunction Serious side effects and allergic reactions to duloxetine are less common but may still occur. Contact your doctor immediately if you experience any of the following [2][4]: Yellowing of the skin or eyes Dark urine Pain or swelling in the abdomen Unexplained or unusual bleeding Extreme fatigue Muscle pain, stiffness, or weakness Fever or flu-like symptoms Rapid or irregular heartbeat Difficulty breathing or swallowing Rash, hives, or blisters Swelling on any part of the face or body Changes in vision Seizures Changes in mental state, including hallucinations, delusions, agitation, aggression, mania, or suicidal thoughts Duloxetine precautions Duloxetine can cause an increase in suicidal thoughts, particularly at the beginning of your treatment. This risk has been found to be higher in people under the age of 24 years old [2]. If you or your family notice any concerning changes in your mental state, or you experience any thoughts of harming yourself, contact your doctor or mental health professional immediately. It is important that your doctor is aware of any past or present mental health conditions you have experienced, to enable safe monitoring of your condition while on this medication, or to decide if it is safe for you.Your doctor may wish to screen you for bipolar disorder prior to starting duloxetine, as there is a risk of antidepressant medication prompting a manic episode in those with bipolar [1].Discuss with your doctor all your past and present physical health conditions, as they may impact your ability to take this medication safely.Ensure you tell your doctor if you have experienced any kidney, liver, or heart disease, seizures, serious stomach or blood conditions, glaucoma, or diabetes, as it may not be safe for you to take this medication because of potential side effects [2]. Alternatively, your doctor may wish to prescribe a lower dose and closely monitor your physical health during your treatment.Discuss with your doctor if you are pregnant or planning to become pregnant, as there is a risk of premature birth if duloxetine is taken in the second and third trimester [1]. It is important that you are aware of the risks to you and your baby that may occur with and without medication, and can make an informed decision about your treatment.Ensure your doctor is aware if you are breastfeeding, as duloxetine can be excreted in breast milk in small amounts, so there are risks to using this medication while breastfeeding. However, if medication is necessary for your treatment, it is advised to monitor your baby for any concerning changes in their mental or physical state [3].Depending on your prescription and the length of time you have been on this treatment, you may experience withdrawal symptoms when coming off this medication [5]. Your doctor will likely reduce your prescription slowly to prevent this. Taking duloxetine exactly as prescribed by your doctor can also help to prevent withdrawal symptoms.This medication can cause drowsiness and sedation, so it is important to avoid driving until you are aware of how duloxetine affects you and it is safe to do so. Tell your doctor about all medications you are currently taking, or plan to take (including vitamins and dietary supplements), as they may cause adverse reactions. Duloxetine interactions Certain antidepressant medications, called monoamine oxide inhibitors (MAOIs), should not be taken with duloxetine, due to the increased risk of serotonin syndrome. There should be a space of at least 14 days between doses of an MAOI and duloxetine [1]. Some medications may interact with duloxetine, impacting the effectiveness of your medication or increasing the risk of side effects. This includes amphetamines, anti-inflammatory medications, blood thinners, diuretics, medications for heart conditions, seizures, migraines, nausea, and chronic pain, sedatives, tranquilizers, and other mental health medications, including antidepressants and anti-anxiety medications [4].St John’s wort and tryptophan can also interact with duloxetine, potentially causing adverse effects. Always discuss your medications with your doctor before starting a new treatment. Duloxetine storage Always keep all medications out of reach of children. Store duloxetine in its original packaging, in airtight containers, and at room temperature (never above 86°F). If you need to dispose of medication that is out of date or no longer needed, contact a medical professional to ensure it is disposed of appropriately. Never flush medications down the toilet or throw them in the trash, as this can create unnecessary risks. What to do if you overdose