{"formatVersion":"1.1","id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/amantadine","path":"/library/amantadine","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/amantadine","title":"Amantadine","family":"Library detail","description":"Amantadine is an antiviral drug for treating Parkinson's disease and other spasmodic conditions. Learn more about how it is used, interactions, and more.","language":"en-US","access":{"audience":"custom-shared-preview","indexable":true},"provenance":{"sourceUrl":"https://www.mentalhealth.com/library/amantadine","wordpressId":"206","contentCompleteness":"complete","dateScope":"original-source"},"authors":[{"@type":"Person","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/aimee-aveyard#person","name":"Aimee Aveyard","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/aimee-aveyard"}],"reviewer":{"@type":"Person","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/leila-khurshid#person","name":"Leila Khurshid, Pharm.D.","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/leila-khurshid"},"dates":{"datePublished":"2022-11-23T09:21:15Z","dateModified":"2025-08-12T06:08:02Z","lastReviewed":"2022-11-25"},"content":{"html":"<nav class=\"breadcrumbs\" aria-label=\"Breadcrumb\"><ol><li><a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/\">Home</a></li><li><a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/library\">Library</a></li><li><a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/medications\">Medications</a></li><li><span aria-current=\"page\">Amantadine</span></li></ol></nav><div class=\"article-page article-standard\" data-library-standard><div class=\"article-main-grid\"><header class=\"article-heading\"><h1>Amantadine</h1><p class=\"article-inline-credits\"><span>Written by <a class=\"article-credit-person\" href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/aimee-aveyard\"><img src=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/optimized/aa73bd6706aa504d661d1292.jpg\" alt=\"\" width=\"22\" height=\"22\" loading=\"lazy\" decoding=\"async\">Aimee Aveyard</a></span><span>Medically reviewed by <a class=\"article-credit-person\" href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/leila-khurshid\"><img src=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/optimized/90339bb61ace127cee8df5f2.webp\" alt=\"\" width=\"22\" height=\"22\" loading=\"lazy\" decoding=\"async\">Leila Khurshid, Pharm.D.</a></span></p><div class=\"article-dates\"><span>Published on <time datetime=\"2022-11-23T09:21:15Z\">November 23, 2022</time></span><span aria-hidden=\"true\"> · </span><span>Updated on <time datetime=\"2025-08-12T06:08:02Z\">August 12, 2025</time></span></div></header><div class=\"article-jumpbar\"></div><div class=\"article-layout\"><div class=\"article-reading\"><article class=\"prose\" id=\"article-content\"><div class=\"article-intro\" data-source-field=\"hero\"><p>Amantadine is a medication that was originally developed as an influenza drug and is now primarily used to counteract the side effects of medication for Parkinson’s disease. It can also be used to treat certain mental health conditions, including obsessive-compulsive disorder, treatment-resistant depression and others, such as attention deficit hyperactivity disorder and autism.</p></div><figure class=\"article-feature\"><img src=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/optimized/72acaa4c581c77135c102a52.webp\" alt=\"A man speaks with a counselor in a comfortable room.\" width=\"1200\" height=\"800\" loading=\"eager\" decoding=\"async\"></figure><section class=\"article-takeaways\" aria-labelledby=\"key-takeaways\"><h2 id=\"key-takeaways\">Key takeaways</h2><ul><li>Amantadine is used for Parkinson-related symptoms and may be prescribed for selected mental health conditions.</li><li>Side effects can include confusion, low blood pressure, hallucinations, and compulsive behaviors.</li><li>Abrupt discontinuation can cause serious adverse effects, so treatment changes require medical guidance.</li></ul></section><h2 id=\"amantadine-brand-names\">Amantadine brand names</h2><p>Amantadine is sold under the brand names Gocovri, Osmolex ER, Symadine and Symmetrel.</p><h2 id=\"what-is-amantadine-prescribed-for\">What is amantadine prescribed for?</h2><p>Amantadine was originally developed as an antiviral drug to treat the flu.