{"formatVersion":"1.1","id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/amisulpride-use-dosage-risk-effects","path":"/library/amisulpride-use-dosage-risk-effects","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/amisulpride-use-dosage-risk-effects","title":"Amisulpride (Solian)","family":"Library detail","description":"Amisulpride (Solian) is an antipsychotic medication used to treat positive symptoms of schizophrenia and other conditions with symptoms of psychosis.","language":"en-US","access":{"audience":"custom-shared-preview","indexable":true},"provenance":{"sourceUrl":"https://www.mentalhealth.com/library/amisulpride-use-dosage-risk-effects","wordpressId":"201","contentCompleteness":"complete","dateScope":"original-source"},"authors":[{"@type":"Person","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/jenni-jacobsen#person","name":"Jenni Jacobsen, Ph.D.","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/jenni-jacobsen"}],"reviewer":{"@type":"Person","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/amy-shelby#person","name":"Amy Shelby","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/amy-shelby"},"dates":{"datePublished":"2022-11-22T20:00:00Z","dateModified":"2025-09-17T06:14:43Z","lastReviewed":"2022-11-23"},"content":{"html":"<nav class=\"breadcrumbs\" aria-label=\"Breadcrumb\"><ol><li><a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/\">Home</a></li><li><a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/library\">Library</a></li><li><a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/medications\">Medications</a></li><li><span aria-current=\"page\">Amisulpride (Solian)</span></li></ol></nav><div class=\"article-page article-standard\" data-library-standard><div class=\"article-main-grid\"><header class=\"article-heading\"><h1>Amisulpride (Solian)</h1><p class=\"article-inline-credits\"><span>Written by <a class=\"article-credit-person\" href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/jenni-jacobsen\"><img src=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/optimized/4f4e4293be2246dfe2e00d7c.jpg\" alt=\"\" width=\"22\" height=\"22\" loading=\"lazy\" decoding=\"async\">Jenni Jacobsen, Ph.D.</a></span><span>Medically reviewed by <a class=\"article-credit-person\" href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/amy-shelby\"><img src=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/optimized/21afa080123d8c48701b6218.jpg\" alt=\"\" width=\"22\" height=\"22\" loading=\"lazy\" decoding=\"async\">Amy Shelby</a></span></p><div class=\"article-dates\"><span>Published on <time datetime=\"2022-11-22T20:00:00Z\">November 22, 2022</time></span><span aria-hidden=\"true\"> · </span><span>Updated on <time datetime=\"2025-09-17T06:14:43Z\">September 17, 2025</time></span></div></header><div class=\"article-jumpbar\"></div><div class=\"article-layout\"><div class=\"article-reading\"><article class=\"prose\" id=\"article-content\"><div class=\"article-intro\" data-source-field=\"hero\"><p>Amisulpride, often sold under the brand name Solian, is an antipsychotic and anti-nausea medication. It is used intravenously in smaller doses to treat postoperative nausea and vomiting, and orally in larger doses to treat schizophrenia in adults.</p></div><figure class=\"article-feature\"><img src=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/optimized/0fecfffcabc40e1412116f32.webp\" alt=\"A healthcare professional explains information to a patient in a clinic.\" width=\"1200\" height=\"738\" loading=\"eager\" decoding=\"async\"></figure><section class=\"article-takeaways\" aria-labelledby=\"key-takeaways\"><h2 id=\"key-takeaways\">Key takeaways</h2><ul><li>Amisulpride is used orally for schizophrenia and intravenously at lower doses for postoperative nausea and vomiting.</li><li>Its effects involve dopamine receptors, and adverse effects can include movement symptoms, drowsiness, and hormonal changes.</li><li>Medication interactions and heart rhythm risks require clinical attention, and overdose can cause serious cardiovascular complications.</li></ul></section><span id=\"amisulpride-brand-names-there-are-various-brand-names-for-amisulpride-the-most-prominent-of-which-is-solian-other-brand-names-include-amgrace-amisure-amisyt-amplicon-aride-barhemsys-bipo-life-doxamil-goldpride-psyride-sizopride-solaze-sulpitac-sulpra-zonapride-and-zulpride\" class=\"section-anchor-alias\" data-section-alias=\"amisulpride-brand-names\" aria-hidden=\"true\"></span><h2 id=\"amisulpride-brand-names\">Amisulpride brand names</h2><p>\nThere are various brand names for amisulpride, the most prominent of which is Solian.\nOther brand names include Amgrace, Amisure, Amisyt, Amplicon, ARIDE, Barhemsys, Bipo-Life, Doxamil, Goldpride, Psyride, Sizopride, Solaze, Sulpitac, Sulpra, Zonapride, and Zulpride.\n</p><span id=\"what-is-amisulpride-prescribed-for-the-primary-use-of-amisulpride-is-as-a-first-line-treatment-for-the-management-of-acute-psychosis\" class=\"section-anchor-alias\" data-section-alias=\"what-is-amisulpride-prescribed-for\" aria-hidden=\"true\"></span><h2 id=\"what-is-amisulpride-prescribed-for\">What is amisulpride prescribed for?</h2><p>\nThe primary use of amisulpride is as a first-line treatment for the management of acute psychosis.<sup><a href=\"#use-amisulpride-treatment-acute-psychosis\" class=\"article-inline-link article-citation\" aria-label=\"Reference 1\">[1]</a></sup> Adults with <a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/schizophrenia\" class=\"article-inline-link\">schizophrenia</a> are often prone to psychotic episodes, where the patient can, along with hallucinations and delusions (positive symptoms), appear “distressed, not necessarily cooperative, out of touch, and agitated”.