{"formatVersion":"1.1","id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/buspirone-uses-dosage-side-effects","path":"/library/buspirone-uses-dosage-side-effects","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/buspirone-uses-dosage-side-effects","title":"Buspirone (Buspar)","family":"Library detail","description":"Buspirone (BuSpar) is an anti-anxiety drug that treats various anxiety disorders. Learn more about how it is used, interactions, and more.","language":"en-US","access":{"audience":"custom-shared-preview","indexable":true},"provenance":{"sourceUrl":"https://www.mentalhealth.com/library/buspirone-uses-dosage-side-effects","wordpressId":"221","contentCompleteness":"complete","dateScope":"original-source"},"authors":[{"@type":"Person","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/emily-doe#person","name":"Emily Doe","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/emily-doe"}],"reviewer":{"@type":"Person","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/leila-khurshid#person","name":"Leila Khurshid, Pharm.D.","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/leila-khurshid"},"dates":{"datePublished":"2022-10-10T20:00:00Z","dateModified":"2026-05-17T18:52:43Z","lastReviewed":"2022-10-11"},"content":{"html":"<nav class=\"breadcrumbs\" aria-label=\"Breadcrumb\"><ol><li><a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/\">Home</a></li><li><a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/library\">Library</a></li><li><a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/medications\">Medications</a></li><li><span aria-current=\"page\">Buspirone (Buspar)</span></li></ol></nav><div class=\"article-page article-standard\" data-library-standard><div class=\"article-main-grid\"><header class=\"article-heading\"><h1>Buspirone (Buspar)</h1><p class=\"article-inline-credits\"><span>Written by <a class=\"article-credit-person\" href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/emily-doe\"><img src=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/wordpress/3062.jpg\" alt=\"\" width=\"22\" height=\"22\" loading=\"lazy\">Emily Doe</a></span><span>Medically reviewed by <a class=\"article-credit-person\" href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/leila-khurshid\"><img src=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/wordpress/3060.webp\" alt=\"\" width=\"22\" height=\"22\" loading=\"lazy\">Leila Khurshid, Pharm.D.</a></span></p><div class=\"article-dates\"><span>Published on <time datetime=\"2022-10-10T20:00:00Z\">October 10, 2022</time></span><span aria-hidden=\"true\"> · </span><span>Updated on <time datetime=\"2026-05-17T18:52:43Z\">May 17, 2026</time></span></div></header><div class=\"article-jumpbar\"></div><div class=\"article-layout\"><div class=\"article-reading\"><article class=\"prose\" id=\"article-content\"><div class=\"article-intro\" data-source-field=\"hero\"><p>Buspirone, known as BuSpar, is an <a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/anxiolytics\" class=\"article-inline-link\">anxiolytic medication</a> used to treat generalized anxiety disorder and short-term anxiety symptoms. This medication should only be taken under the supervision of a medical doctor, as adverse reactions with certain foods and other medications may occur.</p></div><figure class=\"article-feature\"><img src=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/library/editorial-11118.webp\" alt=\"An adult sits with hands clasped during a conversation.\" width=\"1200\" height=\"633\" loading=\"eager\" decoding=\"async\"></figure><section class=\"article-takeaways\" aria-labelledby=\"key-takeaways\"><h2 id=\"key-takeaways\">Key takeaways</h2><ul><li>Buspirone is an anti-anxiety medication primarily used for generalized anxiety disorder under medical supervision.</li><li>Medical conditions, alcohol, and other medications can affect its safety and increase adverse reactions.</li><li>Buspirone has a lower risk of misuse and physical dependence than benzodiazepines such as Xanax.</li></ul></section><h2 id=\"brand-names\">Buspirone brand names</h2><p>\nBuspirone is most known as BuSpar. However, this brand name has since been discontinued <sup>[5]</sup>. As a result, this medication is now only available in generic form.\n</p><h2 id=\"uses\">What is buspirone prescribed for?</h2><p>\nBuspirone is approved by the U.S. Food and Drug Administration (FDA) to treat generalized anxiety disorder and short-term symptoms associated with other anxiety disorders.\n</p><p>Buspirone is not an effective treatment option for social anxiety disorder. Studies have shown the higher dosages needed for effectiveness with social anxiety symptoms put patients more at risk of experiencing adverse side effects <sup>[7]</sup>.</p><p>Buspirone may be a viable treatment option for those who have experienced adverse side effects from a selective serotonin reuptake inhibitor (SSRI), such as sexual dysfunction, or as an add-on to an SSRI treatment <sup>[1]</sup>. In addition, buspirone is effective for those with mild depression symptoms comorbid with anxiety.