<sup><a href=\"#amantadine-medication-info-sheets\" aria-label=\"Reference 1\" class=\"article-inline-link article-citation\">[1]</a></sup></p><p>It is used to counteract the side effects of medication for Parkinson’s disease and can be used in combination with other drugs to directly treat symptoms of Parkinson’s disease.<sup><a href=\"#amantadine-medlineplus-drug-information\" aria-label=\"Reference 2\" class=\"article-inline-link article-citation\">[2]</a></sup></p><p>It can be prescribed for certain mental health disorders and other conditions related to the brain, such as:<sup><a href=\"#amantadine-medication-info-sheets\" aria-label=\"Reference 1\" class=\"article-inline-link article-citation\">[1]</a></sup></p><ul><li><a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/obsessive-compulsive-disorder\" class=\"article-inline-link\">Obsessive-compulsive disorder (OCD)</a></li><li><a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/managing-persistent-depression\" class=\"article-inline-link\">Treatment-resistant depression</a></li><li>Attention deficit hyperactivity disorder (ADHD)</li><li><a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/autism-spectrum-disorder\" class=\"article-inline-link\">Autism spectrum disorder (ASD)</a></li></ul><h2 id=\"how-does-amantadine-work\">How does amantadine work?</h2><p>As with many drugs, the exact mechanism of action by which amantadine works is not fully understood.<sup><a href=\"#dailymed-amantadine-capsule\" aria-label=\"Reference 3\" class=\"article-inline-link article-citation\">[3]</a></sup> It is an antiviral agent and prevents the flu virus from spreading. It affects the release of dopamine, a chemical in the brain that is involved in several processes in the body, including sleep, mood, attention and movement.</p><h2 id=\"how-is-amantadine-usually-taken\">How is amantadine usually taken?</h2><p>Amantadine comes in different forms, including capsules and tablets, slow-release capsules and tablets, and an oral liquid. Amantadine is usually taken once or twice a day and should be taken at the same time each day.</p><p>The dose will be decided by a doctor or mental health professional and will consider the severity of your symptoms and other conditions and medications.</p><h2 id=\"how-long-does-amantadine-stay-in-your-system\">How long does amantadine stay in your system?</h2><p>Amantadine has a half-life of around 15 hours, on average, which is the time it takes for the body to break down and eliminate half of the dose. The half-life varies from person to person.<sup><a href=\"#amantadine-hydrochloride-100mg-capsules-summary-product-characteristics-smpc\" aria-label=\"Reference 4\" class=\"article-inline-link article-citation\">[4]</a></sup></p><h2 id=\"amantadine-side-effects\">Amantadine side effects</h2><p>Like all medications,</p><p>Common side effects of amantadine include:<sup><a href=\"#amantadine-medlineplus-drug-information\" aria-label=\"Reference 2\" class=\"article-inline-link article-citation\">[2]</a></sup><sup><a href=\"#amantadine-hydrochloride-100mg-capsules-summary-product-characteristics-smpc\" aria-label=\"Reference 4\" class=\"article-inline-link article-citation\">[4]</a></sup></p><ul><li>Dry mouth</li><li>Constipation, nausea and vomiting</li><li>Less of an appetite than usual</li><li>Sleep problems</li><li>Headaches</li><li>Drowsiness and confusion</li><li>Low blood pressure</li><li>Muscle spasms and contractions, problems walking</li><li>Purple or red marks on the skin</li></ul><p>You should discuss side effects with your doctor.</p><p>If you feel drowsy or experience blurred vision, you should avoid driving and operating heavy machinery.</p><p>Seek medical attention for the following more serious side effects right away:<sup><a href=\"#amantadine-medlineplus-drug-information\" aria-label=\"Reference 2\" class=\"article-inline-link article-citation\">[2]</a></sup></p><ul><li>Hallucinations</li><li>Paranoia</li><li>Depression, low mood and/or anxiety</li><li>Suicidal ideation</li><li>Dizziness or fainting</li><li>Blurred vision</li><li>Swollen limbs, joints, hands or feet</li><li>Urinary retention</li><li>Shortness of breath</li></ul><p>Some people have developed gambling problems or other compulsive behaviors after taking amantadine. Tell your doctor or healthcare provider if you become aware that you are developing intense urges to spend, eat, have sex or gamble.