{"formatVersion":"1.1","id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics","path":"/library/can-you-overdose-on-antipsychotics","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics","title":"Antipsychotics and Overdose Risks","family":"Library detail","description":"Like almost any drug, it's possible to overdose on antipsychotic medications. Therefore, you should never take more than what is prescribed for you.","language":"en-US","access":{"audience":"custom-shared-preview","indexable":true},"provenance":{"sourceUrl":"https://www.mentalhealth.com/library/can-you-overdose-on-antipsychotics","wordpressId":"625","contentCompleteness":"complete","dateScope":"original-source"},"authors":[{"@type":"Person","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/leila-khurshid#person","name":"Leila Khurshid, Pharm.D.","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/leila-khurshid"}],"reviewer":{"@type":"Person","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/morgan-blair#person","name":"Morgan Blair","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/morgan-blair"},"dates":{"datePublished":"2023-09-29T12:20:15Z","dateModified":"2025-09-02T09:14:21Z","lastReviewed":"2023-09-29"},"content":{"html":"

Antipsychotics and Overdose Risks

Written by \"\"Leila Khurshid, Pharm.D.Medically reviewed by \"\"Morgan Blair

Published on · Updated on

Antipsychotic medications play a key role in treating conditions such as schizophrenia, bipolar disorder, and other psychiatric disorders.

However, understanding the potential risks associated with these medications is essential to ensure their safe and effective use. Navigating the realm of medication safety is a paramount concern for individuals managing their mental health and well-being.

One significant question that arises is whether it is possible to overdose on antipsychotics?

In this article, we will delve into the complexities of antipsychotic overdoses, examining factors that contribute to the risk of overdose, signs and symptoms to be aware of, and how to react during a potential overdose.

\"An

Key takeaways

  • Antipsychotic overdose can cause serious cardiovascular and nervous-system complications.
  • Excess doses and combinations with other substances can increase toxicity, with symptoms ranging from sedation to delirium or coma.
  • Suspected overdose requires prompt medical assessment, monitoring, and treatment to stabilize the person.

Is it possible to overdose on antipsychotics?

It is possible to overdose on antipsychotics and is a matter of vital importance. Antipsychotic medications, like many other types of medications, have a therapeutic range in which they are effective and safe. Taking an excessive dose of antipsychotics can lead to serious health risks and complications.

Patients can develop cardiotoxicity, seizures, or coma, requiring an admission to an intensive care unit. [1] These outcomes are associated with severe overdoses, with many antipsychotic overdoses resulting in mild sedation and patients being discharged six hours after the initial poisoning. [1] Nonetheless, people have died due to overdosing on atypical antipsychotics. [2]

Atypical antipsychotics, such as clozapine, risperidone, olanzapine, quetiapine, and ziprasidone, were made available for use in the late 1980s. [2] Deaths resulting from atypical antipsychotic overdose are often related to cardiovascular complications, but can also be the result of gastrointestinal, neurological, or endocrine issues. [2]

Since the late 1980s, morbidity and mortality from antipsychotic overdose has increased, with a 2016 Australian study showing that these increases occurred despite overall drug overdoses falling. [3] Olanzapine and quetiapine accounted for 78% of these overdoses, whist atypical antipsychotics generally made up most overdoses. [4]

How do antipsychotics cause toxicity?

Antipsychotics cause toxicity in multiple ways including obstructing potassium and sodium channels in the body, via alpha-1 adrenergic blockade and through anticholinergic effects. [4] Various organs are impacted but the cardiovascular and central nervous system are affected worse than any others. [4]

What factors contribute to antipsychotic overdose?

Understanding the factors that contribute to antipsychotic overdose is crucial for preventing overdose and promoting safe medication use. Here are some key contributors to antipsychotic overdose:

  • Dose and Medication Strength: Taking a higher dose of antipsychotic medication than prescribed significantly increases the risk of overdose. [2] Additionally, some formulations of antipsychotics may have higher concentrations, making them more potent.
  • Accidental Ingestion: Accidental ingestion can occur when someone, especially children, mistakenly ingests antipsychotic medication that was not stored securely or was mistaken for another medication.
  • Combining with Other Substances: Self-poisoning by mixing antipsychotic medications with alcohol, antidepressants, opioids, and other illicit drugs can potentiate the effects and increase the risk of overdose. [5]

Symptoms of antipsychotic overdose

Antipsychotic overdose can lead to a wide range of symptoms including: [6]

  • Extreme sedation
  • Agitation
  • Delirium
  • Hallucinations
  • Coma
  • Tachycardia
  • Mydriasis
  • Flushed Skin
  • Decreased production of sweat
  • Decreasedproduction of saliva
  • Urinary retention
  • Mild hypotension
  • Nausea
  • Vomiting
  • Dystonia (involuntary muscle movements)

It's important to note that the symptoms of antipsychotic overdose can vary widely, and not everyone will experience the same set of symptoms. A person may suffer cardiovascular, neurological, pulmonary, endocrine, dermatologic, or metabolic symptoms relating to overdose. [6] Additionally, other factors such as the presence of other substances in the body can complicate the clinical presentation.