on duloxetine If you overdose on duloxetine, call a medical professional, or Poison Control on 1-800-222-1222, or in case of an emergency, call 911. Symptoms of a duloxetine overdose may include fast or irregular heartbeat, hallucinations, fever, seizure, vomiting, confusion, or coma. Frequently asked questions about duloxetineDoes duloxetine cause weight gain? Duloxetine has been found to cause weight loss in short-term use and is not generally considered to cause excessive weight gain [2]. Studies into the long-term use of duloxetine have found that it may cause slight weight gain, particularly in those with a low BMI prior to treatment, but suggests that it may improve low appetite, rather than the medication itself causing an increase in weight [6]. Does duloxetine cause withdrawal symptoms? Depending on the dosage and length of treatment, duloxetine can cause withdrawal symptoms when discontinuing treatment, which may include dizziness, nausea, nightmares, and irritability [5]. The risk of withdrawal symptoms is higher if you suddenly stop taking duloxetine, so your doctor will gradually reduce your prescription if it is deemed safe to discontinue your treatment, as this can help to prevent withdrawal symptoms. Taking your medication exactly as prescribed by your doctor can also help to prevent unwanted effects [1].References The College of Psychiatric and Neurologic Pharmacists (CPNP) and the National Alliance on Mental Illness (NAMI). (Updated 2016). Duloxetine (Cymbalta). NAMI. Retrieved from NAMI Eli Lilly and Company. (Revised 2008). Cymbalta (Duloxetine Hydrochloride) Capsules Medication Guide. Access FDA. Retrieved from U.S. Food and Drug Administration Dhaliwal, J.S., Spurling, B.C., & Molla, M. (2022). Duloxetine. In StatPearls [Internet]. Treasure Island, FL: StatPearls Publishing. Retrieved from National Library of Medicine American Society of Health-System Pharmacists, Inc. (Revised 2022). Duloxetine. MedlinePlus. Retrieved from MedlinePlus Perahia, D.G., Kajdasz, D.K., Desaiah, D., & Haddad, P.M. (2005). Symptoms Following Abrupt Discontinuation of Duloxetine Treatment in Patients with Major Depressive Disorder. Journal of Affective Disorders, 89(1-3), 207–212. Retrieved from Symptoms Following Abrupt Discontinuation of Duloxetine Treatment in Patients with… Wise, T.N., Perahia, D.G., Pangallo, B.A., Losin, W.G., & Wiltse, C.G. (2006). Effects of the Antidepressant Duloxetine on Body Weight: Analyses of 10 Clinical Studies. Primary Care Companion to the Journal of Clinical Psychiatry, 8(5), 269–278. Retrieved from Effects of the Antidepressant Duloxetine on Body Weight Medical ContentThe Clinical Affairs Team at MentalHealth.com is a dedicated group of medical professionals with diverse and extensive clinical experience. They actively contribute to the development of content, products, and services, and meticulously review all medical material before publication to ensure accuracy and alignment with current research and conversations in mental health. For more information, please visit the Editorial Policy.About MentalHealth.comMentalHealth.com helps people understand themselves, build healthier relationships, and access the right care. We bring together mental health education, diagnostics, and care management to support well-being throughout every phase of life.AuthorNaomi CarrWriterNaomi Carr is a writer with a background in English Literature from Oxford Brookes University.PublishedFebruary 20, 2023UpdatedNovember 23, 2025Medical ReviewerMorgan BlairMA, LPCCMorgan Blair is a licensed therapist, writer and medical reviewer, holding a master’s degree in clinical mental health counseling from Northwestern University.ReviewedFebruary 20, 2023Subject matter expertLeila Khurshid, Pharm.D.Clinical pharmacy and medicationView experienceRelated communitiesMedicationsExplore questions and perspectives about psychiatric medications and the treatment experience.Explore communityTable of contentsChoose a sectionDuloxetine brand namesWhat is duloxetine prescribed for?How does duloxetine work?How is duloxetine usually taken?How long does duloxetine stay in your system?Duloxetine side effectsDuloxetine precautionsDuloxetine interactionsDuloxetine storageWhat to do if you overdose on duloxetineFrequently asked questions about duloxetineView moreSubject matter expertLeila Khurshid, Pharm.D.Clinical pharmacy and medicationView experienceRelated communitiesMedicationsExplore questions and perspectives about psychiatric medications and the treatment experience.Explore