<sup><a href=\"#amantadine-medlineplus-drug-information\" aria-label=\"Reference 2\" class=\"article-inline-link article-citation\">[2]</a></sup></p><h2 id=\"amantadine-precautions\">Amantadine precautions</h2><p>Before prescribing amantadine, your doctor should discuss your medical history, any health problems you have, medications you are taking and any allergies. In particular, make sure you tell them:<sup><a href=\"#amantadine-medlineplus-drug-information\" aria-label=\"Reference 2\" class=\"article-inline-link article-citation\">[2]</a></sup></p><ul><li>If you are allergic to any of the ingredients in amantadine</li><li>Any other medication you are taking, including supplements and herbal remedies</li><li>If you have kidney disease</li><li>If you have or have had a problem with alcohol or other drugs</li><li>If you have any other physical or mental illness</li><li>If you are pregnant, trying for a baby or breastfeeding</li></ul><p>You should not stop taking amantadine suddenly, as this can cause serious adverse effects, including psychosis, muscle problems, slurred speech, and fever.<sup><a href=\"#amantadine-medlineplus-drug-information\" aria-label=\"Reference 2\" class=\"article-inline-link article-citation\">[2]</a></sup></p><h2 id=\"amantadine-interactions\">Amantadine interactions</h2><p>Amantadine can interact with other medications, drugs and alcohol. Make sure you discuss any medication, supplement, herbal remedies or other substances you are taking with your doctor.</p><p>Amantadine can seriously interact with the dementia drug memantine, increasing the risk of central nervous system toxicity.<sup><a href=\"#amantadine-interactions-source\" aria-label=\"Reference 5\" class=\"article-inline-link article-citation\">[5]</a></sup> It can also interact with other drugs that act on the central nervous system, such as levodopa (prescribed for Parkinson’s disease).<sup><a href=\"#amantadine-hydrochloride-100mg-capsules-summary-product-characteristics-smpc\" aria-label=\"Reference 4\" class=\"article-inline-link article-citation\">[4]</a></sup></p><p>Taking amantadine with antipsychotic drugs can increase the risk of psychosis.<sup><a href=\"#amantadine-hydrochloride-100mg-capsules-summary-product-characteristics-smpc\" aria-label=\"Reference 4\" class=\"article-inline-link article-citation\">[4]</a></sup></p><p>Some diuretic medications can affect the rate at which amantadine is removed from the body, which can cause adverse reactions.<sup><a href=\"#amantadine-hydrochloride-100mg-capsules-summary-product-characteristics-smpc\" aria-label=\"Reference 4\" class=\"article-inline-link article-citation\">[4]</a></sup></p><h2 id=\"amantadine-storage\">Amantadine storage</h2><p>Amantadine should be stored at room temperature (68-77°F or 20-25°C), away from light and moisture. Always keep medication with the original packaging to check the date and instructions for use. Keep all medication away from children.<sup><a>[6]</a></sup></p><h2 id=\"what-to-do-if-you-overdose-on-amantadine\">What to do if you overdose on amantadine</h2><p>It is possible to overdose on amantadine. The symptoms of an overdose include:<sup><a href=\"#amantadine-medlineplus-drug-information\" aria-label=\"Reference 2\" class=\"article-inline-link article-citation\">[2]</a></sup></p><ul><li>Increased heart rate</li><li>Breathing problems</li><li>Reduced urination</li><li>Swollen limbs, joints, hands or feet</li><li>Stiffness of the limbs</li><li>Involuntary movement of parts of the body, including shaking</li><li>Difficulty with coordination</li><li>Confusion</li><li>Disassociation – feeling disconnected from yourself or your surroundings</li><li>Fear or anger</li><li>Hallucinations</li><li>Feeling lethargic</li></ul><p>If you take too much amantadine, contact the Poison Helpline at 1-800-222-1222 or seek emergency medical help immediately.</p><h2 id=\"what-happens-when-you-stop-taking-amantadine\">What happens when you stop taking amantadine?</h2><p>Do not stop taking amantadine without medical advice from your doctor. Suddenly stopping amantadine can lead to serious consequences, including psychosis, muscle problems, and fever.