Treatment for antipsychotic overdose

The treatment for antipsychotic overdose involves swift medical intervention to stabilize the individual and address the effects of the overdose. It typically includes:

  1. Assessment and Monitoring: Healthcare professionals assess the individual's vital signs, conduct a physical examination, and gather information about the overdose circumstances.
  2. Supportive Care: Measures are taken to stabilize the person's condition, including providing oxygen, maintaining hydration, and managing blood pressure and heart rate. [1]
  3. Activated Charcoal or Gastric Lavage: If the overdose occurred recently, activated charcoal might be administered to absorb the excess medication. [1] Gastric lavage (stomach pumping) could also be considered to remove the medication.
  4. Medication Reversal: In some cases, antidotes or medications may be used to counteract the effects of the overdose, if available and appropriate.
  5. Symptom Management: Healthcare professionals address specific symptoms such as sedation, abnormal heart rhythm, and respiratory insufficiency.  Patients may require intubation, hyperventilation,or plasma alkalinization. [1]
  6. Monitoring: The individual's vital signs, mental status, and other parameters are continuously monitored to detect any changes and ensure stabilization.
  7. Psychological Support: Individuals who have overdosed might require psychological support, from a counsellor or therapist, to manage any emotional distress or confusion.

The treatment approach depends on factors such as the type and amount of medication ingested, individual health status, and presence of other substances. Many antipsychotic overdoses will result in mild sedation, with patients allowed to leave hospital six hours after the initial poisoning. [1]

However, in serious cases, symptoms need to be managed effectively as quickly as possible. Seeking immediate medical attention is crucial in cases of antipsychotic overdose to prevent serious complications and ensure the person's well-being.

References

    \n
  1. Parsons, M., & Buckley, N. A. (1997). Overdose of Antipsychotic Drugs. CNS Drugs, 7(6), 427–441. Overdose of Antipsychotic Drugs
    2. \n
  2. Trenton, A. J., Currier, G. W., & Zwemer, F. L. (2003). Fatalities Associated with Therapeutic Use and Overdose of Atypical Antipsychotics. CNS Drugs, 17(5), 307–324. Fatalities Associated with Therapeutic Use and Overdose of Atypical Antipsychotics
    3. \n
  3. Berling, I., Buckley, N. A., & Isbister, G. K. (2016). The antipsychotic story: changes in prescriptions and overdose without better safety. British Journal of Clinical Pharmacology, 82(1), 249–254. The antipsychotic story
    4. \n
  4. DynaMed. (n.d.). Www.dynamed.com. dynamed.com
    5. \n
  5. Tay, E., Sotiriou, A., Graham, G. G., Wilhelm, K., Snowden, L., & Day, R. O. (2019). Restarting antidepressant and antipsychotic medication after intentional overdoses: need for evidence-based guidance. Therapeutic Advances in Psychopharmacology, 9, 204512531983688. Restarting antidepressant and antipsychotic medication after intentional overdoses
    6. \n
  6. Rasimas, J. J., & Liebelt, E. L. (2012). Adverse Effects and Toxicity of the Atypical Antipsychotics: What is Important for the Pediatric Emergency Medicine Practitioner. Clinical pediatric emergency medicine, 13(4), 300–310. Adverse Effects and Toxicity of the Atypical Antipsychotics
    7. \n

Medical Content

The Clinical Affairs Team at MentalHealth.com is a dedicated group of medical professionals with diverse and extensive clinical experience. They actively contribute to the development of content, products, and services, and meticulously review all medical material before publication to ensure accuracy and alignment with current research and conversations in mental health. For more information, please visit the Editorial Policy.

About MentalHealth.com

MentalHealth.com helps people understand themselves, build healthier relationships, and access the right care. We bring together mental health education, diagnostics, and care management to support well-being throughout every phase of life.

\"\"

Author

Leila Khurshid, Pharm.D.

Pharm.D., BCPS

Leila Khursid is a medical reviewer with a Doctor of Pharmacy degree and completed a PGY1 Pharmacy Residency from St. Mark's Hospital.