<sup><a href=\"#use-amisulpride-treatment-acute-psychosis\" class=\"article-inline-link article-citation\" aria-label=\"Reference 1\">[1]</a></sup> The goal of using amisulpride here is to reduce patient distress. It is often associated with the management of agitation and sometimes aggressive behavior.<sup><a href=\"#use-amisulpride-treatment-acute-psychosis\" class=\"article-inline-link article-citation\" aria-label=\"Reference 1\">[1]</a></sup>\n</p><p>Another common use of amisulpride is for treating postoperative nausea and vomiting (PONV). After an operation, patients can often feel nauseous and potentially vomit. This can cause distress for patients and can prolong care requirements.<sup><a href=\"#amisulpride-prevents-postoperative-nausea-vomiting-patients-high-risk-randomized\" class=\"article-inline-link article-citation\" aria-label=\"Reference 2\">[2]</a></sup> If PONV persists after the administration of more conventional first-line anti-nausea prophylaxis, amisulpride has been found to be safe and effective as prophylaxis of postoperative nausea and vomiting when given in combination with an anti-nausea medication from another class.<sup><a href=\"#amisulpride-prevents-postoperative-nausea-vomiting-patients-high-risk-randomized\" class=\"article-inline-link article-citation\" aria-label=\"Reference 2\">[2]</a></sup></p><p>\nStudies have also shown that amisulpride can be very effective in the treatment of depression in patients with schizophrenia, in comparison to the more conventional treatment, risperidone.<sup><a href=\"#amisulpride-versus-risperidone-treatment-depression-patients-schizophrenia-randomized-op\" class=\"article-inline-link article-citation\" aria-label=\"Reference 3\">[3]</a></sup>\n</p><span id=\"how-does-amisulpride-work-when-used-for-treating-schizophrenia-high-doses-of-amisulpride-work-by-blocking-the-dopamine-d2-and-d3-receptors-in-the-brain-these-receptors-help-regulate-our-locomotion-ability-to-move-attention-sleep-memory-learning-cognition-perception-and-understanding-and-impulse-control-the-blocking-of-these-receptors-inhibits-dopamine-production-which-in-turn-reduces-the-symptoms-of-psychosis-hallucinations-delusions-agitation-etc\" class=\"section-anchor-alias\" data-section-alias=\"how-does-amisulpride-work\" aria-hidden=\"true\"></span><h2 id=\"how-does-amisulpride-work\">How does amisulpride work?</h2><p>\nWhen used for treating schizophrenia, high doses of amisulpride work by blocking the dopamine D2 and D3 receptors in the brain. These receptors help regulate our locomotion (ability to move), attention, sleep, memory, learning, cognition (perception and understanding), and impulse control. The blocking of these receptors inhibits dopamine production, which in turn reduces the symptoms of psychosis (hallucinations, delusions, agitation, etc.).<sup><a href=\"#treasure-island-fl-statpearls-publishing-2022-jan\" aria-label=\"Reference 4\" class=\"article-inline-link article-citation\">[4]</a></sup>\n</p><p>When used to treat depression in schizophrenic patients, smaller doses work by blocking the inhibitory receptors in the brain. This helps to increase dopamine production and thus aids with depression and anxiety (negative symptoms of schizophrenia).</p><p>\nWhen used to treat PONV, amisulpride blocks the signals to the brain that cause nausea and vomiting.\n</p><span id=\"how-is-amisulpride-usually-taken-when-used-to-treat-schizophrenia-amisulpride-is-usually-taken-orally-in-tablet-form-the-recommended-daily-dosage-of-oral-amisulpride-is-between-400-and-800-milligrams-per-day\" class=\"section-anchor-alias\" data-section-alias=\"how-is-amisulpride-usually-taken\" aria-hidden=\"true\"></span><h2 id=\"how-is-amisulpride-usually-taken\">How is amisulpride usually taken?</h2><p>\nWhen used to treat schizophrenia, amisulpride is usually taken orally in tablet form. The recommended daily dosage of oral amisulpride is between 400 and 800 milligrams per day.<sup><a href=\"#amisulpride-review-use-management-schizophrenia\" class=\"article-inline-link article-citation\" aria-label=\"Reference 5\">[5]</a></sup>\nWhen used to treat PONV, it is injected intravenously (directly into the veins). The recommended dosage for treating PONV is five to ten milligrams.<sup><a href=\"#thorough-qt-study-effect-intravenous-amisulpride-qtc-interval-caucasian\" class=\"article-inline-link article-citation\" aria-label=\"Reference 6\">[6]</a></sup>\n</p><span id=\"how-long-does-amisulpride-stay-in-and-leave-your-system-after-an-oral-dose-the-elimination-half-life-the-time-it-takes-for-the-full-dosage-of-a-drug-to-reduce-to-half-within-the-body-is-around-12-hours\" class=\"section-anchor-alias\" data-section-alias=\"how-long-does-amisulpride-stay-in-and-leave-your-system\" aria-hidden=\"true\"></span><h2 id=\"how-long-does-amisulpride-stay-in-and-leave-your-system\">How long does amisulpride stay in and leave your system?</h2><p>\nAfter an oral dose, the elimination half-life (the time it takes for the full dosage of a drug to reduce to half within the body) is around 12 hours.\n</p><p>For an intravenous dose, the elimination half-life is four to five hours.</p><p>\nAmisulpride is expelled from the body in the urine.\n</p><span id=\"amisulpride-side-effects-like-most-antipsychotic-medications-amisulpride-can-cause-side-effects-although-the-occurrence-of-side-effects-is-rare-this-is-why-there-are-few-common-side-effects-of-the-medication-and-any-side-effects-from-the-below-warrants-further-medical-advice-you-should\" class=\"section-anchor-alias\" data-section-alias=\"amisulpride-side-effects\" aria-hidden=\"true\"></span><h2 id=\"amisulpride-side-effects\">Amisulpride side effects</h2><p>\nLike most antipsychotic medications, amisulpride can cause side effects, although the occurrence of side effects is rare. This is why there are few common side effects of the medication and any side effects from the below warrants further medical advice.