<sup><a href=\"#amantadine-medlineplus-drug-information\" aria-label=\"Reference 2\" class=\"article-inline-link article-citation\">[2]</a></sup></p></article><div class=\"article-endmatter\"><section class=\"article-sources\" id=\"references\" data-source-references=\"\" data-reference-list=\"\" data-reference-style=\"author-date-numbered\"><h2 id=\"references-2\">References</h2><ol>\n    <li id=\"amantadine-medication-info-sheets\" data-reference-number=\"1\"><em>Amantadine: Medication Info Sheets</em>. (n.d.). Children’s Hospital of Eastern Ontario (CHEO). Retrieved November 15, 2022, from <a href=\"https://www.ementalhealth.ca/Toronto/Amantadine/index.php?m=article&amp;ID=78757&amp;utm_medium=referral&amp;utm_campaign=libra&amp;utm_content=external_resource&amp;utm_id=site-library-amantadine&amp;utm_source=mentalhealth.com\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">Amantadine: Medication Info Sheets</a></li>\n    <li id=\"amantadine-medlineplus-drug-information\" data-reference-number=\"2\"><em>Amantadine: MedlinePlus Drug Information</em>. (2021, June 15). MedlinePlus. Retrieved November 15, 2022, from <a href=\"https://medlineplus.gov/druginfo/meds/a682064.html?utm_medium=referral&amp;utm_campaign=libra&amp;utm_content=external_resource&amp;utm_id=site-library-amantadine&amp;utm_source=mentalhealth.com\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">MedlinePlus</a></li>\n    <li id=\"dailymed-amantadine-capsule\" data-reference-number=\"3\"><em>DailyMed - AMANTADINE capsule</em>. (n.d.). Dailymed.nlm.nih.gov. Retrieved November 25, 2022, from <a href=\"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4157d9a7-a53f-4dde-b051-fe3e9a674913&amp;utm_medium=referral&amp;utm_campaign=libra&amp;utm_content=external_resource&amp;utm_id=site-library-amantadine&amp;utm_source=mentalhealth.com\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">DailyMed</a></li>\n    <li id=\"amantadine-hydrochloride-100mg-capsules-summary-product-characteristics-smpc\" data-reference-number=\"4\"><em>Amantadine hydrochloride 100mg capsules - Summary of Product Characteristics (SmPC)</em>. (n.d.). Retrieved November 15, 2022, from <a href=\"https://www.medicines.org.uk/emc/product/12143/smpc?utm_medium=referral&amp;utm_campaign=libra&amp;utm_content=external_resource&amp;utm_id=site-library-amantadine&amp;utm_source=mentalhealth.com#gref\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">Electronic Medicines Compendium</a></li>\n    <li id=\"amantadine-interactions-source\" data-reference-number=\"5\"><em>Amantadine: Interactions</em>. (n.d.). National Institute for Health and Care Excellence. Retrieved November 15, 2022, from <a href=\"https://bnf.nice.org.uk/interactions/amantadine/?utm_medium=referral&amp;utm_campaign=libra&amp;utm_content=external_resource&amp;utm_id=site-library-amantadine&amp;utm_source=mentalhealth.com\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">Amantadine: Interactions</a></li>\n</ol></section><section class=\"article-medical article-panel\"><h2 id=\"medical-content\">Medical Content</h2><p><a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/clinical-affairs\">The Clinical Affairs Team</a> at MentalHealth.com is a dedicated group of medical professionals with diverse and extensive clinical experience. They actively contribute to the development of content, products, and services, and meticulously review all medical material before publication to ensure accuracy and alignment with current research and conversations in mental health. For more information, please visit the <a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/publishing/editorial-policy\">Editorial Policy</a>.</p></section><section class=\"article-about article-panel\"><h2 id=\"about-mentalhealth-com\">About MentalHealth.com</h2><p>MentalHealth.com helps people understand themselves, build healthier relationships, and access the right care. We bring together mental health education, diagnostics, and care management to support well-being throughout every phase of life.</p><div class=\"article-contributors\"><section class=\"article-bio\"><img src=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/optimized/aa73bd6706aa504d661d1292.jpg\" alt=\"\" width=\"64\" height=\"64\" loading=\"lazy\" decoding=\"async\"><div><p class=\"article-bio-role\">Author</p><h3 id=\"aimee-aveyard\"><a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/aimee-aveyard\">Aimee Aveyard</a></h3><p class=\"article-bio-credentials\">Writer</p><p>Aimee Aveyard is a medical writer with 20+ years of experience in communications.