Published
Updated
\"\"

Medical Reviewer

Morgan Blair

MA, LPCC

Morgan Blair is a licensed therapist, writer and medical reviewer, holding a master’s degree in clinical mental health counseling from Northwestern University.

Reviewed

Subject matter expert

\"\"

Leila Khurshid, Pharm.D.

Clinical pharmacy and medication

View experience
\"\"

Related communities

Medications

Explore questions and perspectives about psychiatric medications and the treatment experience.

Explore community
","text":"HomeLibraryMedicationsAntipsychotics and Overdose RisksAntipsychotics and Overdose RisksWritten by Leila Khurshid, Pharm.D.Medically reviewed by Morgan BlairPublished on September 29, 2023 · Updated on September 2, 2025Antipsychotic medications play a key role in treating conditions such as schizophrenia, bipolar disorder, and other psychiatric disorders.However, understanding the potential risks associated with these medications is essential to ensure their safe and effective use. Navigating the realm of medication safety is a paramount concern for individuals managing their mental health and well-being.One significant question that arises is whether it is possible to overdose on antipsychotics?In this article, we will delve into the complexities of antipsychotic overdoses, examining factors that contribute to the risk of overdose, signs and symptoms to be aware of, and how to react during a potential overdose.Key takeawaysAntipsychotic overdose can cause serious cardiovascular and nervous-system complications.Excess doses and combinations with other substances can increase toxicity, with symptoms ranging from sedation to delirium or coma.Suspected overdose requires prompt medical assessment, monitoring, and treatment to stabilize the person.Is it possible to overdose on antipsychotics?It is possible to overdose on antipsychotics and is a matter of vital importance. Antipsychotic medications, like many other types of medications, have a therapeutic range in which they are effective and safe. Taking an excessive dose of antipsychotics can lead to serious health risks and complications.Patients can develop cardiotoxicity, seizures, or coma, requiring an admission to an intensive care unit. [1] These outcomes are associated with severe overdoses, with many antipsychotic overdoses resulting in mild sedation and patients being discharged six hours after the initial poisoning. [1] Nonetheless, people have died due to overdosing on atypical antipsychotics. [2]Atypical antipsychotics, such as clozapine, risperidone, olanzapine, quetiapine, and ziprasidone, were made available for use in the late 1980s. [2] Deaths resulting from atypical antipsychotic overdose are often related to cardiovascular complications, but can also be the result of gastrointestinal, neurological, or endocrine issues. [2]Since the late 1980s, morbidity and mortality from antipsychotic overdose has increased, with a 2016 Australian study showing that these increases occurred despite overall drug overdoses falling. [3] Olanzapine and quetiapine accounted for 78% of these overdoses, whist atypical antipsychotics generally made up most overdoses. [4]How do antipsychotics cause toxicity?Antipsychotics cause toxicity in multiple ways including obstructing potassium and sodium channels in the body, via alpha-1 adrenergic blockade and through anticholinergic effects. [4] Various organs are impacted but the cardiovascular and central nervous system are affected worse than any others. [4]What factors contribute to antipsychotic overdose?Understanding the factors that contribute to antipsychotic overdose is crucial for preventing overdose and promoting safe medication use. Here are some key contributors to antipsychotic overdose:Dose and Medication Strength: Taking a higher dose of antipsychotic medication than prescribed significantly increases the risk of overdose. [2] Additionally, some formulations of antipsychotics may have higher concentrations, making them more potent.Accidental Ingestion: Accidental ingestion can occur when someone, especially children, mistakenly ingests antipsychotic medication that was not stored securely or was mistaken for another medication.Combining with Other Substances: Self-poisoning by mixing antipsychotic medications with alcohol, antidepressants, opioids, and other illicit drugs can potentiate the effects and increase the risk of overdose. [5]Symptoms of antipsychotic overdoseAntipsychotic overdose can lead to a wide range of symptoms including: [6]Extreme sedationAgitationDeliriumHallucinationsComaTachycardiaMydriasisFlushed SkinDecreased production of sweatDecreasedproduction of salivaUrinary retentionMild hypotensionNauseaVomitingDystonia (involuntary muscle movements)It's important to note that the symptoms of antipsychotic overdose can vary widely, and not everyone will experience the same set of symptoms. A person may suffer cardiovascular, neurological, pulmonary, endocrine, dermatologic, or metabolic symptoms relating to overdose. [6] Additionally, other factors such as the presence of other substances in the body can complicate the clinical presentation.Treatment for antipsychotic overdoseThe treatment for antipsychotic overdose involves swift medical intervention to stabilize the individual and address the effects of the overdose. It typically includes:Assessment and Monitoring: Healthcare professionals assess the individual's vital signs, conduct a physical examination, and gather information about the overdose circumstances.Supportive Care: Measures are taken to stabilize the person's condition, including providing oxygen, maintaining hydration, and managing blood pressure and heart rate. [1]Activated Charcoal or Gastric Lavage: If the overdose occurred recently, activated charcoal might be administered to absorb the excess medication. [1] Gastric lavage (stomach pumping) could also be considered to remove the medication.Medication Reversal: In some cases, antidotes or medications may be used to counteract the effects of the overdose, if available and appropriate.Symptom Management: Healthcare professionals address specific symptoms such as sedation, abnormal heart rhythm, and respiratory insufficiency. Patients may require intubation, hyperventilation,or plasma alkalinization. [1]Monitoring: The individual's vital signs, mental status, and other parameters are continuously monitored to detect any changes and ensure stabilization.Psychological Support: Individuals who have overdosed might require psychological support, from a counsellor or therapist, to manage any emotional distress or confusion.The treatment approach depends on factors such as the type and amount of medication ingested, individual health status, and presence of other substances. Many antipsychotic overdoses will result in mild sedation, with patients allowed to leave hospital six hours after the initial poisoning. [1]However, in serious cases, symptoms need to be managed effectively as quickly as possible. Seeking immediate medical attention is crucial in cases of antipsychotic overdose to prevent serious complications and ensure the person's well-being.References Parsons, M., & Buckley, N. A. (1997). Overdose of Antipsychotic Drugs. CNS Drugs, 7(6), 427–441. Overdose of Antipsychotic Drugs Trenton, A. J., Currier, G. W., & Zwemer, F. L. (2003). Fatalities Associated with Therapeutic Use and Overdose of Atypical Antipsychotics. CNS Drugs, 17(5), 307–324. Fatalities Associated with Therapeutic Use and Overdose of Atypical Antipsychotics Berling, I., Buckley, N. A., & Isbister, G. K. (2016). The antipsychotic story: changes in prescriptions and overdose without better safety. British Journal of Clinical Pharmacology, 82(1), 249–254. The antipsychotic story DynaMed. (n.d.). Www.dynamed.com. dynamed.com Tay, E., Sotiriou, A., Graham, G. G., Wilhelm, K., Snowden, L., & Day, R. O. (2019). Restarting antidepressant and antipsychotic medication after intentional overdoses: need for evidence-based guidance. Therapeutic Advances in Psychopharmacology, 9, 204512531983688. Restarting antidepressant and antipsychotic medication after intentional overdoses Rasimas, J. J., & Liebelt, E. L. (2012). Adverse Effects and Toxicity of the Atypical Antipsychotics: What is Important for the Pediatric Emergency Medicine Practitioner. Clinical pediatric emergency medicine, 13(4), 300–310. Adverse Effects and Toxicity of the Atypical Antipsychotics Medical ContentThe Clinical Affairs Team at MentalHealth.com is a dedicated group of medical professionals with diverse and extensive clinical experience. They actively contribute to the development of content, products, and services, and meticulously review all medical material before publication to ensure accuracy and alignment with current research and conversations in mental health. For more information, please visit the Editorial Policy.About MentalHealth.comMentalHealth.com helps people understand themselves, build healthier relationships, and access the right care. We bring together mental health education, diagnostics, and care management to support well-being throughout every phase of life.AuthorLeila Khurshid, Pharm.D.Pharm.D., BCPSLeila Khursid is a medical reviewer with a Doctor of Pharmacy degree and completed a PGY1 Pharmacy Residency from St. Mark's Hospital.PublishedSeptember 29, 2023UpdatedSeptember 2, 2025Medical ReviewerMorgan BlairMA, LPCCMorgan Blair is a licensed therapist, writer and medical reviewer, holding a master’s degree in clinical mental health counseling from Northwestern University.ReviewedSeptember 29, 2023Subject matter expertLeila Khurshid, Pharm.D.Clinical pharmacy and medicationView experienceRelated communitiesMedicationsExplore questions and perspectives about psychiatric medications and the treatment experience.Explore communityTable of contentsChoose a sectionIs it possible to overdose on antipsychotics?How do antipsychotics cause toxicity?What factors contribute to antipsychotic overdose?Symptoms of antipsychotic overdoseTreatment for antipsychotic overdoseView moreSubject matter expertLeila Khurshid, Pharm.D.Clinical pharmacy and medicationView experienceRelated communitiesMedicationsExplore questions and perspectives about psychiatric medications and the treatment experience.Explore