</p><p>\nOff-label uses for buspirone include <sup>[6]</sup>:\n</p><ul>\n    <li>Mild depression</li>\n    <li>Post-traumatic stress disorder</li>\n    <li>Bruxism</li>\n    <li>Tardive dyskinesia</li>\n    <li>Pediatric anxiety disorders</li>\n</ul><p>\nOff-label use of medication means that the Food and Drug Administration (FDA) has not approved the medication for treating a particular condition.However, studies support the medication’s use for a specific condition.\n</p><h2 id=\"action\">How does buspirone work?</h2><p>\nThe exact mechanisms behind buspirone's impact on anxiety symptoms are still not entirely understood. However, experts generally believe that the therapeutic results are caused by increased action at serotonin receptors in the brain <sup>[1]</sup>.\n</p><h2 id=\"dosage\">How is buspirone usually taken?</h2><p>\nBuspirone tablets are taken orally in a variety of available dosages. Some tablets are pre-scored to make dividing them in half easy.\n</p><p>Buspirone is only available by prescription and should only be used as prescribed by the doctor. Buspirone is often prescribed twice a day.</p><p>It is recommended that the dosage be slowly increased by 5 mg every 2-3 days until achieving the desired clinical outcome. The typical therapeutic range is between 20-30mg per day <sup>[8]</sup>.</p><p>A missed dose should be taken as soon as possible unless it is nearly time for the next dose. Always ask your healthcare provider if you are unsure whether to take your medication and never double up.</p><p>\nPeople taking this medication should be consistent in whether they take it with food or on an empty stomach <sup>[8]</sup>.\n</p><h2 id=\"half-life\">How long does buspirone stay in your system?</h2><p>\nBuspirone is fast acting and is typically metabolized within 24-48 hours of the last dose.\n</p><h2 id=\"side-effects\">Buspirone side effects</h2><p>\nBuspirone is considered a safe medication. Most people experience minimal side effects or side effects that diminish quickly.\n</p><p>Dizziness is one of the most reported side effects of buspirone.</p><p>\nOther buspirone side effects include <sup>[8]</sup>:\n</p><ul>\n    <li>Abnormal dreams</li>\n    <li>Poor muscle control (ataxia)</li>\n    <li>Confusion</li>\n    <li>Drowsiness</li>\n    <li>Excitability/nervousness</li>\n    <li>Headache</li>\n    <li>Irritability, anger outbursts</li>\n    <li>Numbness</li>\n    <li>\"Pins and needles\" (paresthesia)</li>\n    <li>Blurred vision</li>\n    <li>Ringing in the ears (tinnitus)</li>\n    <li>Nasal congestion</li>\n    <li>Skin rash</li>\n    <li>Diarrhea, nausea, sore throat</li>\n    <li>Muscle pain, tremors, weakness</li>\n    <li>Changes in liver enzymes</li>\n</ul><p>\nRare side effects from buspirone may occur. These include <sup>[8]</sup>:\n</p><ul>\n    <li>Sleepwalking</li>\n    <li>Akathisia (inability to remain still)</li>\n    <li>Cardiac events</li>\n</ul><p>\nDiscuss any side effects with your healthcare provider, as they may indicate that the prescribed dose is too high and titrating the dose down may alleviate side effects.\n</p><h2 id=\"precautions\">Buspirone precautions</h2><p>\nCertain medications can cause adverse drug interactions when taken with buspirone. It is important to speak with the doctor about any other medications you may be taking before taking this medication.\n</p><p>People with certain medical conditions may not be suitable for treatment with buspirone. These conditions should be screened for to prevent adverse reactions to the drug.</p><p>\nBuspirone may not be suitable for those with these pre-existing conditions including <sup>[8]</sup>:\n</p><ul>\n    <li>Kidney diseases</li>\n    <li>Liver diseases</li>\n    <li>Cardiovascular diseases</li>\n    <li>Diabetes</li>\n</ul><p>\nConsuming alcohol while taking buspirone can lead to complications of increased dizziness, drowsiness, and poor coordination <sup>[1]</sup>. Patients who regularly consume alcohol or other substances should discuss this with their doctor before taking buspirone.\nThere have not been enough studies into the effects of buspirone on pregnancy and breastfeeding to determine the safety of its use for pregnant or breastfeeding women.\n</p><h2 id=\"interactions\">Buspirone interactions</h2><p>\nMonoamine oxidase inhibitors (MAOIs), a class of antidepressant medications, can cause high blood pressure when used with buspirone. Buspirone should not be used within 14 days of stopping an MAOI medication <sup>[1]</sup>.\n</p><p>Foods to avoid while taking buspirone include alcohol and grapefruit juice. Alcohol may intensify the effects of buspirone. Consuming large amounts of grapefruit or grapefruit juice may increase the levels of buspirone in the body <sup>[2]</sup>.</p><p>Taking medications affecting liver enzymes with buspirone should be avoided as this may lead to increased side effects. They may also reduce the efficacy of buspirone <sup>[1]</sup>.