\nYou should <em>stop taking amisulpride immediately</em><em>and seek medical attention</em> if you have any of the following side effects:\n</p><ul>\n    <li>Swelling of the hands, feet, ankles, face, lips, or throat. This can cause difficulty breathing or swallowing and could be accompanied by hives or rashes. This could mean you are having an allergic reaction to amisulpride.</li>\n    <li>Seizures/fits.</li>\n    <li>More frequent infections. This can be caused by a blood disorder or a decrease in white blood count.</li>\n    <li>Chest pain or an unusually fast heartbeat.</li>\n    <li>High temperature, sweating, or stiff muscles.</li>\n    <li>Blood clots (which cause swelling, pain, and redness).</li>\n    <li>Liver failure (symptoms include fatigue, loss of appetite, nausea, vomiting, abdominal pain, or yellow discoloration of the eyes or skin).</li>\n</ul><p>\nA doctor should be contacted <strong>as soon as possible</strong> if any of the following adverse effects are present:\n</p><ul>\n    <li>Trembling, muscle stiffness, spasms, slow movement, overproduction of saliva, or restlessness.</li>\n    <li>Extrapyramidal symptoms (uncontrolled movements in the arms and legs).</li>\n</ul><p>\nOther side effects include:\n</p><ul>\n    <li>Insomnia or anxiety</li>\n    <li>Drowsiness/tiredness</li>\n    <li>Constipation</li>\n    <li>Weight gain</li>\n    <li>Menstrual cycle disturbance</li>\n    <li>Breast enlargement in men</li>\n    <li>Difficulty in getting or maintaining an erection</li>\n    <li>Dizziness</li>\n    <li>Blurred vision</li>\n</ul><span id=\"amisulpride-precautions-before-you-take-amisulpride-inform-your-doctor-if-you\" class=\"section-anchor-alias\" data-section-alias=\"amisulpride-precautions\" aria-hidden=\"true\"></span><h2 id=\"amisulpride-precautions\">Amisulpride precautions</h2><p>\nBefore you take amisulpride, inform your doctor if you:\n</p><ul>\n    <li>Are pregnant, plan on becoming pregnant, or are breast-feeding.</li>\n    <li>Have breast cancer.</li>\n    <li>Have a tumor on their adrenal gland.</li>\n    <li>Are under 18 years of age.</li>\n    <li>Have kidney problems.</li>\n    <li>Have diabetes.</li>\n    <li>Have Parkinson’s disease.</li>\n    <li>Have ever had epileptic fits.</li>\n    <li>Have an irregular heartbeat.</li>\n    <li>Are elderly.</li>\n    <li>Have low levels of potassium in your blood.</li>\n    <li>Are at risk of strokes.</li>\n    <li>Have a low white blood cell count.</li>\n    <li>Have frequent infections (such as fever or sore throat).</li>\n    <li>Have a family history of breast cancer.</li>\n    <li>Have high levels of prolactin (the hormone that causes breast milk production).</li>\n</ul><span id=\"amisulpride-interactions-before-taking-amisulpride-you-should-always-inform-your-doctor-or-pharmacist-if-you-are-taking-other-medications-including-medicines-without-prescriptions-or-herbal-medicines-amisulpride-can-have-adverse-reactions-on-the-way-other-medicines-work-and-vice-versa-tell-your-doctor-if-you-are-taking-any-of-the-following\" class=\"section-anchor-alias\" data-section-alias=\"amisulpride-interactions\" aria-hidden=\"true\"></span><h2 id=\"amisulpride-interactions\">Amisulpride interactions</h2><p>\nBefore taking amisulpride, you should always inform your doctor or pharmacist if you are taking other medications, including medicines without prescriptions or herbal medicines. Amisulpride can have adverse reactions on the way other medicines work and vice versa.\nTell your doctor if you are taking any of the following:\n</p><ul>\n    <li>Levodopa</li>\n    <li>Dopamine agonists (drugs that stimulate parts of the brain influenced by dopamine like ropinirole).</li>\n    <li>Medication to control heart rate (such as quinidine).</li>\n    <li>Clozapine</li>\n    <li>Medication used to control blood pressure and migraines (such as clonidine).</li>\n    <li>Mefloquine</li>\n    <li>Sleep aids such as benzodiazepines and barbiturates.</li>\n    <li>Painkillers (such as tramadol).</li>\n    <li>Anesthetics.</li>\n    <li>Antihistamines like promethazine (which makes you drowsy).</li>\n    <li>Medicines that affect the level of sodium and potassium in the blood (such as laxatives and glucocorticoids).</li>\n</ul><p>\nDo not drink alcohol while taking amisulpride, as it can alter the effect alcohol has on you.\n</p><span id=\"amisulpride-storage-keep-amisulpride-in-a-safe-place-and-out-of-the-reach-of-children-do-not-use-it-when-it-has-passed-its-expiration-date\" class=\"section-anchor-alias\" data-section-alias=\"amisulpride-storage\" aria-hidden=\"true\"></span><h2 id=\"amisulpride-storage\">Amisulpride storage</h2><p>\nKeep amisulpride in a safe place and out of the reach of children. Do not use it when it has passed its expiration date.\n</p><span id=\"what-to-do-if-you-overdose-on-amisulpride-studies-have-shown-that-overdoses-of-amisulpride-can-be-highly-cardiotoxic-harmful-to-the-heart-and-can-cause-various-cardiovascular-responses-including\" class=\"section-anchor-alias\" data-section-alias=\"what-to-do-if-you-overdose-on-amisulpride\" aria-hidden=\"true\"></span><h2 id=\"what-to-do-if-you-overdose-on-amisulpride\">What to do if you overdose on amisulpride</h2><p>\nStudies have shown that overdoses of amisulpride can be highly cardiotoxic (harmful to the heart) and can cause various cardiovascular responses, including:\n</p><ul>\n    <li>QT prolongation (your heart takes longer than usual to recover after each heartbeat).</li>\n    <li>Hypotension (low blood pressure).</li>\n    <li>Bradycardia (slow heart rate).</li>\n    <li>Torsades de Pointes (atypical heart rhythm).