community","wordCount":1237},"schema":{"@context":"https://schema.org","@graph":[{"@type":"Organization","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/#organization","name":"MentalHealth.com","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/"},{"@type":"WebSite","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/#website","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/","name":"MentalHealth.com","inLanguage":"en-US","publisher":{"@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/#organization"}},{"@type":"BreadcrumbList","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://mentalhealth-v2.workspace-454808.chatgpt.site/"},{"@type":"ListItem","position":2,"name":"Library","item":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library"},{"@type":"ListItem","position":3,"name":"Medications","item":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/medications"},{"@type":"ListItem","position":4,"name":"Antipsychotics and Overdose Risks","item":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics"}]},{"@type":"ImageObject","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#primaryimage","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/library/editorial-11765.webp","contentUrl":"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/library/editorial-11765.webp","width":1199,"height":800,"encodingFormat":"image/webp","caption":"An older patient speaks with a healthcare professional beside a window."},{"@type":"Person","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/leila-khurshid#person","name":"Leila Khurshid, Pharm.D.","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/leila-khurshid","jobTitle":"Pharm.D., BCPS","image":"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/wordpress/3060.webp","sameAs":["https://www.linkedin.com/in/leila-khurshid-pharmd-bcps/"]},{"@type":"Person","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/morgan-blair#person","name":"Morgan Blair","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/morgan-blair","jobTitle":"MA, LPCC","image":"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/wordpress/3070.jpg","sameAs":["https://www.linkedin.com/in/morgan-blair-5627aa88/"]},{"@type":"Article","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#article","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics","headline":"Antipsychotics and Overdose Risks","description":"Like almost any drug, it's possible to overdose on antipsychotic medications. Therefore, you should never take more than what is prescribed for you.","wordCount":880,"mainEntityOfPage":{"@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#webpage"},"publisher":{"@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/#organization"},"articleSection":"Library","citation":[{"@type":"CreativeWork","name":"Parsons, M., & Buckley, N. A. (1997). Overdose of Antipsychotic Drugs. CNS Drugs, 7(6), 427–441. Overdose of Antipsychotic Drugs","url":"https://doi.org/10.2165/00023210-199707060-00002"},{"@type":"CreativeWork","name":"Trenton, A. J., Currier, G. W., & Zwemer, F. L. (2003). Fatalities Associated with Therapeutic Use and Overdose of Atypical Antipsychotics. CNS Drugs, 17(5), 307–324. Fatalities Associated with Therapeutic Use and Overdose of Atypical Antipsychotics","url":"https://doi.org/10.2165/00023210-200317050-00002"},{"@type":"CreativeWork","name":"Berling, I., Buckley, N. A., & Isbister, G. K. (2016). The antipsychotic story: changes in prescriptions and overdose without better safety. British Journal of Clinical Pharmacology, 82(1), 249–254. The antipsychotic story","url":"https://doi.org/10.1111/bcp.12927"},{"@type":"CreativeWork","name":"DynaMed. (n.d.). Www.dynamed.com. dynamed.com","url":"https://www.dynamed.com/management/antipsychotic-toxicity-emergency-management#GUID-2652D2CC-8469-4C1F-A5C8-07D75B3650D5"},{"@type":"CreativeWork","name":"Tay, E., Sotiriou, A., Graham, G. G., Wilhelm, K., Snowden, L., & Day, R. O. (2019). Restarting antidepressant and antipsychotic medication after intentional overdoses: need for evidence-based guidance. Therapeutic Advances in Psychopharmacology, 9, 204512531983688. Restarting antidepressant and antipsychotic medication after intentional overdoses","url":"https://doi.org/10.1177/2045125319836889"},{"@type":"CreativeWork","name":"Rasimas, J. J., & Liebelt, E. L. (2012). Adverse Effects and Toxicity of the Atypical Antipsychotics: What is Important for the Pediatric Emergency Medicine Practitioner. Clinical pediatric emergency medicine, 13(4), 300–310. Adverse Effects and Toxicity of the Atypical Antipsychotics","url":"https://doi.org/10.1016/j.cpem.2012.09.005"}],"inLanguage":"en-US","datePublished":"2023-09-29T12:20:15Z","dateModified":"2025-09-02T09:14:21Z","author":[{"@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/leila-khurshid#person"}],"image":{"@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#primaryimage"}},{"@type":"MedicalWebPage","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#webpage","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics","name":"Antipsychotics and Overdose Risks","description":"Like almost any drug, it's possible to overdose on antipsychotic medications. Therefore, you should never take more than what is prescribed for you.","inLanguage":"en-US","isPartOf":{"@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/#website"},"breadcrumb":{"@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#breadcrumb"},"mainEntity":{"@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#article"},"relatedLink":["https://mentalhealth-v2.workspace-454808.chatgpt.site/library/antipsychotics","https://mentalhealth-v2.workspace-454808.chatgpt.site/library/are-antipsychotics-addictive","https://mentalhealth-v2.workspace-454808.chatgpt.site/library/long-term-effects-of-antipsychotics","https://mentalhealth-v2.workspace-454808.chatgpt.site/library/clonazepam-uses-dosage-side-effects","https://mentalhealth-v2.workspace-454808.chatgpt.site/library/amphetamines","https://mentalhealth-v2.workspace-454808.chatgpt.site/people/leila-khurshid"],"publisher":{"@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/#organization"},"medicalAudience":{"@type":"MedicalAudience","audienceType":"General