</p><p>\nAdditionally, these medications are linked to adverse reactions <sup>[4]</sup>:\n</p><h3 id=\"psychotropics\">Psychotropics</h3><ul>\n    <li>Abilify</li>\n    <li>Adderall</li>\n    <li>Cymbalta</li>\n    <li>Lamictal</li>\n    <li>Lexapro</li>\n    <li>Lyrica</li>\n    <li>Prozac</li>\n    <li>Seroquel</li>\n    <li>Vyvanse</li>\n    <li>Wellbutrin XL</li>\n    <li>Xanax</li>\n    <li>Zoloft</li>\n</ul><h3 id=\"blood-pressure-medications\">Blood pressure medications</h3><ul>\n    <li>Metoprolol Succinate ER</li>\n</ul><h3 id=\"allergy-medications\">Allergy medications</h3><ul>\n    <li>Benadryl</li>\n    <li>Zyrtec</li>\n</ul><h3 id=\"vitamins-supplements-and-over-the-counter-medications\">Vitamins, supplements, and over-the-counter medications</h3><ul>\n    <li>Fish Oil</li>\n    <li>Vitamin B12</li>\n    <li>Vitamin C</li>\n    <li>Vitamin D3</li>\n    <li>Tylenol</li>\n</ul><h2 id=\"storage\">Buspirone storage</h2><p>\nBuspirone should be stored in a dry location at room temperature, away from direct light or heat sources <sup>[3]</sup>.\n</p><p>Discard any unused medication when it is no longer needed or expired. For example, avoid flushing tablets down the toilet. Instead, speak with a medical professional regarding the best way to dispose of unneeded medication.</p><p>\nAs with all prescription medications, buspirone should be stored out of the reach of children and teenagers to prevent drug misuse.\n</p><h2 id=\"overdose\">What to do if you overdose on buspirone</h2><p>\nThe risk of severe outcomes from solely buspirone overdose is low. Cases with severe overdose outcomes are associated with two or more substances in addition to buspirone.\nSymptoms of buspirone overdose include <sup>[8]</sup>:\n</p><ul>\n    <li>Gastrointestinal upset: nausea, vomiting</li>\n    <li>Cognitive changes: drowsiness, dizziness, confusion</li>\n    <li>Pupil constriction</li>\n</ul><p>\nDespite the low risk of a fatal outcome, buspirone in high dosages can cause respiratory and cardiac events. In case of an overdose, call the Poison Help line at 1-800-222-1222 and seek immediate emergency medical care.\n</p><h2 id=\"faq\">Frequently asked questions about buspirone</h2><h3 id=\"buspirone-vs-xanax-which-is-more-effective-buspirone-and-xanax-are-both-used-to-treat-anxiety-disorders-buspirone-is-most-effective-at-treating-symptoms-associated-with-generalized-anxiety-disorder-with-less-effective-results-found-for-patients-with-panic-disorder-or-social-anxiety-disorder-xanax-may-be-a-more-effective-treatment-for-these-disorders-due-to-its-immediate-effects-when-taken-xanax-has-a-higher-risk-of-misuse-and-physical-dependence-compared-to-buspirone-therefore-a-physician-should-closely-monitor-xanax-use\">Buspirone vs. Xanax: Which is more effective?</h3><p>\nBuspirone and Xanax are both used to treat anxiety disorders. Buspirone is most effective at treating symptoms associated with generalized anxiety disorder, with less effective results found for patients with panic disorder or social anxiety disorder. Xanax may be a more effective treatment for these disorders due to its immediate effects when taken.\nXanax has a higher risk of misuse and physical dependence compared to buspirone. Therefore, a physician should closely monitor Xanax use.\n</p><h3 id=\"is-buspirone-addictive-the-risk-of-buspirone-being-misused-or-causing-physical-dependence-is-low-it-is-important-to-speak-with-a-medical-provider-if-concerned-about-buspirone-misuse-by-taking-more-than-prescribed-or-using-it-in-conjunction-with-other-substances\">Is buspirone addictive?</h3><p>\nThe risk of buspirone being misused or causing physical dependence is low. It is important to speak with a medical provider if concerned about buspirone misuse by taking more than prescribed or using it in conjunction with other substances.\n</p><p>The risk of misuse is higher when using buspirone in conjunction with other substances, such as alcohol or benzodiazepines. Doing so can lead to serious medical events.</p></article><div class=\"article-endmatter\"><section class=\"article-sources\" id=\"references\" data-source-references=\"\" data-reference-list=\"\" data-reference-style=\"author-date-numbered\"><h2 id=\"references-2\">References</h2><ol>\n    <li id=\"dailymed-buspirone-buspirone-hydrochloride-tablet\" data-reference-number=\"1\"><em>DailyMed - BUSPIRONE- buspirone hydrochloride tablet</em>. (n.d.). Dailymed.nlm.nih.gov. Retrieved November 25, 2022, from <a href=\"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f3bc8ede-13a3-4119-a47a-8234c80bbc05\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">DailyMed</a></li>\n</ol>\n<ol start=\"2\">\n    <li id=\"buspar\" data-reference-number=\"2\">Bristol-Myers Squibb Company. (2010, November). BuSpar®. Retrieved October 17, 2022, from <a href=\"https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/018731s051lbl.pdf\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">U.S. Food and Drug Administration</a></li>\n</ol>\n<ol start=\"3\">\n    <li id=\"buspirone-oral-route\" data-reference-number=\"3\"><em>Buspirone (Oral Route)</em>. (2022, July 18). Retrieved October 19, 2022, from <a href=\"https://www.mayoclinic.org/drugs-supplements/buspirone-oral-route/description/drg-20062457\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">Mayo Clinic</a></li>\n</ol>\n<ol start=\"4\">\n    <li id=\"buspirone-interactions\" data-reference-number=\"4\"><em>Buspirone Interactions</em>. (n.d.). Drugs.com. Retrieved October 19, 2022, from <a href=\"https://www.drugs.com/drug-interactions/buspirone.html\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">Drugs.com</a></li>\n</ol>\n<ol