<sup><a href=\"#amisulpride-overdose-frequently-associated-qt-prolongation-torsades-de-pointes\" class=\"article-inline-link article-citation\" aria-label=\"Reference 7\">[7]</a></sup></li>\n</ul><p>\nThese conditions can all have potentially dangerous complications, and you should therefore seek medical assistance at the earliest opportunity.</p></article><div class=\"article-endmatter\"><section class=\"article-sources\" id=\"references\" data-source-references=\"\" data-reference-list=\"\" data-reference-style=\"author-date-numbered\"><h2 id=\"references-2\">References</h2><ol>\n    <li id=\"use-amisulpride-treatment-acute-psychosis\" data-reference-number=\"1\">Nuss P, Hummer M, Tessier C. The use of amisulpride in the treatment of acute psychosis. <em>Ther Clin Risk Manag. 2007 Mar;3</em>(1):3-11. doi: 10.2147/tcrm.2007.3.1.3. PMID: 18360610; PMCID: PMC1936283.</li>\n    <li id=\"amisulpride-prevents-postoperative-nausea-vomiting-patients-high-risk-randomized\" data-reference-number=\"2\">Kranke P, Bergese SD, Minkowitz HS, Melson TI, Leiman DG, Candiotti KA, Liu N, Eberhart L, Habib AS, Wallenborn J, Kovac AL, Diemunsch P, Fox G, Gan TJ. Amisulpride prevents postoperative nausea and vomiting in patients at high risk: A randomized, double-blind, placebo-controlled trial. <em>Anesthesiology. 2018 Jun; 128</em>(6):1099-1106. doi: 10.1097/ALN.0000000000002133. PMID: 29543631.</li>\n    <li id=\"amisulpride-versus-risperidone-treatment-depression-patients-schizophrenia-randomized-op\" data-reference-number=\"3\">Kim SW, Shin IS, Kim JM, Lee SH, Lee JH, Yoon BH, Yang SJ, Hwang MY, Yoon JS. Amisulpride versus risperidone in the treatment of depression in patients with schizophrenia: a randomized, open-label, controlled trial. <em>Prog Neuropsychopharmacol Biol Psychiatry. 2007 Oct 1;31</em>(7):1504-9. doi: 10.1016/j.pnpbp.2007.07.005. Epub 2007 Jul 13. PMID: 17692448.</li>\n    <li id=\"treasure-island-fl-statpearls-publishing-2022-jan\" data-reference-number=\"4\">Bhatia A, Lenchner JR, Saadabadi A. <em>Biochemistry, dopamine receptors</em>. [Updated 2022 Jul 18]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan. Available from: <a href=\"https://www.ncbi.nlm.nih.gov/books/NBK538242/?utm_medium=referral&amp;utm_campaign=libra&amp;utm_content=external_resource&amp;utm_id=site-library-amisulpride-use-dosage-risk-effects&amp;utm_source=mentalhealth.com\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">National Library of Medicine</a></li>\n    <li id=\"amisulpride-review-use-management-schizophrenia\" data-reference-number=\"5\">Curran MP, Perry CM. Amisulpride: A review of its use in the management of schizophrenia. <em>Drugs. 2001;61</em>(14):2123-50. doi: 10.2165/00003495-200161140-00014. PMID: 11735643.</li>\n    <li id=\"thorough-qt-study-effect-intravenous-amisulpride-qtc-interval-caucasian\" data-reference-number=\"6\">Täubel J, Ferber G, Fox G, Fernandes S, Lorch U, Camm AJ. Thorough QT study of the effect of intravenous amisulpride on QTc interval in Caucasian and Japanese healthy subjects. <em>Br J Clin Pharmacol. 2017 Feb; 83</em>(2):339-348. doi: 10.1111/bcp.13128. Epub 2016 Oct 21. PMID: 27618796; PMCID: PMC5237697.</li>\n    <li id=\"amisulpride-overdose-frequently-associated-qt-prolongation-torsades-de-pointes\" data-reference-number=\"7\">Isbister GK, Balit CR, Macleod D, Duffull SB. Amisulpride overdose is frequently associated with QT prolongation and torsades de pointes. <em>J Clin Psychopharmacol. 2010 Aug;30</em>(4):391-5. doi: 10.1097/JCP.0b013e3181e5c14c. PMID: 20531221.</li>\n</ol></section><section class=\"article-medical article-panel\"><h2 id=\"medical-content\">Medical Content</h2><p><a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/clinical-affairs\">The Clinical Affairs Team</a> at MentalHealth.com is a dedicated group of medical professionals with diverse and extensive clinical experience. They actively contribute to the development of content, products, and services, and meticulously review all medical material before publication to ensure accuracy and alignment with current research and conversations in mental health. For more information, please visit the <a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/publishing/editorial-policy\">Editorial Policy</a>.</p></section><section class=\"article-about article-panel\"><h2 id=\"about-mentalhealth-com\">About MentalHealth.com</h2><p>MentalHealth.com helps people understand themselves, build healthier relationships, and access the right care. We bring together mental health education, diagnostics, and care management to support well-being throughout every phase of life.</p><div class=\"article-contributors\"><section class=\"article-bio\"><img src=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/optimized/4f4e4293be2246dfe2e00d7c.jpg\" alt=\"\" width=\"64\" height=\"64\" loading=\"lazy\" decoding=\"async\"><div><p class=\"article-bio-role\">Author</p><h3 id=\"jenni-jacobsen-ph-d\"><a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/jenni-jacobsen\">Jenni Jacobsen, Ph.D.</a></h3><p class=\"article-bio-credentials\">Ph.D., LSW, MSW</p><p>Jenni Jacobsen, Ph.D. is a licensed social worker, behavioral health consultant and medical reviewer. She holds a Ph.D. in clinical psychology.</p><dl><div><dt>Published</dt><dd><time datetime=\"2022-11-22T20:00:00Z\">November 22, 2022</time></dd></div><div><dt>Updated</dt><dd><time datetime=\"2025-09-17T06:14:43Z\">September 17, 2025</time></dd></div></dl></div></section><section class=\"article-bio\"><img src=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/optimized/21afa080123d8c48701b6218.jpg\" alt=\"\" width=\"64\" height=\"64\" loading=\"lazy\" decoding=\"async\"><div><p class=\"article-bio-role\">Medical Reviewer</p><h3 id=\"amy-shelby\"><a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/amy-shelby\">Amy Shelby</a></h3><p class=\"article-bio-credentials\">M.S. Counseling Psychology</p><p>Amy Shelby is a medical reviewer with a B.A. in Psychology from Northwestern and an M.S. in Psychology from Chatham University.