</p><dl><div><dt>Published</dt><dd><time datetime=\"2022-11-23T09:21:15Z\">November 23, 2022</time></dd></div><div><dt>Updated</dt><dd><time datetime=\"2025-08-12T06:08:02Z\">August 12, 2025</time></dd></div></dl></div></section><section class=\"article-bio\"><img src=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/optimized/90339bb61ace127cee8df5f2.webp\" alt=\"\" width=\"64\" height=\"64\" loading=\"lazy\" decoding=\"async\"><div><p class=\"article-bio-role\">Medical Reviewer</p><h3 id=\"leila-khurshid-pharm-d\"><a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/leila-khurshid\">Leila Khurshid, Pharm.D.</a></h3><p class=\"article-bio-credentials\">Pharm.D., BCPS</p><p>Leila Khursid is a medical reviewer with a Doctor of Pharmacy degree and completed a PGY1 Pharmacy Residency from St. Mark's Hospital.</p><dl><div><dt>Reviewed</dt><dd><time datetime=\"2022-11-25\">November 25, 2022</time></dd></div></dl></div></section></div></section><section class=\"article-expert article-expert-mobile\" aria-label=\"Subject matter expert\" data-expert-kind=\"related\"><p class=\"article-bio-role\">Subject matter expert</p><div class=\"article-expert-identity\"><img src=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/optimized/90339bb61ace127cee8df5f2.webp\" alt=\"\" width=\"64\" height=\"64\" loading=\"lazy\" decoding=\"async\"><h2><a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/leila-khurshid\">Leila Khurshid, Pharm.D.</a></h2></div><p class=\"article-expert-focus\">Clinical pharmacy and medication</p><a class=\"profile-experience-link experience-button\" href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/leila-khurshid\">View experience</a></section><section class=\"article-topic-community article-topic-community-mobile\" aria-label=\"Related communities\"><img class=\"topic-community-banner\" src=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/optimized/9ae511a8c567ef6fdff00197.webp\" alt=\"\" width=\"48\" height=\"48\" loading=\"lazy\" decoding=\"async\"><p class=\"topic-community-label\">Related communities</p><h2>Medications</h2><p>Explore questions and perspectives about psychiatric medications and the treatment experience.</p><a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/community/medications\">Explore community</a></section></div></div><aside class=\"article-sidebar\" tabindex=\"0\" data-bounded-rail=\"\" aria-label=\"Article navigation and related information\"><details class=\"article-contents\" open data-section-preview=\"3\" data-expanded=\"false\" data-scrolled-past=\"false\"><summary><strong>Table of contents</strong><span aria-hidden=\"true\"></span><small data-current-section=\"\">Choose a section</small></summary><nav aria-label=\"Article contents\"><ol id=\"article-section-list\"><li><a href=\"#amantadine-brand-names\" title=\"Amantadine brand names\" aria-label=\"Amantadine brand names\">Amantadine brand names</a></li><li><a href=\"#what-is-amantadine-prescribed-for\" title=\"What is amantadine prescribed for?\" aria-label=\"What is amantadine prescribed for?\">What is amantadine prescribed for?</a></li><li><a href=\"#how-does-amantadine-work\" title=\"How does amantadine work?\" aria-label=\"How does amantadine work?\">How does amantadine work?</a></li><li><a href=\"#how-is-amantadine-usually-taken\" title=\"How is amantadine usually taken?\" aria-label=\"How is amantadine usually taken?\">How is amantadine usually taken?</a></li><li><a href=\"#how-long-does-amantadine-stay-in-your-system\" title=\"How long does amantadine stay in your system?\" aria-label=\"How long does amantadine stay in your system?\">How long does amantadine stay in your system?</a></li><li><a href=\"#amantadine-side-effects\" title=\"Amantadine side effects\" aria-label=\"Amantadine side effects\">Amantadine side effects</a></li><li><a href=\"#amantadine-precautions\" title=\"Amantadine precautions\" aria-label=\"Amantadine precautions\">Amantadine precautions</a></li><li><a href=\"#amantadine-interactions\" title=\"Amantadine interactions\" aria-label=\"Amantadine interactions\">Amantadine interactions</a></li><li><a href=\"#amantadine-storage\" title=\"Amantadine storage\" aria-label=\"Amantadine storage\">Amantadine storage</a></li><li><a href=\"#what-to-do-if-you-overdose-on-amantadine\" title=\"What to do if you overdose on amantadine\" aria-label=\"What to do if you overdose on amantadine\">What to do if you overdose on amantadine</a></li><li><a href=\"#what-happens-when-you-stop-taking-amantadine\" title=\"What happens when you stop taking amantadine?