start=\"5\">\n    <li id=\"buspirone-medlineplus-drug-information\" data-reference-number=\"5\"><em>Buspirone: MedlinePlus Drug Information</em>. (n.d.). Retrieved October 19, 2022, from <a href=\"https://medlineplus.gov/druginfo/meds/a688005.html\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">MedlinePlus</a></li>\n</ol>\n<ol start=\"6\">\n    <li id=\"livertox-clinical-research-information-drug-induced-liver-injury-internet\" data-reference-number=\"6\">LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. <em>Buspirone</em>. [Updated 2017 Sep 11]. Available from: <a href=\"https://www.ncbi.nlm.nih.gov/books/NBK547966/\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">National Library of Medicine</a></li>\n</ol>\n<ol start=\"7\">\n    <li id=\"buspirone-social-phobia\" data-reference-number=\"7\">Schneier, F. R., Saoud, J. B., Campeas, R., Fallon, B. A., Hollander, E., Coplan, J., &amp; Liebowitz, M. R. (1993). Buspirone in social phobia. <em>Journal of Clinical Psychopharmacology, 13</em>(4), 251–256. <a href=\"https://doi.org/10.1097/00004714-199308000-00004\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">Buspirone in social phobia</a></li>\n</ol>\n<ol start=\"8\">\n    <li id=\"treasure-island-fl-statpearls-publishing-2022-jan\" data-reference-number=\"8\">Wilson TK, Tripp J. <em>Buspirone</em>. [Updated 2022 Sep 2]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: <a href=\"https://www.ncbi.nlm.nih.gov/books/NBK531477/\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">National Library of Medicine</a></li>\n</ol></section><section class=\"article-medical article-panel\"><h2 id=\"medical-content\">Medical Content</h2><p><a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/clinical-affairs\">The Clinical Affairs Team</a> at MentalHealth.com is a dedicated group of medical professionals with diverse and extensive clinical experience. They actively contribute to the development of content, products, and services, and meticulously review all medical material before publication to ensure accuracy and alignment with current research and conversations in mental health. For more information, please visit the <a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/publishing/editorial-policy\">Editorial Policy</a>.</p></section><section class=\"article-about article-panel\"><h2 id=\"about-mentalhealth-com\">About MentalHealth.com</h2><p>MentalHealth.com helps people understand themselves, build healthier relationships, and access the right care. We bring together mental health education, diagnostics, and care management to support well-being throughout every phase of life.</p><div class=\"article-contributors\"><section class=\"article-bio\"><img src=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/wordpress/3062.jpg\" alt=\"\" width=\"64\" height=\"64\" loading=\"lazy\"><div><p class=\"article-bio-role\">Author</p><h3 id=\"emily-doe\"><a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/emily-doe\">Emily Doe</a></h3><p class=\"article-bio-credentials\">Writer</p><p>Emily Doe is a medical writer with 8+ years of experience, holding a Bachelor of Arts (B.A.) degree in English from the University of Leeds.</p><dl><div><dt>Published</dt><dd><time datetime=\"2022-10-10T20:00:00Z\">October 10, 2022</time></dd></div><div><dt>Updated</dt><dd><time datetime=\"2026-05-17T18:52:43Z\">May 17, 2026</time></dd></div></dl></div></section><section class=\"article-bio\"><img src=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/wordpress/3060.webp\" alt=\"\" width=\"64\" height=\"64\" loading=\"lazy\"><div><p class=\"article-bio-role\">Medical Reviewer</p><h3 id=\"leila-khurshid-pharm-d\"><a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/leila-khurshid\">Leila Khurshid, Pharm.D.</a></h3><p class=\"article-bio-credentials\">Pharm.D., BCPS</p><p>Leila Khursid is a medical reviewer with a Doctor of Pharmacy degree and completed a PGY1 Pharmacy Residency from St. Mark's Hospital.</p><dl><div><dt>Reviewed</dt><dd><time datetime=\"2022-10-11\">October 11, 2022</time></dd></div></dl></div></section></div></section><section class=\"article-expert article-expert-mobile\" aria-label=\"Subject matter expert\" data-expert-kind=\"related\"><p class=\"article-bio-role\">Subject matter expert</p><div class=\"article-expert-identity\"><img src=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/wordpress/3060.webp\" alt=\"\" width=\"64\" height=\"64\" loading=\"lazy\"><h2><a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/leila-khurshid\">Leila Khurshid, Pharm.D.</a></h2></div><p class=\"article-expert-focus\">Clinical pharmacy and medication</p><a class=\"profile-experience-link experience-button\" href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/leila-khurshid\">View experience</a></section><section class=\"article-topic-community article-topic-community-mobile\" aria-label=\"Related communities\"><img class=\"topic-community-banner\" src=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/library/editorial-17234.webp\" alt=\"\" width=\"48\" height=\"48\" loading=\"lazy\"><p class=\"topic-community-label\">Related communities</p><h2>Medications</h2><p>Explore questions and perspectives about psychiatric medications and the treatment experience.