</p><dl><div><dt>Reviewed</dt><dd><time datetime=\"2022-11-23\">November 23, 2022</time></dd></div></dl></div></section></div></section><section class=\"article-expert article-expert-mobile\" aria-label=\"Subject matter expert\" data-expert-kind=\"related\"><p class=\"article-bio-role\">Subject matter expert</p><div class=\"article-expert-identity\"><img src=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/optimized/90339bb61ace127cee8df5f2.webp\" alt=\"\" width=\"64\" height=\"64\" loading=\"lazy\" decoding=\"async\"><h2><a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/leila-khurshid\">Leila Khurshid, Pharm.D.</a></h2></div><p class=\"article-expert-focus\">Clinical pharmacy and medication</p><a class=\"profile-experience-link experience-button\" href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/leila-khurshid\">View experience</a></section><section class=\"article-topic-community article-topic-community-mobile\" aria-label=\"Related communities\"><img class=\"topic-community-banner\" src=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/optimized/9ae511a8c567ef6fdff00197.webp\" alt=\"\" width=\"48\" height=\"48\" loading=\"lazy\" decoding=\"async\"><p class=\"topic-community-label\">Related communities</p><h2>Medications</h2><p>Explore questions and perspectives about psychiatric medications and the treatment experience.</p><a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/community/medications\">Explore community</a></section></div></div><aside class=\"article-sidebar\" tabindex=\"0\" data-bounded-rail=\"\" aria-label=\"Article navigation and related information\"><details class=\"article-contents\" open data-section-preview=\"3\" data-expanded=\"false\" data-scrolled-past=\"false\"><summary><strong>Table of contents</strong><span aria-hidden=\"true\"></span><small data-current-section=\"\">Choose a section</small></summary><nav aria-label=\"Article contents\"><ol id=\"article-section-list\"><li><a href=\"#amisulpride-brand-names\" title=\"Amisulpride brand names\" aria-label=\"Amisulpride brand names\">Amisulpride brand names</a></li><li><a href=\"#what-is-amisulpride-prescribed-for\" title=\"What is amisulpride prescribed for?\" aria-label=\"What is amisulpride prescribed for?\">What is amisulpride prescribed for?</a></li><li><a href=\"#how-does-amisulpride-work\" title=\"How does amisulpride work?\" aria-label=\"How does amisulpride work?\">How does amisulpride work?</a></li><li><a href=\"#how-is-amisulpride-usually-taken\" title=\"How is amisulpride usually taken?\" aria-label=\"How is amisulpride usually taken?\">How is amisulpride usually taken?</a></li><li><a href=\"#how-long-does-amisulpride-stay-in-and-leave-your-system\" title=\"How long does amisulpride stay in and leave your system?\" aria-label=\"How long does amisulpride stay in and leave your system?\">How long does amisulpride stay in and leave your system?</a></li><li><a href=\"#amisulpride-side-effects\" title=\"Amisulpride side effects\" aria-label=\"Amisulpride side effects\">Amisulpride side effects</a></li><li><a href=\"#amisulpride-precautions\" title=\"Amisulpride precautions\" aria-label=\"Amisulpride precautions\">Amisulpride precautions</a></li><li><a href=\"#amisulpride-interactions\" title=\"Amisulpride interactions\" aria-label=\"Amisulpride interactions\">Amisulpride interactions</a></li><li><a href=\"#amisulpride-storage\" title=\"Amisulpride storage\" aria-label=\"Amisulpride storage\">Amisulpride storage</a></li><li><a href=\"#what-to-do-if-you-overdose-on-amisulpride\" title=\"What to do if you overdose on amisulpride\" aria-label=\"What to do if you overdose on amisulpride\">What to do if you overdose on amisulpride</a></li></ol><button type=\"button\" class=\"article-sections-toggle\" data-sections-toggle aria-controls=\"article-section-list\" aria-expanded=\"false\">View more</button></nav></details><section class=\"article-expert\" aria-label=\"Subject matter expert\" data-expert-kind=\"related\"><p class=\"article-bio-role\">Subject matter expert</p><div class=\"article-expert-identity\"><img src=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/optimized/90339bb61ace127cee8df5f2.webp\" alt=\"\" width=\"64\" height=\"64\" loading=\"lazy\" decoding=\"async\"><h2><a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/leila-khurshid\">Leila Khurshid, Pharm.D.</a></h2></div><p class=\"article-expert-focus\">Clinical pharmacy and medication</p><a class=\"profile-experience-link experience-button\" href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/leila-khurshid\">View experience</a></section><section class=\"article-topic-community\" aria-label=\"Related communities\"><img class=\"topic-community-banner\" src=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/optimized/9ae511a8c567ef6fdff00197.webp\" alt=\"\" width=\"48\" height=\"48\" loading=\"lazy\" decoding=\"async\"><p class=\"topic-community-label\">Related communities</p><h2>Medications</h2><p>Explore questions and perspectives about psychiatric medications and the treatment experience.