public"},"datePublished":"2023-09-29T12:20:15Z","dateModified":"2025-09-02T09:14:21Z","lastReviewed":"2023-09-29","primaryImageOfPage":{"@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#primaryimage"},"image":{"@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#primaryimage"},"reviewedBy":{"@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/morgan-blair#person"}}]},"representations":{"html":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics","json":"https://mentalhealth-v2.workspace-454808.chatgpt.site/data/library/can-you-overdose-on-antipsychotics.json","jsonLd":"https://mentalhealth-v2.workspace-454808.chatgpt.site/data/library/can-you-overdose-on-antipsychotics.ld.json"},"$schema":"https://mentalhealth-v2.workspace-454808.chatgpt.site/data/page.schema.json","images":[{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/wordpress/3060.webp","alt":"","width":22,"height":22},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/wordpress/3070.jpg","alt":"","width":22,"height":22},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/library/editorial-11765.webp","alt":"An older patient speaks with a healthcare professional beside a window.","width":1199,"height":800},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/library/editorial-17234.webp","alt":"","width":48,"height":48}],"sections":[{"id":"key-takeaways","title":"Key takeaways","level":2,"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#key-takeaways"},{"id":"is-it-possible-to-overdose-on-antipsychotics","title":"Is it possible to overdose on antipsychotics?","level":2,"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#is-it-possible-to-overdose-on-antipsychotics"},{"id":"how-do-antipsychotics-cause-toxicity","title":"How do antipsychotics cause toxicity?","level":2,"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#how-do-antipsychotics-cause-toxicity"},{"id":"what-factors-contribute-to-antipsychotic-overdose","title":"What factors contribute to antipsychotic overdose?","level":2,"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#what-factors-contribute-to-antipsychotic-overdose"},{"id":"symptoms-of-antipsychotic-overdose","title":"Symptoms of antipsychotic overdose","level":2,"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#symptoms-of-antipsychotic-overdose"},{"id":"treatment-for-antipsychotic-overdose","title":"Treatment for antipsychotic overdose","level":2,"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#treatment-for-antipsychotic-overdose"},{"id":"references-2","title":"References","level":2,"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#references-2"},{"id":"medical-content","title":"Medical Content","level":2,"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#medical-content"},{"id":"about-mentalhealth-com","title":"About MentalHealth.com","level":2,"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#about-mentalhealth-com"},{"id":"leila-khurshid-pharm-d","title":"Leila Khurshid, Pharm.D.","level":3,"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#leila-khurshid-pharm-d"},{"id":"morgan-blair","title":"Morgan Blair","level":3,"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#morgan-blair"}],"references":[{"number":1,"id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#overdose-antipsychotic-drugs","text":"Parsons, M., & Buckley, N. A. (1997). Overdose of Antipsychotic Drugs. CNS Drugs, 7(6), 427–441. Overdose of Antipsychotic Drugs","links":[{"url":"https://doi.org/10.2165/00023210-199707060-00002","label":"Overdose of Antipsychotic Drugs"}],"url":"https://doi.org/10.2165/00023210-199707060-00002"},{"number":2,"id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#fatalities-associated-therapeutic-use-overdose-atypical-antipsychotics","text":"Trenton, A. J., Currier, G. W., & Zwemer, F. L. (2003). Fatalities Associated with Therapeutic Use and Overdose of Atypical Antipsychotics. CNS Drugs, 17(5), 307–324. Fatalities Associated with Therapeutic Use and Overdose of Atypical Antipsychotics","links":[{"url":"https://doi.org/10.2165/00023210-200317050-00002","label":"Fatalities Associated with Therapeutic Use and Overdose of Atypical Antipsychotics"}],"url":"https://doi.org/10.2165/00023210-200317050-00002"},{"number":3,"id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#antipsychotic-story-changes-prescriptions-overdose-without-better-safety","text":"Berling, I., Buckley, N. A., & Isbister, G. K. (2016). The antipsychotic story: changes in prescriptions and overdose without better safety. British Journal of Clinical Pharmacology, 82(1), 249–254. The antipsychotic story","links":[{"url":"https://doi.org/10.1111/bcp.12927","label":"The antipsychotic