</p><a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/community/medications\">Explore community</a></section></div></div><aside class=\"article-sidebar\" tabindex=\"0\" data-bounded-rail=\"\" aria-label=\"Article navigation and related information\"><details class=\"article-contents\" open data-section-preview=\"3\" data-expanded=\"false\" data-scrolled-past=\"false\"><summary><strong>Table of contents</strong><span aria-hidden=\"true\"></span><small data-current-section=\"\">Choose a section</small></summary><nav aria-label=\"Article contents\"><ol id=\"article-section-list\"><li><a href=\"#brand-names\" title=\"Buspirone brand names\" aria-label=\"Buspirone brand names\">Buspirone brand names</a></li><li><a href=\"#uses\" title=\"What is buspirone prescribed for?\" aria-label=\"What is buspirone prescribed for?\">What is buspirone prescribed for?</a></li><li><a href=\"#action\" title=\"How does buspirone work?\" aria-label=\"How does buspirone work?\">How does buspirone work?</a></li><li><a href=\"#dosage\" title=\"How is buspirone usually taken?\" aria-label=\"How is buspirone usually taken?\">How is buspirone usually taken?</a></li><li><a href=\"#half-life\" title=\"How long does buspirone stay in your system?\" aria-label=\"How long does buspirone stay in your system?\">How long does buspirone stay in your system?</a></li><li><a href=\"#side-effects\" title=\"Buspirone side effects\" aria-label=\"Buspirone side effects\">Buspirone side effects</a></li><li><a href=\"#precautions\" title=\"Buspirone precautions\" aria-label=\"Buspirone precautions\">Buspirone precautions</a></li><li><a href=\"#interactions\" title=\"Buspirone interactions\" aria-label=\"Buspirone interactions\">Buspirone interactions</a></li><li><a href=\"#storage\" title=\"Buspirone storage\" aria-label=\"Buspirone storage\">Buspirone storage</a></li><li><a href=\"#overdose\" title=\"What to do if you overdose on buspirone\" aria-label=\"What to do if you overdose on buspirone\">What to do if you overdose on buspirone</a></li><li><a href=\"#faq\" title=\"Frequently asked questions about buspirone\" aria-label=\"Frequently asked questions about buspirone\">Frequently asked questions about buspirone</a></li></ol><button type=\"button\" class=\"article-sections-toggle\" data-sections-toggle aria-controls=\"article-section-list\" aria-expanded=\"false\">View more</button></nav></details><section class=\"article-expert\" aria-label=\"Subject matter expert\" data-expert-kind=\"related\"><p class=\"article-bio-role\">Subject matter expert</p><div class=\"article-expert-identity\"><img src=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/wordpress/3060.webp\" alt=\"\" width=\"64\" height=\"64\" loading=\"lazy\"><h2><a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/leila-khurshid\">Leila Khurshid, Pharm.D.</a></h2></div><p class=\"article-expert-focus\">Clinical pharmacy and medication</p><a class=\"profile-experience-link experience-button\" href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/leila-khurshid\">View experience</a></section><section class=\"article-topic-community\" aria-label=\"Related communities\"><img class=\"topic-community-banner\" src=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/library/editorial-17234.webp\" alt=\"\" width=\"48\" height=\"48\" loading=\"lazy\"><p class=\"topic-community-label\">Related communities</p><h2>Medications</h2><p>Explore questions and perspectives about psychiatric medications and the treatment experience.</p><a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/community/medications\">Explore community</a></section></aside></div></div></div>","text":"HomeLibraryMedicationsBuspirone (Buspar)Buspirone (Buspar)Written by Emily DoeMedically reviewed by Leila Khurshid, Pharm.D.Published on October 10, 2022 · Updated on May 17, 2026Buspirone, known as BuSpar, is an anxiolytic medication used to treat generalized anxiety disorder and short-term anxiety symptoms. This medication should only be taken under the supervision of a medical doctor, as adverse reactions with certain foods and other medications may occur.Key takeawaysBuspirone is an anti-anxiety medication primarily used for generalized anxiety disorder under medical supervision.Medical conditions, alcohol, and other medications can affect its safety and increase adverse reactions.Buspirone has a lower risk of misuse and physical dependence than benzodiazepines such as Xanax.Buspirone brand names Buspirone is most known as BuSpar. However, this brand name has since been discontinued [5]. As a result, this medication is now only available in generic form. What is buspirone prescribed for? Buspirone is approved by the U.S. Food and Drug Administration (FDA) to treat generalized anxiety disorder and short-term symptoms associated with other anxiety disorders. Buspirone is not an effective treatment option for social anxiety disorder. Studies have shown the higher dosages needed for effectiveness with social anxiety symptoms put patients more at risk of experiencing adverse side effects [7].Buspirone may be a viable treatment option for those who have experienced adverse side effects from a selective serotonin