</p><a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/community/medications\">Explore community</a></section></aside></div></div></div>","text":"HomeLibraryMedicationsAmisulpride (Solian)Amisulpride (Solian)Written by Jenni Jacobsen, Ph.D.Medically reviewed by Amy ShelbyPublished on November 22, 2022 · Updated on September 17, 2025Amisulpride, often sold under the brand name Solian, is an antipsychotic and anti-nausea medication. It is used intravenously in smaller doses to treat postoperative nausea and vomiting, and orally in larger doses to treat schizophrenia in adults.Key takeawaysAmisulpride is used orally for schizophrenia and intravenously at lower doses for postoperative nausea and vomiting.Its effects involve dopamine receptors, and adverse effects can include movement symptoms, drowsiness, and hormonal changes.Medication interactions and heart rhythm risks require clinical attention, and overdose can cause serious cardiovascular complications.Amisulpride brand names There are various brand names for amisulpride, the most prominent of which is Solian. Other brand names include Amgrace, Amisure, Amisyt, Amplicon, ARIDE, Barhemsys, Bipo-Life, Doxamil, Goldpride, Psyride, Sizopride, Solaze, Sulpitac, Sulpra, Zonapride, and Zulpride. What is amisulpride prescribed for? The primary use of amisulpride is as a first-line treatment for the management of acute psychosis.[1] Adults with schizophrenia are often prone to psychotic episodes, where the patient can, along with hallucinations and delusions (positive symptoms), appear “distressed, not necessarily cooperative, out of touch, and agitated”.[1] The goal of using amisulpride here is to reduce patient distress. It is often associated with the management of agitation and sometimes aggressive behavior.[1] Another common use of amisulpride is for treating postoperative nausea and vomiting (PONV). After an operation, patients can often feel nauseous and potentially vomit. This can cause distress for patients and can prolong care requirements.[2] If PONV persists after the administration of more conventional first-line anti-nausea prophylaxis, amisulpride has been found to be safe and effective as prophylaxis of postoperative nausea and vomiting when given in combination with an anti-nausea medication from another class.[2] Studies have also shown that amisulpride can be very effective in the treatment of depression in patients with schizophrenia, in comparison to the more conventional treatment, risperidone.[3] How does amisulpride work? When used for treating schizophrenia, high doses of amisulpride work by blocking the dopamine D2 and D3 receptors in the brain. These receptors help regulate our locomotion (ability to move), attention, sleep, memory, learning, cognition (perception and understanding), and impulse control. The blocking of these receptors inhibits dopamine production, which in turn reduces the symptoms of psychosis (hallucinations, delusions, agitation, etc.).[4] When used to treat depression in schizophrenic patients, smaller doses work by blocking the inhibitory receptors in the brain. This helps to increase dopamine production and thus aids with depression and anxiety (negative symptoms of schizophrenia). When used to treat PONV, amisulpride blocks the signals to the brain that cause nausea and vomiting. How is amisulpride usually taken? When used to treat schizophrenia, amisulpride is usually taken orally in tablet form. The recommended daily dosage of oral amisulpride is between 400 and 800 milligrams per day.[5] When used to treat PONV, it is injected intravenously (directly into the veins). The recommended dosage for treating PONV is five to ten milligrams.[6] How long does amisulpride stay in and leave your system? After an oral dose, the elimination half-life (the time it takes for the full dosage of a drug to reduce to half within the body) is around 12 hours. For an intravenous dose, the elimination half-life is four to five hours. Amisulpride is expelled from the body in the urine. Amisulpride side effects Like most antipsychotic medications, amisulpride can cause side effects, although the occurrence of side effects is rare. This is why there are few common side effects of the medication and any side effects from the below warrants further medical advice. You should stop taking amisulpride immediatelyand seek medical attention if you have any of the following side effects: Swelling of the hands, feet, ankles, face, lips, or throat. This can cause difficulty breathing or swallowing and could be accompanied by hives or rashes. This could mean you are having an allergic reaction to amisulpride. Seizures/fits. More frequent infections. This can be caused by a blood disorder or a decrease in white blood count. Chest pain or an unusually fast heartbeat. High temperature, sweating, or stiff muscles. Blood clots (which cause swelling, pain, and redness). Liver failure (symptoms include fatigue, loss of appetite, nausea, vomiting, abdominal pain, or yellow discoloration of the eyes or skin). A doctor should be contacted as soon as possible if any of the following adverse effects are present: Trembling, muscle stiffness, spasms, slow movement, overproduction of saliva, or restlessness. Extrapyramidal symptoms (uncontrolled movements in the arms and legs). Other side effects include: Insomnia or anxiety Drowsiness/tiredness Constipation Weight gain Menstrual cycle disturbance Breast enlargement in men Difficulty in getting or maintaining an erection Dizziness Blurred vision Amisulpride precautions Before you take amisulpride, inform your doctor if you: Are pregnant, plan on becoming pregnant, or are breast-feeding. Have breast cancer. Have a tumor on their adrenal gland. Are under 18 years of age. Have kidney problems. Have diabetes. Have Parkinson’s disease. Have ever had epileptic fits. Have an irregular heartbeat. Are elderly. Have low levels of potassium in your blood. Are at risk of strokes. Have a low white blood cell count. Have frequent infections (such as fever or sore throat). Have a family history of breast cancer. Have high levels of prolactin (the hormone that causes breast milk production). Amisulpride interactions Before taking amisulpride, you should always inform your doctor or pharmacist if you are taking other medications, including medicines without prescriptions or herbal medicines. Amisulpride can have adverse reactions on the way other medicines work and vice