\" aria-label=\"What happens when you stop taking amantadine?\">What happens when you stop taking amantadine?</a></li></ol><button type=\"button\" class=\"article-sections-toggle\" data-sections-toggle aria-controls=\"article-section-list\" aria-expanded=\"false\">View more</button></nav></details><section class=\"article-expert\" aria-label=\"Subject matter expert\" data-expert-kind=\"related\"><p class=\"article-bio-role\">Subject matter expert</p><div class=\"article-expert-identity\"><img src=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/optimized/90339bb61ace127cee8df5f2.webp\" alt=\"\" width=\"64\" height=\"64\" loading=\"lazy\" decoding=\"async\"><h2><a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/leila-khurshid\">Leila Khurshid, Pharm.D.</a></h2></div><p class=\"article-expert-focus\">Clinical pharmacy and medication</p><a class=\"profile-experience-link experience-button\" href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/leila-khurshid\">View experience</a></section><section class=\"article-topic-community\" aria-label=\"Related communities\"><img class=\"topic-community-banner\" src=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/optimized/9ae511a8c567ef6fdff00197.webp\" alt=\"\" width=\"48\" height=\"48\" loading=\"lazy\" decoding=\"async\"><p class=\"topic-community-label\">Related communities</p><h2>Medications</h2><p>Explore questions and perspectives about psychiatric medications and the treatment experience.</p><a href=\"https://mentalhealth-v2.workspace-454808.chatgpt.site/community/medications\">Explore community</a></section></aside></div></div></div>","text":"HomeLibraryMedicationsAmantadineAmantadineWritten by Aimee AveyardMedically reviewed by Leila Khurshid, Pharm.D.Published on November 23, 2022 · Updated on August 12, 2025Amantadine is a medication that was originally developed as an influenza drug and is now primarily used to counteract the side effects of medication for Parkinson’s disease. It can also be used to treat certain mental health conditions, including obsessive-compulsive disorder, treatment-resistant depression and others, such as attention deficit hyperactivity disorder and autism.Key takeawaysAmantadine is used for Parkinson-related symptoms and may be prescribed for selected mental health conditions.Side effects can include confusion, low blood pressure, hallucinations, and compulsive behaviors.Abrupt discontinuation can cause serious adverse effects, so treatment changes require medical guidance.Amantadine brand namesAmantadine is sold under the brand names Gocovri, Osmolex ER, Symadine and Symmetrel.What is amantadine prescribed for?Amantadine was originally developed as an antiviral drug to treat the flu.[1]It is used to counteract the side effects of medication for Parkinson’s disease and can be used in combination with other drugs to directly treat symptoms of Parkinson’s disease.[2]It can be prescribed for certain mental health disorders and other conditions related to the brain, such as:[1]Obsessive-compulsive disorder (OCD)Treatment-resistant depressionAttention deficit hyperactivity disorder (ADHD)Autism spectrum disorder (ASD)How does amantadine work?As with many drugs, the exact mechanism of action by which amantadine works is not fully understood.[3] It is an antiviral agent and prevents the flu virus from spreading. It affects the release of dopamine, a chemical in the brain that is involved in several processes in the body, including sleep, mood, attention and movement.How is amantadine usually taken?Amantadine comes in different forms, including capsules and tablets, slow-release capsules and tablets, and an oral liquid. Amantadine is usually taken once or twice a day and should be taken at the same time each day.The dose will be decided by a doctor or mental health professional and will consider the severity of your symptoms and other conditions and medications.How long does amantadine stay in your system?Amantadine has a half-life of around 15 hours, on average, which is the time it takes for the body to break down and eliminate half of the dose. The half-life varies from person to person.