reuptake inhibitor (SSRI), such as sexual dysfunction, or as an add-on to an SSRI treatment [1]. In addition, buspirone is effective for those with mild depression symptoms comorbid with anxiety. Off-label uses for buspirone include [6]: Mild depression Post-traumatic stress disorder Bruxism Tardive dyskinesia Pediatric anxiety disorders Off-label use of medication means that the Food and Drug Administration (FDA) has not approved the medication for treating a particular condition.However, studies support the medication’s use for a specific condition. How does buspirone work? The exact mechanisms behind buspirone's impact on anxiety symptoms are still not entirely understood. However, experts generally believe that the therapeutic results are caused by increased action at serotonin receptors in the brain [1]. How is buspirone usually taken? Buspirone tablets are taken orally in a variety of available dosages. Some tablets are pre-scored to make dividing them in half easy. Buspirone is only available by prescription and should only be used as prescribed by the doctor. Buspirone is often prescribed twice a day.It is recommended that the dosage be slowly increased by 5 mg every 2-3 days until achieving the desired clinical outcome. The typical therapeutic range is between 20-30mg per day [8].A missed dose should be taken as soon as possible unless it is nearly time for the next dose. Always ask your healthcare provider if you are unsure whether to take your medication and never double up. People taking this medication should be consistent in whether they take it with food or on an empty stomach [8]. How long does buspirone stay in your system? Buspirone is fast acting and is typically metabolized within 24-48 hours of the last dose. Buspirone side effects Buspirone is considered a safe medication. Most people experience minimal side effects or side effects that diminish quickly. Dizziness is one of the most reported side effects of buspirone. Other buspirone side effects include [8]: Abnormal dreams Poor muscle control (ataxia) Confusion Drowsiness Excitability/nervousness Headache Irritability, anger outbursts Numbness \"Pins and needles\" (paresthesia) Blurred vision Ringing in the ears (tinnitus) Nasal congestion Skin rash Diarrhea, nausea, sore throat Muscle pain, tremors, weakness Changes in liver enzymes Rare side effects from buspirone may occur. These include [8]: Sleepwalking Akathisia (inability to remain still) Cardiac events Discuss any side effects with your healthcare provider, as they may indicate that the prescribed dose is too high and titrating the dose down may alleviate side effects. Buspirone precautions Certain medications can cause adverse drug interactions when taken with buspirone. It is important to speak with the doctor about any other medications you may be taking before taking this medication. People with certain medical conditions may not be suitable for treatment with buspirone. These conditions should be screened for to prevent adverse reactions to the drug. Buspirone may not be suitable for those with these pre-existing conditions including [8]: Kidney diseases Liver diseases Cardiovascular diseases Diabetes Consuming alcohol while taking buspirone can lead to complications of increased dizziness, drowsiness, and poor coordination [1]. Patients who regularly consume alcohol or other substances should discuss this with their doctor before taking buspirone. There have not been enough studies into the effects of buspirone on pregnancy and breastfeeding to determine the safety of its use for pregnant or breastfeeding women. Buspirone interactions Monoamine oxidase inhibitors (MAOIs), a class of antidepressant medications, can cause high blood pressure when used with buspirone. Buspirone should not be used within 14 days of stopping an MAOI medication [1]. Foods to avoid while taking buspirone include alcohol and grapefruit juice. Alcohol may intensify the effects of buspirone. Consuming large amounts of grapefruit or grapefruit juice may increase the levels of buspirone in the body [2].Taking medications affecting liver enzymes with buspirone should be avoided as this may lead to increased side effects. They may also reduce the efficacy of buspirone [1]. Additionally, these medications are linked to adverse reactions [4]: Psychotropics Abilify Adderall Cymbalta Lamictal Lexapro Lyrica Prozac Seroquel Vyvanse Wellbutrin XL Xanax Zoloft Blood pressure medications Metoprolol Succinate ER Allergy medications Benadryl Zyrtec Vitamins, supplements, and over-the-counter medications Fish Oil Vitamin B12 Vitamin C Vitamin D3 Tylenol Buspirone storage Buspirone should be stored in a dry location at room temperature, away from direct light or heat sources [3]. Discard any unused medication when it is no longer needed or expired. For example, avoid flushing tablets down the toilet. Instead, speak with a medical professional regarding the best way to dispose of unneeded medication. As with all prescription medications, buspirone should be stored out of the reach of children and teenagers to prevent drug misuse. What to do if you overdose on buspirone The risk of severe outcomes from solely buspirone overdose is low. Cases with severe