community","wordCount":2083},"schema":{"@context":"https://schema.org","@graph":[{"@type":"Organization","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/#organization","name":"MentalHealth.com","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/"},{"@type":"WebSite","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/#website","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/","name":"MentalHealth.com","inLanguage":"en-US","publisher":{"@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/#organization"}},{"@type":"BreadcrumbList","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://mentalhealth-v2.workspace-454808.chatgpt.site/"},{"@type":"ListItem","position":2,"name":"Library","item":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library"},{"@type":"ListItem","position":3,"name":"Medications","item":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/medications"},{"@type":"ListItem","position":4,"name":"Duloxetine (Cymbalta)","item":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects"}]},{"@type":"ImageObject","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#primaryimage","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/optimized/3eeba4818741bd28551f3b2d.webp","contentUrl":"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/optimized/3eeba4818741bd28551f3b2d.webp","width":1200,"height":800,"encodingFormat":"image/webp","caption":"A healthcare professional listens to a woman in a consultation room."},{"@type":"Person","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/naomi-carr#person","name":"Naomi Carr","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/naomi-carr","jobTitle":"Writer","image":"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/optimized/47686b37ff1465ff6711c0b5.jpg","sameAs":["https://www.linkedin.com/in/naomi-carr-07784590/"]},{"@type":"Person","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/morgan-blair#person","name":"Morgan Blair","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/morgan-blair","jobTitle":"MA, LPCC","image":"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/optimized/9f1be5c5cc2b412cfab5f6cc.jpg","sameAs":["https://www.linkedin.com/in/morgan-blair-5627aa88/"]},{"@type":"Article","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#article","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects","headline":"Duloxetine (Cymbalta)","description":"Duloxetine, commonly sold under the brand name Cymbalta, is an SNRI antidepressant medication used to treat a range of medical conditions. Find out more here.","wordCount":1697,"mainEntityOfPage":{"@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#webpage"},"publisher":{"@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/#organization"},"articleSection":"Library","citation":[{"@type":"CreativeWork","name":"The College of Psychiatric and Neurologic Pharmacists (CPNP) and the National Alliance on Mental Illness (NAMI). (Updated 2016). Duloxetine (Cymbalta). NAMI. Retrieved from NAMI","url":"https://www.nami.org/treatments-and-approaches/mental-health-medications/types-of-medication/duloxetine-(cymbalta/"},{"@type":"CreativeWork","name":"Eli Lilly and Company. (Revised 2008). Cymbalta (Duloxetine Hydrochloride) Capsules Medication Guide. Access FDA. Retrieved from U.S. Food and Drug Administration","url":"https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/022516lbl.pdf"},{"@type":"CreativeWork","name":"Dhaliwal, J.S., Spurling, B.C., & Molla, M. (2022). Duloxetine. In StatPearls [Internet]. Treasure Island, FL: StatPearls Publishing. Retrieved from National Library of Medicine","url":"https://www.ncbi.nlm.nih.gov/books/NBK549806/"},{"@type":"CreativeWork","name":"American Society of Health-System Pharmacists, Inc. (Revised 2022). Duloxetine. MedlinePlus. Retrieved from MedlinePlus","url":"https://medlineplus.gov/druginfo/meds/a604030.html"},{"@type":"CreativeWork","name":"Perahia, D.G., Kajdasz, D.K., Desaiah, D., & Haddad, P.M. (2005). Symptoms Following Abrupt Discontinuation of Duloxetine Treatment in Patients with Major Depressive Disorder. Journal of Affective Disorders, 89(1-3), 207–212. Retrieved from Symptoms Following Abrupt Discontinuation of Duloxetine Treatment in Patients with…","url":"https://doi.org/10.1016/j.jad.2005.09.003"},{"@type":"CreativeWork","name":"Wise, T.N., Perahia, D.G., Pangallo, B.A., Losin, W.G., & Wiltse, C.G. (2006). Effects of the Antidepressant Duloxetine on Body Weight: Analyses of 10 Clinical Studies. Primary Care Companion to the Journal of Clinical Psychiatry, 8(5), 269–278. Retrieved from Effects of the Antidepressant Duloxetine on Body