story"}],"url":"https://doi.org/10.1111/bcp.12927"},{"number":4,"id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#www-dynamed-com","text":"DynaMed. (n.d.). Www.dynamed.com. dynamed.com","links":[{"url":"https://www.dynamed.com/management/antipsychotic-toxicity-emergency-management#GUID-2652D2CC-8469-4C1F-A5C8-07D75B3650D5","label":"dynamed.com"}],"url":"https://www.dynamed.com/management/antipsychotic-toxicity-emergency-management#GUID-2652D2CC-8469-4C1F-A5C8-07D75B3650D5"},{"number":5,"id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#restarting-antidepressant-antipsychotic-medication-after-intentional-overdoses-need-evid","text":"Tay, E., Sotiriou, A., Graham, G. G., Wilhelm, K., Snowden, L., & Day, R. O. (2019). Restarting antidepressant and antipsychotic medication after intentional overdoses: need for evidence-based guidance. Therapeutic Advances in Psychopharmacology, 9, 204512531983688. Restarting antidepressant and antipsychotic medication after intentional overdoses","links":[{"url":"https://doi.org/10.1177/2045125319836889","label":"Restarting antidepressant and antipsychotic medication after intentional overdoses"}],"url":"https://doi.org/10.1177/2045125319836889"},{"number":6,"id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#adverse-effects-toxicity-atypical-antipsychotics-important-pediatric-emergency-medicine","text":"Rasimas, J. J., & Liebelt, E. L. (2012). Adverse Effects and Toxicity of the Atypical Antipsychotics: What is Important for the Pediatric Emergency Medicine Practitioner. Clinical pediatric emergency medicine, 13(4), 300–310. Adverse Effects and Toxicity of the Atypical Antipsychotics","links":[{"url":"https://doi.org/10.1016/j.cpem.2012.09.005","label":"Adverse Effects and Toxicity of the Atypical Antipsychotics"}],"url":"https://doi.org/10.1016/j.cpem.2012.09.005"}],"relatedReading":[],"links":[{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/","label":"Home"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library","label":"Library"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/medications","label":"Medications"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/leila-khurshid","label":"Leila Khurshid, Pharm.D."},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/morgan-blair","label":"Morgan Blair"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/antipsychotics","label":"Antipsychotic medications"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#overdose-antipsychotic-drugs","label":"[1]"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#overdose-antipsychotic-drugs","label":"[1]"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#fatalities-associated-therapeutic-use-overdose-atypical-antipsychotics","label":"[2]"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#fatalities-associated-therapeutic-use-overdose-atypical-antipsychotics","label":"[2]"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#fatalities-associated-therapeutic-use-overdose-atypical-antipsychotics","label":"[2]"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#antipsychotic-story-changes-prescriptions-overdose-without-better-safety","label":"[3]"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#www-dynamed-com","label":"[4]"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#www-dynamed-com","label":"[4]"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#www-dynamed-com","label":"[4]"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#fatalities-associated-therapeutic-use-overdose-atypical-antipsychotics","label":"[2]"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#restarting-antidepressant-antipsychotic-medication-after-intentional-overdoses-need-evid","label":"[5]"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#adverse-effects-toxicity-atypical-antipsychotics-important-pediatric-emergency-medicine","label":"[6]"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#adverse-effects-toxicity-atypical-antipsychotics-important-pediatric-emergency-medicine","label":"[6]"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#overdose-antipsychotic-drugs","label":"[1]"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#overdose-antipsychotic-drugs","label":"[1]"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#overdose-antipsychotic-drugs","label":"[1]"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#overdose-antipsychotic-drugs","label":"[1]"},{"url":"https://doi.org/10.2165/00023210-199707060-00002","label":"Overdose of Antipsychotic Drugs"},{"url":"https://doi.org/10.2165/00023210-200317050-00002","label":"Fatalities Associated with Therapeutic Use and Overdose of Atypical Antipsychotics"},{"url":"https://doi.org/10.1111/bcp.12927","label":"The antipsychotic story"},{"url":"https://www.dynamed.com/management/antipsychotic-toxicity-emergency-management#GUID-2652D2CC-8469-4C1F-A5C8-07D75B3650D5","label":"dynamed.com"},{"url":"https://doi.org/10.1177/2045125319836889","label":"Restarting antidepressant and antipsychotic medication after intentional overdoses"},{"url":"https://doi.org/10.1016/j.cpem.2012.09.005","label":"Adverse Effects and Toxicity of the Atypical Antipsychotics"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/clinical-affairs","label":"The Clinical Affairs Team"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/publishing/editorial-policy","label":"Editorial Policy"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/leila-khurshid","label":"Leila Khurshid, Pharm.D."},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/morgan-blair","label":"Morgan Blair"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/leila-khurshid","label":"Leila Khurshid, Pharm.D."