overdose outcomes are associated with two or more substances in addition to buspirone. Symptoms of buspirone overdose include [8]: Gastrointestinal upset: nausea, vomiting Cognitive changes: drowsiness, dizziness, confusion Pupil constriction Despite the low risk of a fatal outcome, buspirone in high dosages can cause respiratory and cardiac events. In case of an overdose, call the Poison Help line at 1-800-222-1222 and seek immediate emergency medical care. Frequently asked questions about buspironeBuspirone vs. Xanax: Which is more effective? Buspirone and Xanax are both used to treat anxiety disorders. Buspirone is most effective at treating symptoms associated with generalized anxiety disorder, with less effective results found for patients with panic disorder or social anxiety disorder. Xanax may be a more effective treatment for these disorders due to its immediate effects when taken. Xanax has a higher risk of misuse and physical dependence compared to buspirone. Therefore, a physician should closely monitor Xanax use. Is buspirone addictive? The risk of buspirone being misused or causing physical dependence is low. It is important to speak with a medical provider if concerned about buspirone misuse by taking more than prescribed or using it in conjunction with other substances. The risk of misuse is higher when using buspirone in conjunction with other substances, such as alcohol or benzodiazepines. Doing so can lead to serious medical events.References DailyMed - BUSPIRONE- buspirone hydrochloride tablet. (n.d.). Dailymed.nlm.nih.gov. Retrieved November 25, 2022, from DailyMed Bristol-Myers Squibb Company. (2010, November). BuSpar®. Retrieved October 17, 2022, from U.S. Food and Drug Administration Buspirone (Oral Route). (2022, July 18). Retrieved October 19, 2022, from Mayo Clinic Buspirone Interactions. (n.d.). Drugs.com. Retrieved October 19, 2022, from Drugs.com Buspirone: MedlinePlus Drug Information. (n.d.). Retrieved October 19, 2022, from MedlinePlus LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Buspirone. [Updated 2017 Sep 11]. Available from: National Library of Medicine Schneier, F. R., Saoud, J. B., Campeas, R., Fallon, B. A., Hollander, E., Coplan, J., & Liebowitz, M. R. (1993). Buspirone in social phobia. Journal of Clinical Psychopharmacology, 13(4), 251–256. Buspirone in social phobia Wilson TK, Tripp J. Buspirone. [Updated 2022 Sep 2]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: National Library of Medicine Medical ContentThe Clinical Affairs Team at MentalHealth.com is a dedicated group of medical professionals with diverse and extensive clinical experience. They actively contribute to the development of content, products, and services, and meticulously review all medical material before publication to ensure accuracy and alignment with current research and conversations in mental health. For more information, please visit the Editorial Policy.About MentalHealth.comMentalHealth.com helps people understand themselves, build healthier relationships, and access the right care. We bring together mental health education, diagnostics, and care management to support well-being throughout every phase of life.AuthorEmily DoeWriterEmily Doe is a medical writer with 8+ years of experience, holding a Bachelor of Arts (B.A.) degree in English from the University of Leeds.PublishedOctober 10, 2022UpdatedMay 17, 2026Medical ReviewerLeila Khurshid, Pharm.D.Pharm.D., BCPSLeila Khursid is a medical reviewer with a Doctor of Pharmacy degree and completed a PGY1 Pharmacy Residency from St. Mark's Hospital.ReviewedOctober 11, 2022Subject matter expertLeila Khurshid, Pharm.D.Clinical pharmacy and medicationView experienceRelated communitiesMedicationsExplore questions and perspectives about psychiatric medications and the treatment experience.Explore communityTable of contentsChoose a sectionBuspirone brand namesWhat is buspirone prescribed for?How does buspirone work?How is buspirone usually taken?How long does buspirone stay in your system?Buspirone side effectsBuspirone precautionsBuspirone interactionsBuspirone storageWhat to do if you overdose on buspironeFrequently asked questions about buspironeView moreSubject matter expertLeila Khurshid, Pharm.D.Clinical pharmacy and medicationView experienceRelated communitiesMedicationsExplore questions and perspectives about psychiatric medications and the treatment experience.Explore community","wordCount":1600},"schema":{"@context":"https://schema.org","@graph":[{"@type":"Organization","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/#organization","name":"MentalHealth.com","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/"},{"@type":"WebSite","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/#website","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/","name":"MentalHealth.com","inLanguage":"en-US","publisher":{"@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/#organization"}},{"@type":"BreadcrumbList","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/buspirone-uses-dosage-side-effects#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://mentalhealth-v2.workspace-454808.chatgpt.site/"},{"@type":"ListItem","position":2,"name":"Library","item":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library"},{"@type":"ListItem","position":3,"name":"Medications","item":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/medications"},{"@type":"ListItem","position":4,"name":"Buspirone (Buspar)","item":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/buspirone-uses-dosage-side-effects"}]},{"@type":"ImageObject","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/buspirone-uses-dosage-side-effects#primaryimage","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/library/editorial-11118.webp","contentUrl":"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/library/editorial-11118.webp","width":1200,"height":633,"encodingFormat":"image/webp","caption":"An adult sits with hands clasped during a conversation."},{"@type":"Person","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/emily-doe#person","name":"Emily Doe","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/emily-doe","jobTitle":"Writer","image":"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/wordpress/3062.jpg","sameAs":["https://www.linkedin.com/in/emily-doe-28a63a79/"]},{"@type":"Person","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/leila-khurshid#person","name":"Leila Khurshid, Pharm.D.","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/leila-khurshid","jobTitle":"Pharm.D., BCPS","image":"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/wordpress/3060.webp","sameAs":["https://www.linkedin.com/in/leila-khurshid-pharmd-bcps/"]},{"@type":"Article","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/buspirone-uses-dosage-side-effects#article","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/buspirone-uses-dosage-side-effects","headline":"Buspirone (Buspar)","description":"Buspirone (BuSpar) is an anti-anxiety drug that treats various anxiety disorders. 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(n.d.). Dailymed.nlm.nih.gov. Retrieved November 25, 2022, from DailyMed","links":[{"url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f3bc8ede-13a3-4119-a47a-8234c80bbc05","label":"DailyMed"}],"url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f3bc8ede-13a3-4119-a47a-8234c80bbc05"},{"number":2,"id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/buspirone-uses-dosage-side-effects#buspar","text":"Bristol-Myers Squibb Company. (2010, November). BuSpar®. Retrieved October 17, 2022, from U.S. Food and Drug Administration","links":[{"url":"https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/018731s051lbl.pdf","label":"U.S. Food and Drug Administration"}],"url":"https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/018731s051lbl.pdf"},{"number":3,"id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/buspirone-uses-dosage-side-effects#buspirone-oral-route","text":"Buspirone (Oral Route). (2022, July 18). Retrieved October 19, 2022, from Mayo Clinic","links":[{"url":"https://www.mayoclinic.org/drugs-supplements/buspirone-oral-route/description/drg-20062457","label":"Mayo Clinic"}],"url":"https://www.mayoclinic.org/drugs-supplements/buspirone-oral-route/description/drg-20062457"},{"number":4,"id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/buspirone-uses-dosage-side-effects#buspirone-interactions","text":"Buspirone Interactions. (n.d.). Drugs.com. Retrieved October 19, 2022, from Drugs.com","links":[{"url":"https://www.drugs.com/drug-interactions/buspirone.html","label":"Drugs.com"}],"url":"https://www.drugs.com/drug-interactions/buspirone.html"},{"number":5,"id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/buspirone-uses-dosage-side-effects#buspirone-medlineplus-drug-information","text":"Buspirone: MedlinePlus Drug Information. (n.d.). Retrieved October 19, 2022, from MedlinePlus","links":[{"url":"https://medlineplus.gov/druginfo/meds/a688005.html","label":"MedlinePlus"}],"url":"https://medlineplus.gov/druginfo/meds/a688005.html"},{"number":6,"id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/buspirone-uses-dosage-side-effects#livertox-clinical-research-information-drug-induced-liver-injury-internet","text":"LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Buspirone. [Updated 2017 Sep 11]. Available from: National Library of Medicine","links":[{"url":"https://www.ncbi.nlm.nih.gov/books/NBK547966/","label":"National Library of Medicine"}],"url":"https://www.ncbi.nlm.nih.gov/books/NBK547966/"},{"number":7,"id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/buspirone-uses-dosage-side-effects#buspirone-social-phobia","text":"Schneier, F. R., Saoud, J. B., Campeas, R., Fallon, B. A., Hollander, E., Coplan, J., & Liebowitz, M. R. (1993). Buspirone in social phobia. Journal of Clinical Psychopharmacology, 13(4), 251–256. Buspirone in social phobia","links":[{"url":"https://doi.org/10.1097/00004714-199308000-00004","label":"Buspirone in social phobia"}],"url":"https://doi.org/10.1097/00004714-199308000-00004"},{"number":8,"id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/buspirone-uses-dosage-side-effects#treasure-island-fl-statpearls-publishing-2022-jan","text":"Wilson TK, Tripp J. Buspirone. [Updated 2022 Sep 2]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. 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