Weight","url":"https://doi.org/10.4088/pcc.v08n0503"}],"inLanguage":"en-US","datePublished":"2023-02-20T11:07:31Z","dateModified":"2025-11-23T10:42:49Z","author":[{"@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/naomi-carr#person"}],"image":{"@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#primaryimage"}},{"@type":"MedicalWebPage","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#webpage","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects","name":"Duloxetine (Cymbalta)","description":"Duloxetine, commonly sold under the brand name Cymbalta, is an SNRI antidepressant medication used to treat a range of medical conditions. Find out more here.","inLanguage":"en-US","isPartOf":{"@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/#website"},"breadcrumb":{"@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#breadcrumb"},"mainEntity":{"@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#article"},"relatedLink":["https://mentalhealth-v2.workspace-454808.chatgpt.site/library/clonazepam-uses-dosage-side-effects","https://mentalhealth-v2.workspace-454808.chatgpt.site/library/mirtazapine-uses-dosage-side-effects","https://mentalhealth-v2.workspace-454808.chatgpt.site/library/primidone-uses-dosage-side-effects","https://mentalhealth-v2.workspace-454808.chatgpt.site/library/atenolol-uses-dosage-side-effects","https://mentalhealth-v2.workspace-454808.chatgpt.site/library/sertraline-uses-dosage-side-effects","https://mentalhealth-v2.workspace-454808.chatgpt.site/people/leila-khurshid"],"publisher":{"@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/#organization"},"medicalAudience":{"@type":"MedicalAudience","audienceType":"General public"},"datePublished":"2023-02-20T11:07:31Z","dateModified":"2025-11-23T10:42:49Z","lastReviewed":"2023-02-20","primaryImageOfPage":{"@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#primaryimage"},"image":{"@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#primaryimage"},"reviewedBy":{"@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/morgan-blair#person"}}]},"representations":{"html":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects","json":"https://mentalhealth-v2.workspace-454808.chatgpt.site/data/library/duloxetine-uses-dosage-side-effects.json","jsonLd":"https://mentalhealth-v2.workspace-454808.chatgpt.site/data/library/duloxetine-uses-dosage-side-effects.ld.json"},"$schema":"https://mentalhealth-v2.workspace-454808.chatgpt.site/data/page.schema.json","images":[{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/optimized/47686b37ff1465ff6711c0b5.jpg","alt":"","width":22,"height":22},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/optimized/9f1be5c5cc2b412cfab5f6cc.jpg","alt":"","width":22,"height":22},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/optimized/3eeba4818741bd28551f3b2d.webp","alt":"A healthcare professional listens to a woman in a consultation room.","width":1200,"height":800},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/optimized/90339bb61ace127cee8df5f2.webp","alt":"","width":64,"height":64},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/optimized/9ae511a8c567ef6fdff00197.webp","alt":"","width":48,"height":48}],"sections":[{"id":"key-takeaways","title":"Key takeaways","level":2,"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#key-takeaways"},{"id":"duloxetine-brand-names","title":"Duloxetine brand names","level":2,"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#duloxetine-brand-names"},{"id":"what-is-duloxetine-prescribed-for","title":"What is duloxetine prescribed for?","level":2,"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#what-is-duloxetine-prescribed-for"},{"id":"how-does-duloxetine-work","title":"How does duloxetine work?","level":2,"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#how-does-duloxetine-work"},{"id":"how-is-duloxetine-usually-taken","title":"How is duloxetine usually taken?","level":2,"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#how-is-duloxetine-usually-taken"},{"id":"how-long-does-duloxetine-stay-in-your-system","title":"How long does duloxetine stay in your system?","level":2,"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#how-long-does-duloxetine-stay-in-your-system"},{"id":"duloxetine-side-effects","title":"Duloxetine side effects","level":2,"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#duloxetine-side-effects"},{"id":"duloxetine-precautions","title":"Duloxetine precautions","level":2,"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#duloxetine-precautions"},{"id":"duloxetine-interactions","title":"Duloxetine interactions","level":2,"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#duloxetine-interactions"},{"id":"duloxetine-storage","title":"Duloxetine