[4]Amantadine side effectsLike all medications,Common side effects of amantadine include:[2][4]Dry mouthConstipation, nausea and vomitingLess of an appetite than usualSleep problemsHeadachesDrowsiness and confusionLow blood pressureMuscle spasms and contractions, problems walkingPurple or red marks on the skinYou should discuss side effects with your doctor.If you feel drowsy or experience blurred vision, you should avoid driving and operating heavy machinery.Seek medical attention for the following more serious side effects right away:[2]HallucinationsParanoiaDepression, low mood and/or anxietySuicidal ideationDizziness or faintingBlurred visionSwollen limbs, joints, hands or feetUrinary retentionShortness of breathSome people have developed gambling problems or other compulsive behaviors after taking amantadine. Tell your doctor or healthcare provider if you become aware that you are developing intense urges to spend, eat, have sex or gamble.[2]Amantadine precautionsBefore prescribing amantadine, your doctor should discuss your medical history, any health problems you have, medications you are taking and any allergies. In particular, make sure you tell them:[2]If you are allergic to any of the ingredients in amantadineAny other medication you are taking, including supplements and herbal remediesIf you have kidney diseaseIf you have or have had a problem with alcohol or other drugsIf you have any other physical or mental illnessIf you are pregnant, trying for a baby or breastfeedingYou should not stop taking amantadine suddenly, as this can cause serious adverse effects, including psychosis, muscle problems, slurred speech, and fever.[2]Amantadine interactionsAmantadine can interact with other medications, drugs and alcohol. Make sure you discuss any medication, supplement, herbal remedies or other substances you are taking with your doctor.Amantadine can seriously interact with the dementia drug memantine, increasing the risk of central nervous system toxicity.[5] It can also interact with other drugs that act on the central nervous system, such as levodopa (prescribed for Parkinson’s disease).[4]Taking amantadine with antipsychotic drugs can increase the risk of psychosis.[4]Some diuretic medications can affect the rate at which amantadine is removed from the body, which can cause adverse reactions.[4]Amantadine storageAmantadine should be stored at room temperature (68-77°F or 20-25°C), away from light and moisture. Always keep medication with the original packaging to check the date and instructions for use. Keep all medication away from children.[6]What to do if you overdose on amantadineIt is possible to overdose on amantadine. The symptoms of an overdose include:[2]Increased heart rateBreathing problemsReduced urinationSwollen limbs, joints, hands or feetStiffness of the limbsInvoluntary movement of parts of the body, including shakingDifficulty with coordinationConfusionDisassociation – feeling disconnected from yourself or your surroundingsFear or angerHallucinationsFeeling lethargicIf you take too much amantadine, contact the Poison Helpline at 1-800-222-1222 or seek emergency medical help immediately.What happens when you stop taking amantadine?Do not stop taking amantadine without medical advice from your doctor. Suddenly stopping amantadine can lead to serious consequences, including psychosis, muscle problems, and fever.[2]References Amantadine: Medication Info Sheets. (n.d.). Children’s Hospital of Eastern Ontario (CHEO). Retrieved November 15, 2022, from Amantadine: Medication Info Sheets Amantadine: MedlinePlus Drug Information. (2021, June 15). MedlinePlus. Retrieved November 15, 2022, from MedlinePlus DailyMed - AMANTADINE capsule. (n.d.). Dailymed.nlm.nih.gov. Retrieved November 25, 2022, from DailyMed Amantadine hydrochloride 100mg capsules - Summary of Product Characteristics (SmPC). (n.d.). Retrieved November 15, 2022, from Electronic Medicines Compendium Amantadine: Interactions. (n.d.). National Institute for Health and Care Excellence. Retrieved November 15, 2022, from Amantadine: Interactions Medical ContentThe Clinical Affairs Team at MentalHealth.com is a dedicated group of medical professionals with diverse and extensive clinical experience. They actively contribute to the development of content, products, and