versa. Tell your doctor if you are taking any of the following: Levodopa Dopamine agonists (drugs that stimulate parts of the brain influenced by dopamine like ropinirole). Medication to control heart rate (such as quinidine). Clozapine Medication used to control blood pressure and migraines (such as clonidine). Mefloquine Sleep aids such as benzodiazepines and barbiturates. Painkillers (such as tramadol). Anesthetics. Antihistamines like promethazine (which makes you drowsy). Medicines that affect the level of sodium and potassium in the blood (such as laxatives and glucocorticoids). Do not drink alcohol while taking amisulpride, as it can alter the effect alcohol has on you. Amisulpride storage Keep amisulpride in a safe place and out of the reach of children. Do not use it when it has passed its expiration date. What to do if you overdose on amisulpride Studies have shown that overdoses of amisulpride can be highly cardiotoxic (harmful to the heart) and can cause various cardiovascular responses, including: QT prolongation (your heart takes longer than usual to recover after each heartbeat). Hypotension (low blood pressure). Bradycardia (slow heart rate). Torsades de Pointes (atypical heart rhythm).[7] These conditions can all have potentially dangerous complications, and you should therefore seek medical assistance at the earliest opportunity.References Nuss P, Hummer M, Tessier C. The use of amisulpride in the treatment of acute psychosis. Ther Clin Risk Manag. 2007 Mar;3(1):3-11. doi: 10.2147/tcrm.2007.3.1.3. PMID: 18360610; PMCID: PMC1936283. Kranke P, Bergese SD, Minkowitz HS, Melson TI, Leiman DG, Candiotti KA, Liu N, Eberhart L, Habib AS, Wallenborn J, Kovac AL, Diemunsch P, Fox G, Gan TJ. Amisulpride prevents postoperative nausea and vomiting in patients at high risk: A randomized, double-blind, placebo-controlled trial. Anesthesiology. 2018 Jun; 128(6):1099-1106. doi: 10.1097/ALN.0000000000002133. PMID: 29543631. Kim SW, Shin IS, Kim JM, Lee SH, Lee JH, Yoon BH, Yang SJ, Hwang MY, Yoon JS. Amisulpride versus risperidone in the treatment of depression in patients with schizophrenia: a randomized, open-label, controlled trial. Prog Neuropsychopharmacol Biol Psychiatry. 2007 Oct 1;31(7):1504-9. doi: 10.1016/j.pnpbp.2007.07.005. Epub 2007 Jul 13. PMID: 17692448. Bhatia A, Lenchner JR, Saadabadi A. Biochemistry, dopamine receptors. [Updated 2022 Jul 18]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan. Available from: National Library of Medicine Curran MP, Perry CM. Amisulpride: A review of its use in the management of schizophrenia. Drugs. 2001;61(14):2123-50. doi: 10.2165/00003495-200161140-00014. PMID: 11735643. Täubel J, Ferber G, Fox G, Fernandes S, Lorch U, Camm AJ. Thorough QT study of the effect of intravenous amisulpride on QTc interval in Caucasian and Japanese healthy subjects. Br J Clin Pharmacol. 2017 Feb; 83(2):339-348. doi: 10.1111/bcp.13128. Epub 2016 Oct 21. PMID: 27618796; PMCID: PMC5237697. Isbister GK, Balit CR, Macleod D, Duffull SB. Amisulpride overdose is frequently associated with QT prolongation and torsades de pointes. J Clin Psychopharmacol. 2010 Aug;30(4):391-5. doi: 10.1097/JCP.0b013e3181e5c14c. PMID: 20531221. Medical ContentThe Clinical Affairs Team at MentalHealth.com is a dedicated group of medical professionals with diverse and extensive clinical experience. They actively contribute to the development of content, products, and services, and meticulously review all medical material before publication to ensure accuracy and alignment with current research and conversations in mental health. For more information, please visit the Editorial Policy.About MentalHealth.comMentalHealth.com helps people understand themselves, build healthier relationships, and access the right care. We bring together mental health education, diagnostics, and care management to support well-being throughout every phase of life.AuthorJenni Jacobsen, Ph.D.Ph.D., LSW, MSWJenni Jacobsen, Ph.D. is a licensed social worker, behavioral health consultant and medical reviewer. She holds a Ph.D. in clinical psychology.PublishedNovember 22, 2022UpdatedSeptember 17, 2025Medical ReviewerAmy ShelbyM.S. Counseling PsychologyAmy Shelby is a medical reviewer with a B.A. in Psychology from Northwestern and an M.S. in Psychology from Chatham University.ReviewedNovember 23, 2022Subject matter expertLeila Khurshid, Pharm.D.Clinical pharmacy and medicationView experienceRelated communitiesMedicationsExplore questions and perspectives about psychiatric medications and the treatment experience.Explore communityTable of contentsChoose a sectionAmisulpride brand namesWhat is amisulpride prescribed for?How does amisulpride work?How is amisulpride usually taken?How long does amisulpride stay in and leave your system?Amisulpride side effectsAmisulpride precautionsAmisulpride interactionsAmisulpride storageWhat to do if you overdose on amisulprideView moreSubject matter expertLeila Khurshid, Pharm.D.Clinical pharmacy and medicationView experienceRelated communitiesMedicationsExplore questions and perspectives about psychiatric medications and the treatment experience.Explore community","wordCount":1599},"schema":{"@context":"https://schema.org","@graph":[{"@type":"Organization","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/#organization","name":"MentalHealth.com","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/"},{"@type":"WebSite","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/#website","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/","name":"MentalHealth.com","inLanguage":"en-US","publisher":{"@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/#organization"}},{"@type":"BreadcrumbList","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/amisulpride-use-dosage-risk-effects#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://mentalhealth-v2.workspace-454808.chatgpt.site/"},{"@type":"ListItem","position":2,"name":"Library","item":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library"},{"@type":"ListItem","position":3,"name":"Medications","item":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/medications"},{"@type":"ListItem","position":4,"name":"Amisulpride (Solian)","item":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/amisulpride-use-dosage-risk-effects"}]},{"@type":"ImageObject","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/amisulpride-use-dosage-risk-effects#primaryimage","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/optimized/0fecfffcabc40e1412116f32.webp","contentUrl":"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/optimized/0fecfffcabc40e1412116f32.webp","width":1200,"height":738,"encodingFormat":"image/webp","caption":"A healthcare professional explains information to a patient in a clinic."},{"@type":"Person","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/jenni-jacobsen#person","name":"Jenni Jacobsen, Ph.D.","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/jenni-jacobsen","jobTitle":"Ph.D., LSW, MSW","image":"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/optimized/4f4e4293be2246dfe2e00d7c.jpg"},{"@type":"Person","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/amy-shelby#person","name":"Amy Shelby","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/amy-shelby","jobTitle":"M.S. 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Shelby","level":3,"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/amisulpride-use-dosage-risk-effects#amy-shelby"}],"references":[{"number":1,"id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/amisulpride-use-dosage-risk-effects#use-amisulpride-treatment-acute-psychosis","text":"Nuss P, Hummer M, Tessier C. The use of amisulpride in the treatment of acute psychosis. Ther Clin Risk Manag. 2007 Mar;3(1):3-11. doi: 10.2147/tcrm.2007.3.1.3. PMID: 18360610; PMCID: PMC1936283.","links":[]},{"number":2,"id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/amisulpride-use-dosage-risk-effects#amisulpride-prevents-postoperative-nausea-vomiting-patients-high-risk-randomized","text":"Kranke P, Bergese SD, Minkowitz HS, Melson TI, Leiman DG, Candiotti KA, Liu N, Eberhart L, Habib AS, Wallenborn J, Kovac AL, Diemunsch P, Fox G, Gan TJ. Amisulpride prevents postoperative nausea and vomiting in patients at high risk: A randomized, double-blind, placebo-controlled trial. Anesthesiology. 2018 Jun; 128(6):1099-1106. doi: 10.1097/ALN.0000000000002133. PMID: 29543631.","links":[]},{"number":3,"id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/amisulpride-use-dosage-risk-effects#amisulpride-versus-risperidone-treatment-depression-patients-schizophrenia-randomized-op","text":"Kim SW, Shin IS, Kim JM, Lee SH, Lee JH, Yoon BH, Yang SJ, Hwang MY, Yoon JS. Amisulpride versus risperidone in the treatment of depression in patients with schizophrenia: a randomized, open-label, controlled trial. Prog Neuropsychopharmacol Biol Psychiatry. 2007 Oct 1;31(7):1504-9. doi: 10.1016/j.pnpbp.2007.07.005. Epub 2007 Jul 13. PMID: 17692448.","links":[]},{"number":4,"id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/amisulpride-use-dosage-risk-effects#treasure-island-fl-statpearls-publishing-2022-jan","text":"Bhatia A, Lenchner JR, Saadabadi A. Biochemistry, dopamine receptors. [Updated 2022 Jul 18]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan. Available from: National Library of Medicine","links":[{"url":"https://www.ncbi.nlm.nih.gov/books/NBK538242/?utm_medium=referral&utm_campaign=libra&utm_content=external_resource&utm_id=site-library-amisulpride-use-dosage-risk-effects&utm_source=mentalhealth.com","label":"National Library of Medicine"}],"url":"https://www.ncbi.nlm.nih.gov/books/NBK538242/?utm_medium=referral&utm_campaign=libra&utm_content=external_resource&utm_id=site-library-amisulpride-use-dosage-risk-effects&utm_source=mentalhealth.com"},{"number":5,"id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/amisulpride-use-dosage-risk-effects#amisulpride-review-use-management-schizophrenia","text":"Curran MP, Perry CM. Amisulpride: A review of its use in the management of schizophrenia. Drugs. 2001;61(14):2123-50. doi: 10.2165/00003495-200161140-00014. PMID: 11735643.","links":[]},{"number":6,"id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/amisulpride-use-dosage-risk-effects#thorough-qt-study-effect-intravenous-amisulpride-qtc-interval-caucasian","text":"Täubel J, Ferber G, Fox G, Fernandes S, Lorch U, Camm AJ. Thorough QT study of the effect of intravenous amisulpride on QTc interval in Caucasian and Japanese healthy subjects. Br J Clin Pharmacol. 2017 Feb; 83(2):339-348. doi: 10.1111/bcp.13128. Epub 2016 Oct 21. PMID: 27618796; PMCID: PMC5237697.","links":[]},{"number":7,"id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/amisulpride-use-dosage-risk-effects#amisulpride-overdose-frequently-associated-qt-prolongation-torsades-de-pointes","text":"Isbister GK, Balit CR, Macleod D, Duffull SB. Amisulpride overdose is frequently associated with QT prolongation and torsades de pointes. J Clin Psychopharmacol. 2010 Aug;30(4):391-5. doi: 10.1097/JCP.0b013e3181e5c14c. PMID: 20531221.","links":[]}],"relatedReading":[],"links":[{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/","label":"Home"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library","label":"Library"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/medications","label":"Medications"},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/jenni-jacobsen","label":"Jenni Jacobsen, Ph.D."},{"url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/amy-shelby","label":"Amy 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