storage","level":2,"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#duloxetine-storage"},{"id":"what-to-do-if-you-overdose-on-duloxetine","title":"What to do if you overdose on duloxetine","level":2,"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#what-to-do-if-you-overdose-on-duloxetine"},{"id":"frequently-asked-questions-about-duloxetine","title":"Frequently asked questions about duloxetine","level":2,"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#frequently-asked-questions-about-duloxetine"},{"id":"does-duloxetine-cause-weight-gain-duloxetine-has-been-found-to-cause-weight-loss-in-short-term-use-and-is-not-generally-considered-to-cause-excessive-weight-gain","title":"Does duloxetine cause weight gain?","level":3,"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#does-duloxetine-cause-weight-gain-duloxetine-has-been-found-to-cause-weight-loss-in-short-term-use-and-is-not-generally-considered-to-cause-excessive-weight-gain"},{"id":"does-duloxetine-cause-withdrawal-symptoms-depending-on-the-dosage-and-length-of-treatment-duloxetine-can-cause-withdrawal-symptoms-when-discontinuing-treatment-which-may-include-dizziness-nausea-nightmares-and-irritability","title":"Does duloxetine cause withdrawal symptoms?","level":3,"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#does-duloxetine-cause-withdrawal-symptoms-depending-on-the-dosage-and-length-of-treatment-duloxetine-can-cause-withdrawal-symptoms-when-discontinuing-treatment-which-may-include-dizziness-nausea-nightmares-and-irritability"},{"id":"references-2","title":"References","level":2,"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#references-2"},{"id":"medical-content","title":"Medical Content","level":2,"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#medical-content"},{"id":"about-mentalhealth-com","title":"About MentalHealth.com","level":2,"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#about-mentalhealth-com"},{"id":"naomi-carr","title":"Naomi Carr","level":3,"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#naomi-carr"},{"id":"morgan-blair","title":"Morgan Blair","level":3,"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#morgan-blair"}],"references":[{"number":1,"id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#duloxetine-cymbalta","text":"The College of Psychiatric and Neurologic Pharmacists (CPNP) and the National Alliance on Mental Illness (NAMI). (Updated 2016). Duloxetine (Cymbalta). NAMI. Retrieved from NAMI","links":[{"url":"https://www.nami.org/treatments-and-approaches/mental-health-medications/types-of-medication/duloxetine-(cymbalta/?utm_medium=referral&utm_campaign=libra&utm_content=external_resource&utm_id=site-library-duloxetine-uses-dosage-side-effects&utm_source=mentalhealth.com","label":"NAMI"}],"url":"https://www.nami.org/treatments-and-approaches/mental-health-medications/types-of-medication/duloxetine-(cymbalta/?utm_medium=referral&utm_campaign=libra&utm_content=external_resource&utm_id=site-library-duloxetine-uses-dosage-side-effects&utm_source=mentalhealth.com"},{"number":2,"id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#cymbalta-duloxetine-hydrochloride-capsules-medication-guide","text":"Eli Lilly and Company. (Revised 2008). Cymbalta (Duloxetine Hydrochloride) Capsules Medication Guide. Access FDA. Retrieved from U.S. Food and Drug Administration","links":[{"url":"https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/022516lbl.pdf?utm_medium=referral&utm_campaign=libra&utm_content=external_resource&utm_id=site-library-duloxetine-uses-dosage-side-effects&utm_source=mentalhealth.com","label":"U.S. Food and Drug Administration"}],"url":"https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/022516lbl.pdf?utm_medium=referral&utm_campaign=libra&utm_content=external_resource&utm_id=site-library-duloxetine-uses-dosage-side-effects&utm_source=mentalhealth.com"},{"number":3,"id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#duloxetine","text":"Dhaliwal, J.S., Spurling, B.C., & Molla, M. (2022). Duloxetine. In StatPearls [Internet]. Treasure Island, FL: StatPearls Publishing. Retrieved from National Library of Medicine","links":[{"url":"https://www.ncbi.nlm.nih.gov/books/NBK549806/?utm_medium=referral&utm_campaign=libra&utm_content=external_resource&utm_id=site-library-duloxetine-uses-dosage-side-effects&utm_source=mentalhealth.com","label":"National Library of Medicine"}],"url":"https://www.ncbi.nlm.nih.gov/books/NBK549806/?utm_medium=referral&utm_campaign=libra&utm_content=external_resource&utm_id=site-library-duloxetine-uses-dosage-side-effects&utm_source=mentalhealth.com"},{"number":4,"id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#duloxetine-source","text":"American