services, and meticulously review all medical material before publication to ensure accuracy and alignment with current research and conversations in mental health. For more information, please visit the Editorial Policy.About MentalHealth.comMentalHealth.com helps people understand themselves, build healthier relationships, and access the right care. We bring together mental health education, diagnostics, and care management to support well-being throughout every phase of life.AuthorAimee AveyardWriterAimee Aveyard is a medical writer with 20+ years of experience in communications.PublishedNovember 23, 2022UpdatedAugust 12, 2025Medical ReviewerLeila Khurshid, Pharm.D.Pharm.D., BCPSLeila Khursid is a medical reviewer with a Doctor of Pharmacy degree and completed a PGY1 Pharmacy Residency from St. Mark's Hospital.ReviewedNovember 25, 2022Subject matter expertLeila Khurshid, Pharm.D.Clinical pharmacy and medicationView experienceRelated communitiesMedicationsExplore questions and perspectives about psychiatric medications and the treatment experience.Explore communityTable of contentsChoose a sectionAmantadine brand namesWhat is amantadine prescribed for?How does amantadine work?How is amantadine usually taken?How long does amantadine stay in your system?Amantadine side effectsAmantadine precautionsAmantadine interactionsAmantadine storageWhat to do if you overdose on amantadineWhat happens when you stop taking amantadine?View moreSubject matter expertLeila Khurshid, Pharm.D.Clinical pharmacy and medicationView experienceRelated communitiesMedicationsExplore questions and perspectives about psychiatric medications and the treatment experience.Explore community","wordCount":1103},"schema":{"@context":"https://schema.org","@graph":[{"@type":"Organization","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/#organization","name":"MentalHealth.com","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/"},{"@type":"WebSite","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/#website","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/","name":"MentalHealth.com","inLanguage":"en-US","publisher":{"@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/#organization"}},{"@type":"BreadcrumbList","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/amantadine#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://mentalhealth-v2.workspace-454808.chatgpt.site/"},{"@type":"ListItem","position":2,"name":"Library","item":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library"},{"@type":"ListItem","position":3,"name":"Medications","item":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/medications"},{"@type":"ListItem","position":4,"name":"Amantadine","item":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/amantadine"}]},{"@type":"ImageObject","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/amantadine#primaryimage","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/optimized/72acaa4c581c77135c102a52.webp","contentUrl":"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/optimized/72acaa4c581c77135c102a52.webp","width":1200,"height":800,"encodingFormat":"image/webp","caption":"A man speaks with a counselor in a comfortable room."},{"@type":"Person","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/aimee-aveyard#person","name":"Aimee Aveyard","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/aimee-aveyard","jobTitle":"Writer","image":"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/optimized/aa73bd6706aa504d661d1292.jpg","sameAs":["https://www.linkedin.com/in/aimee-aveyard/"]},{"@type":"Person","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/leila-khurshid#person","name":"Leila Khurshid, Pharm.D.","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/people/leila-khurshid","jobTitle":"Pharm.D., BCPS","image":"https://mentalhealth-v2.workspace-454808.chatgpt.site/assets/optimized/90339bb61ace127cee8df5f2.webp","sameAs":["https://www.linkedin.com/in/leila-khurshid-pharmd-bcps/"]},{"@type":"Article","@id":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/amantadine#article","url":"https://mentalhealth-v2.workspace-454808.chatgpt.site/library/amantadine","headline":"Amantadine","description":"Amantadine is an antiviral drug for treating Parkinson's disease and other spasmodic conditions. 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