},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/leila-khurshid","label":"View experience"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/community/medications","label":"Explore community"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#is-it-possible-to-overdose-on-antipsychotics","label":"Is it possible to overdose on antipsychotics?"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#how-do-antipsychotics-cause-toxicity","label":"How do antipsychotics cause toxicity?"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#what-factors-contribute-to-antipsychotic-overdose","label":"What factors contribute to antipsychotic overdose?"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#symptoms-of-antipsychotic-overdose","label":"Symptoms of antipsychotic overdose"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics#treatment-for-antipsychotic-overdose","label":"Treatment for antipsychotic overdose"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/leila-khurshid","label":"Leila Khurshid, Pharm.D."},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/leila-khurshid","label":"View experience"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/community/medications","label":"Explore community"}],"seo":{"title":"Antipsychotics and Overdose Risks | MentalHealth.com","description":"Like almost any drug, it's possible to overdose on antipsychotic medications. Therefore, you should never take more than what is prescribed for you.","canonical":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics","robots":"index,follow","socialImage":{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/social-tiles-20261006-dots/library.png","width":1200,"height":630,"alt":"MentalHealth.com — Library","type":"image/png","sitemapGroup":"library"}},"breadcrumbs":[{"name":"Home","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/"},{"name":"Library","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library"},{"name":"Medications","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/medications"},{"name":"Antipsychotics and Overdose Risks","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/can-you-overdose-on-antipsychotics"}],"subjectMatterExpert":{"name":"Leila Khurshid, Pharm.D.","url":"/people/leila-khurshid","profileId":"2317","topic":"medication","focus":"Clinical pharmacy and medication","selectionBasis":"Documented expertise in the existing published profile","reviewAttribution":false},"keyTakeaways":["Antipsychotic overdose can cause serious cardiovascular and nervous-system complications.","Excess doses and combinations with other substances can increase toxicity, with symptoms ranging from sedation to delirium or coma.","Suspected overdose requires prompt medical assessment, monitoring, and treatment to stabilize the person."],"introduction":{"html":"Antipsychotic medications play a key role in treating conditions such as schizophrenia, bipolar disorder, and other psychiatric disorders.\n\nHowever, understanding the potential risks associated with these medications is essential to ensure their safe and effective use. Navigating the realm of medication safety is a paramount concern for individuals managing their mental health and well-being.\n\nOne significant question that arises is whether it is possible to overdose on antipsychotics?\n\nIn this article, we will delve into the complexities of antipsychotic overdoses, examining factors that contribute to the risk of overdose, signs and symptoms to be aware of, and how to react during a potential overdose.","text":"Antipsychotic medications play a key role in treating conditions such as schizophrenia, bipolar disorder, and other psychiatric disorders. However, understanding the potential risks associated with these medications is essential to ensure their safe and effective use. Navigating the realm of medication safety is a paramount concern for individuals managing their mental health and well-being. One significant question that arises is whether it is possible to overdose on antipsychotics? In this article, we will delve into the complexities of antipsychotic overdoses, examining factors that contribute to the risk of overdose, signs and symptoms to be aware of, and how to react during a potential overdose.","sourceField":"hero"},"navigation":[{"label":"Is it possible to overdose on antipsychotics?","href":"#is-it-possible-to-overdose-on-antipsychotics","heading":"Is it possible to overdose on antipsychotics?"},{"label":"How do antipsychotics cause toxicity?","href":"#how-do-antipsychotics-cause-toxicity","heading":"How do antipsychotics cause toxicity?"},{"label":"What factors contribute to antipsychotic overdose?","href":"#what-factors-contribute-to-antipsychotic-overdose","heading":"What factors contribute to antipsychotic overdose?"},{"label":"Symptoms of antipsychotic overdose","href":"#symptoms-of-antipsychotic-overdose","heading":"Symptoms of antipsychotic overdose"},{"label":"Treatment for antipsychotic overdose","href":"#treatment-for-antipsychotic-overdose","heading":"Treatment for antipsychotic overdose"}],"relatedCommunity":{"community":"/community/medications","basis":"topic match"},"referencePresentation":"Numbered author–date bibliography with linked source documents; n.d. denotes unavailable publication date.","collections":[]}