Society of Health-System Pharmacists, Inc. (Revised 2022). Duloxetine. MedlinePlus. Retrieved from MedlinePlus","links":[{"url":"https://medlineplus.gov/druginfo/meds/a604030.html?utm_medium=referral&utm_campaign=libra&utm_content=external_resource&utm_id=site-library-duloxetine-uses-dosage-side-effects&utm_source=mentalhealth.com","label":"MedlinePlus"}],"url":"https://medlineplus.gov/druginfo/meds/a604030.html?utm_medium=referral&utm_campaign=libra&utm_content=external_resource&utm_id=site-library-duloxetine-uses-dosage-side-effects&utm_source=mentalhealth.com"},{"number":5,"id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#symptoms-following-abrupt-discontinuation-duloxetine-treatment-patients-major-depressive","text":"Perahia, D.G., Kajdasz, D.K., Desaiah, D., & Haddad, P.M. (2005). Symptoms Following Abrupt Discontinuation of Duloxetine Treatment in Patients with Major Depressive Disorder. Journal of Affective Disorders, 89(1-3), 207–212. Retrieved from Symptoms Following Abrupt Discontinuation of Duloxetine Treatment in Patients with…","links":[{"url":"https://doi.org/10.1016/j.jad.2005.09.003?utm_medium=referral&utm_campaign=libra&utm_content=external_resource&utm_id=site-library-duloxetine-uses-dosage-side-effects&utm_source=mentalhealth.com","label":"Symptoms Following Abrupt Discontinuation of Duloxetine Treatment in Patients with…"}],"url":"https://doi.org/10.1016/j.jad.2005.09.003?utm_medium=referral&utm_campaign=libra&utm_content=external_resource&utm_id=site-library-duloxetine-uses-dosage-side-effects&utm_source=mentalhealth.com"},{"number":6,"id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#effects-antidepressant-duloxetine-body-weight-analyses-10-clinical-studies","text":"Wise, T.N., Perahia, D.G., Pangallo, B.A., Losin, W.G., & Wiltse, C.G. (2006). Effects of the Antidepressant Duloxetine on Body Weight: Analyses of 10 Clinical Studies. Primary Care Companion to the Journal of Clinical Psychiatry, 8(5), 269–278. Retrieved from Effects of the Antidepressant Duloxetine on Body Weight","links":[{"url":"https://doi.org/10.4088/pcc.v08n0503?utm_medium=referral&utm_campaign=libra&utm_content=external_resource&utm_id=site-library-duloxetine-uses-dosage-side-effects&utm_source=mentalhealth.com","label":"Effects of the Antidepressant Duloxetine on Body Weight"}],"url":"https://doi.org/10.4088/pcc.v08n0503?utm_medium=referral&utm_campaign=libra&utm_content=external_resource&utm_id=site-library-duloxetine-uses-dosage-side-effects&utm_source=mentalhealth.com"}],"relatedReading":[],"links":[{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/","label":"Home"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library","label":"Library"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/medications","label":"Medications"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/naomi-carr","label":"Naomi Carr"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/morgan-blair","label":"Morgan Blair"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/generalized-anxiety-disorder","label":"generalized anxiety disorder"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#duloxetine-cymbalta","label":"[1]"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#cymbalta-duloxetine-hydrochloride-capsules-medication-guide","label":"[2]"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#duloxetine","label":"[3]"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#duloxetine-source","label":"[4]"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#duloxetine","label":"[3]"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#cymbalta-duloxetine-hydrochloride-capsules-medication-guide","label":"[2]"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#duloxetine-source","label":"[4]"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#cymbalta-duloxetine-hydrochloride-capsules-medication-guide","label":"[2]"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#duloxetine-cymbalta","label":"[1]"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#cymbalta-duloxetine-hydrochloride-capsules-medication-guide","label":"[2]"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#duloxetine-cymbalta","label":"[1]"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#duloxetine-source","label":"[4]"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#cymbalta-duloxetine-hydrochloride-capsules-medication-guide","label":"[2]"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#duloxetine-source","label":"[4]"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#cymbalta-duloxetine-hydrochloride-capsules-medication-guide","label":"[2]"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#duloxetine-cymbalta","label":"[1]"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#cymbalta-duloxetine-hydrochloride-capsules-medication-guide","label":"[2]"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#duloxetine-cymbalta","label":"[1]"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#duloxetine","label":"[3]"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#symptoms-following-abrupt-discontinuation-duloxetine-treatment-patients-major-depressive","label":"[5]"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#duloxetine-cymbalta","label":"[1]"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#duloxetine-source","label":"[4]"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#cymbalta-duloxetine-hydrochloride-capsules-medication-guide","label":"[2]"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#effects-antidepressant-duloxetine-body-weight-analyses-10-clinical-studies","label":"[6]"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#symptoms-following-abrupt-discontinuation-duloxetine-treatment-patients-major-depressive","label":"[5]"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#duloxetine-cymbalta","label":"[1]"},{"url":"https://www.nami.org/treatments-and-approaches/mental-health-medications/types-of-medication/duloxetine-(cymbalta/?utm_medium=referral&utm_campaign=libra&utm_content=external_resource&utm_id=site-library-duloxetine-uses-dosage-side-effects&utm_source=mentalhealth.com","label":"NAMI"},{"url":"https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/022516lbl.pdf?utm_medium=referral&utm_campaign=libra&utm_content=external_resource&utm_id=site-library-duloxetine-uses-dosage-side-effects&utm_source=mentalhealth.com","label":"U.S. Food and Drug Administration"},{"url":"https://www.ncbi.nlm.nih.gov/books/NBK549806/?utm_medium=referral&utm_campaign=libra&utm_content=external_resource&utm_id=site-library-duloxetine-uses-dosage-side-effects&utm_source=mentalhealth.com","label":"National Library of Medicine"},{"url":"https://medlineplus.gov/druginfo/meds/a604030.html?utm_medium=referral&utm_campaign=libra&utm_content=external_resource&utm_id=site-library-duloxetine-uses-dosage-side-effects&utm_source=mentalhealth.com","label":"MedlinePlus"},{"url":"https://doi.org/10.1016/j.jad.2005.09.003?utm_medium=referral&utm_campaign=libra&utm_content=external_resource&utm_id=site-library-duloxetine-uses-dosage-side-effects&utm_source=mentalhealth.com","label":"Symptoms Following Abrupt Discontinuation of Duloxetine Treatment in Patients with…"},{"url":"https://doi.org/10.4088/pcc.v08n0503?utm_medium=referral&utm_campaign=libra&utm_content=external_resource&utm_id=site-library-duloxetine-uses-dosage-side-effects&utm_source=mentalhealth.com","label":"Effects of the Antidepressant Duloxetine on Body Weight"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/clinical-affairs","label":"The Clinical Affairs Team"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/publishing/editorial-policy","label":"Editorial Policy"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/naomi-carr","label":"Naomi Carr"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/morgan-blair","label":"Morgan Blair"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/leila-khurshid","label":"Leila Khurshid, Pharm.D."},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/leila-khurshid","label":"View experience"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/community/medications","label":"Explore community"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#duloxetine-brand-names","label":"Duloxetine brand names"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#what-is-duloxetine-prescribed-for","label":"What is duloxetine prescribed for?"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#how-does-duloxetine-work","label":"How does duloxetine work?"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#how-is-duloxetine-usually-taken","label":"How is duloxetine usually taken?"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#how-long-does-duloxetine-stay-in-your-system","label":"How long does duloxetine stay in your system?"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#duloxetine-side-effects","label":"Duloxetine side effects"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#duloxetine-precautions","label":"Duloxetine precautions"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#duloxetine-interactions","label":"Duloxetine interactions"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#duloxetine-storage","label":"Duloxetine storage"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#what-to-do-if-you-overdose-on-duloxetine","label":"What to do if you overdose on duloxetine"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects#frequently-asked-questions-about-duloxetine","label":"Frequently asked questions about duloxetine"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/leila-khurshid","label":"Leila Khurshid, Pharm.D."},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/leila-khurshid","label":"View experience"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/community/medications","label":"Explore community"}],"seo":{"title":"Duloxetine (Cymbalta) | MentalHealth.com","description":"Duloxetine, commonly sold under the brand name Cymbalta, is an SNRI antidepressant medication used to treat a range of medical conditions. Find out more here.","canonical":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects","robots":"index,follow","socialImage":{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/optimized/ec9b0cb47c0207d45e88634d.png","width":1200,"height":630,"alt":"MentalHealth.com — Library","type":"image/png","sitemapGroup":"library"}},"breadcrumbs":[{"name":"Home","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/"},{"name":"Library","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library"},{"name":"Medications","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/medications"},{"name":"Duloxetine (Cymbalta)","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/duloxetine-uses-dosage-side-effects"}],"subjectMatterExpert":{"name":"Leila Khurshid, Pharm.D.","url":"/people/leila-khurshid","profileId":"2317","topic":"medication","focus":"Clinical pharmacy and medication","selectionBasis":"Documented expertise in the existing published profile","reviewAttribution":false},"keyTakeaways":["Duloxetine is an SNRI used for depression, generalized anxiety disorder, and some pain conditions.","Treatment requires monitoring for side effects, mood changes, and potentially dangerous medication interactions.","Abrupt discontinuation can cause withdrawal symptoms, so stopping treatment requires prescriber guidance."],"introduction":{"html":"Duloxetine, also known as Cymbalta, is an antidepressant medication, classified as a serotonin-norepinephrine reuptake inhibitor (SNRI), primarily used in the treatment of depression and generalized anxiety disorder. Take this medication exactly as prescribed and consult with your doctor before starting any other medication (prescribed or over the counter) while on duloxetine, as adverse effects can occur.","text":"Duloxetine, also known as Cymbalta, is an antidepressant medication, classified as a serotonin-norepinephrine reuptake inhibitor (SNRI), primarily used in the treatment of depression and generalized anxiety disorder. Take this medication exactly as prescribed and consult with your doctor before starting any other medication (prescribed or over the counter) while on duloxetine, as adverse effects can occur.","sourceField":"hero"},"navigation":[{"label":"Duloxetine brand names","href":"#duloxetine-brand-names","heading":"Duloxetine brand names"},{"label":"What is duloxetine prescribed for?","href":"#what-is-duloxetine-prescribed-for","heading":"What is duloxetine prescribed for?"},{"label":"How does duloxetine work?","href":"#how-does-duloxetine-work","heading":"How does duloxetine work?"},{"label":"How is duloxetine usually taken?","href":"#how-is-duloxetine-usually-taken","heading":"How is duloxetine usually taken?"},{"label":"How long does duloxetine stay in your system?","href":"#how-long-does-duloxetine-stay-in-your-system","heading":"How long does duloxetine stay in your system?"},{"label":"Duloxetine side effects","href":"#duloxetine-side-effects","heading":"Duloxetine side effects"},{"label":"Duloxetine precautions","href":"#duloxetine-precautions","heading":"Duloxetine precautions"},{"label":"Duloxetine interactions","href":"#duloxetine-interactions","heading":"Duloxetine interactions"},{"label":"Duloxetine storage","href":"#duloxetine-storage","heading":"Duloxetine storage"},{"label":"What to do if you overdose on duloxetine","href":"#what-to-do-if-you-overdose-on-duloxetine","heading":"What to do if you overdose on duloxetine"},{"label":"Frequently asked questions about duloxetine","href":"#frequently-asked-questions-about-duloxetine","heading":"Frequently asked questions about duloxetine"}],"relatedCommunity":{"community":"/community/medications","basis":"topic match"},"referencePresentation":"Numbered author–date bibliography with linked source documents; n.d. denotes unavailable publication date.","collections":[]}